Composite wound dressings of pectin and gelatin with aloe vera and curcumin as bioactive agents

Tummalapalli, Mythili; Berthet, Morgane; Verrier, Bernard; Deopura, B. L.; Alam, Mohammad Sarwar; Gupta, Bhuvanesh

doi:10.1016/j.ijbiomac.2015.10.087

Cited by 143 publications

(85 citation statements)

References 35 publications

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“…39 The presence of this polymeric matrix contributes to the release of the drug from the AV-drug amalgam by leaching process further leading to its diffusion into the wound area, following a biphasic release mechanism. 40 GA acts as a natural binding agent, which possesses antimicrobial activity and nds wide use in therapeutic applications like wound dressing materials. 41 Thus, the biphasic drug release prole of PRWSc observed in this study is due to the presence of AV-GA hydrogel base.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

et al. 2017

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“…Keratin is a natural material with excellent biocompatibility and has been evaluated (Batzer, Marsh, & Kirsner, ; Bhardwaj et al, ; Rouse & Van Dyke, ). Regarding to the common biomaterials for wound healing, there are various dressings or gels used for physical trauma, chronic wound, and other types of injuries, which include hydrocolloids (Grange‐Prunier, Couilliet, Grange, & Guillaume, ; Koo, Piletta‐Zanin, Politta‐Sanchez, Milingou, & Saurat, ), alginates (Balakrishnan, Mohanty, Umashankar, & Jayakrishnan, ; Wang et al, ), hydrogels (Kamoun, Kenawy, & Chen, ; Madaghiele, Demitri, Sannino, & Demitri, ), polyurethane (Gultekin et al, ; Yücedag et al, ), chitosan (Liang et al, ; Ribeiro et al, ; Stricker‐Krongrad et al, ), gelatin (Tanaka, Nagate, & Matsuda, ; Ulubayram, Nur Cakar, Korkusuz, Ertan, & Hasirci, ) pectin (Giusto et al, ; Tummalapalli et al, ), and hyaluronic acid (Neuman, Nanau, Oruna‐Sanchez, & Coto, ; Price, Myers, Leigh, & Navsaria, ). However, these biomaterials have limited application due to poor in vivo persistency.…”

Section: Introductionmentioning

confidence: 99%

Keratin scaffolds with human adipose stem cells: Physical and biological effects toward wound healing

Lin

Chen

Tang

et al. 2019

J Tissue Eng Regen Med

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Keratin, a natural biomaterial derived from wool or human hair, has the intrinsic ability to interact with different types of cells and the potential to serve as a controllable extracellular matrix that can be used a scaffold for tissue engineering. In this study, we demonstrated a simple and fast technique to construct 3D keratin scaffolds for accelerated wound healing using a lyophilization method based on extraction of keratin from human hair. The physical properties of the keratin scaffolds such as water uptake, pore size, and porosity can be adjusted by changing the protein concentrations during the fabrication process. The keratin scaffolds supported human adipose stem cells (hASCs) adhesion, proliferation, and differentiation. In vivo study performed on ICR mice showed that keratin scaffolds with hASCs shortened skin wound healing time, accelerated epithelialization, and promoted wound remodeling. Therefore, keratin scaffolds alone or together with hASCs may serve as therapeutic agents for repairing wounded tissue.

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“…The results suggested that the composite material has an effective antimicrobial nature, and adding aloe vera promotes would healing and infection control. Tummalapalli et al [141] loaded aloe vera and curcumin into oxidized pectin-gelatin matrices to fabricate a composite wound dressing. The composite wound dressing was found to exhibit very rapid wound healing, and aloe vera showed a strong anti-inflammatory effect and prominent scar prevention.…”

Section: Aloe Vera Based Gels and Filmsmentioning

confidence: 99%

Aloe Vera for Tissue Engineering Applications

Rahman

Carter

Bhattarai

2017

JFB

154

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Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components. The bioactive components of aloe vera have effective antibacterial, anti-inflammatory, antioxidant, and immune-modulatory effects that promote both tissue regeneration and growth. The aloe vera plant, its bioactive components, extraction and processing, and tissue engineering prospects are reviewed in this article. The use of aloe vera as tissue engineering scaffolds, gels, and films is discussed, with a special focus on electrospun nanofibers.

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Composite wound dressings of pectin and gelatin with aloe vera and curcumin as bioactive agents

Cited by 143 publications

References 35 publications

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

Keratin scaffolds with human adipose stem cells: Physical and biological effects toward wound healing

Aloe Vera for Tissue Engineering Applications

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