Composite vascular repair grafts via micro-imprinting and electrospinning

Liu, Yuanyuan; Ke, Xiang; Chen, Haiping; Liu, Yu; Hu, Qingxi

doi:10.1063/1.4906571

Cited by 13 publications

(10 citation statements)

References 11 publications

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“…However, limited by the respective defects in polymer and natural materials, most groups have adopted the hybrid strategy to prepare scaffold-based vessels using a combination of different materials. For example, Ju et al prepared bi-layered scaffolds based on poly(caprolactone) (PCL) and collagen,17 and Liu et al explored the possible application of a tri-layered scaffolds with an inner and outer layer based on poly(vinyl alcohol) (PVA)/chitosan and a middle layer based on poly(p-dioxanone) (PPDO) 18. In addition, to achieve accomplished functional vascular remodeling after transplantation, especially endothelialization and ready proliferation of the vascular smooth muscle cells (the best anti-thrombotic drug in the body), cell inoculation or bio-active factors loading in vitro had been employed.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a simple off-the-shelf bi-layered vascular scaffold based on poly(L-lactide-co-ε-caprolactone)/silk fibroin in vitro and in vivo

Jin¹,

Hu²,

Xia³

et al. 2019

IJN

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Purpose: In the field of small-caliber vascular scaffold research, excellent vascular remodeling is the key to ensuring anticoagulant function. We prepared an off-the-shelf bi-layered vascular scaffold with a dense inner layer and a loose outer layer and evaluated its remodeling capabilities by in vivo transplantation. Materials and Methods: Based on poly(L-lactide-co-ε-caprolactone) (PLCL), silk fibroin(SF), and heparin (Hep), PLCL/SF/Hep bi-layered scaffolds and PLCL/Hep bi-layered scaffolds were prepared by electrospinning. The inner layer was a PLCL/SF/Hep or PLCL/Hep nanofiber membrane, and the outer layer was PLCL/SF nano yarn. The in vitro tests included a hydrophilicity test, mechanical properties test, and blood and cell compatibility evaluation. The in vivo evaluation was conducted via single rabbit carotid artery replacement and subsequent examinations, including ultrasound imaging, immunoglobulin assays, and tissue section staining. Results: Compared to the PLCL/Hep nanofiber membrane, the hydrophilicity of the PLCL/SF/Hep nanofiber membrane was significantly improved. The mechanical strength met application requirements. Both the blood and cell compatibility were optimal. Most importantly, the PLCL/SF/Hep scaffolds maintained lumen patency for 3 months after carotid artery transplantation in live rabbits. At the same time, CD31 and α-SMA immunofluorescence staining confirmed bionic endothelial and smooth muscle layers remodeling. Conclusion: Using this hybrid strategy, PLCL and SF were combined to manufacture bi-layered small-caliber vascular scaffolds; these PLCL/SF/Hep scaffolds showed satisfactory vascular remodeling.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a simple off-the-shelf bi-layered vascular scaffold based on poly(L-lactide-co-ε-caprolactone)/silk fibroin in vitro and in vivo

Jin¹,

Hu²,

Xia³

et al. 2019

IJN

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“…Among various attempts, the most representative one lies in the preparation of the artificial blood vessel, which contains the integration of micro-nano fibers generated by electrospinning and the macrostructure formed by extrusion printing to mimic the multilayer structure of the blood vessel wall and regulate the mechanical properties[ 32 - 36 ]. Wu et al .…”

Section: The Process Of 3d Composite Bioprintingmentioning

confidence: 99%

3D Composite Bioprinting for Fabrication of Artificial Biological Tissues

Zhang¹,

Wang²,

Jun-chao³

et al. 2024

IJB

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Three-dimensional (3D) bioprinting is an important technology for fabricating artificial tissue. To effectively reconstruct the multiscale structure and multi-material gradient of natural tissues and organs, 3D bioprinting has been increasingly developed into multi-process composite mode. The current 3D composite bioprinting is a combination of two or more printing processes, and oftentimes, physical field regulation that can regulate filaments or cells during or after printing may be involved. Correspondingly, both path planning strategy and process control all become more complex. Hence, thecomputer-aided design and computer-aided manufacturing (CAD/CAM) system that is traditionally used in 3D printing systemis now facing challenges. Thus, the scale information that cannot be modeled in the CAD process should be considered inthe design of CAM by adding a process management module in the traditional CAD/CAM system and add more informationreflecting component gradient in the path planning strategy.

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“…Physical, chemical, and mechanical characters of chitosan fibers and the ability to build in different forms facilitate chitosan nanofibers for the filtration process, for example, metal and dyes separation from water [20,21], capturing of virus in air [22], etc. In addition, the technological developments in textile processing associated with chitin and chitosan would impact on reinforcing microfibers composite [23], dressing for wound skin [15,[24][25][26], carrying and delivering drugs [22,27], tissue engineering [15,[28][29][30], vascular grafts [31], etc.…”

Section: Mechanical Properties Of Fibersmentioning

confidence: 99%

Chitosan-Based Sustainable Textile Technology: Process, Mechanism, Innovation, and Safety

Roy¹,

Salaün²,

Giraud³

et al. 2017

Biological Activities and Application of Marine Polysaccharides

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This chapter reviews relevant findings regarding the activities and contributions of chitosan in different textile processing following the varieties of process, mechanism, and applications. Chitosan is a better candidate in both aspects of biodegradability and efficiency instead of synthetic polymers. The technical and scientific discussions behind the role of chitosan in all the processes and treatments have been explored in the chapter. Over the last few years, enormous efforts and challenges are being practiced in research and industry to design and development of eco-friendly and sustainable technologies. Therefore, the chapter emphasizes on chitosan-based formulations of fibers, fabrics, coatings, and functional textiles.

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Composite vascular repair grafts via micro-imprinting and electrospinning

Cited by 13 publications

References 11 publications

<p>Evaluation of a simple off-the-shelf bi-layered vascular scaffold based on poly(L-lactide-co-ε-caprolactone)/silk fibroin in vitro and in vivo</p>

<p>Evaluation of a simple off-the-shelf bi-layered vascular scaffold based on poly(L-lactide-co-ε-caprolactone)/silk fibroin in vitro and in vivo</p>

3D Composite Bioprinting for Fabrication of Artificial Biological Tissues

Chitosan-Based Sustainable Textile Technology: Process, Mechanism, Innovation, and Safety

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