Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases

Abstract

This is the largest case serial of composite SLL/CLL and FL. The CL affects elderly individuals, presents with advanced clinical stage, and appears to have a relatively indolent clinical course.

Biclonal cluster lymphoma: SLL/CLL and FL diagnosed on fine needle aspirate flow cytometry—Report of an interesting case

“…Most of the cases, where FISH analysis was available showed presence of BCL2 rearrangement in the form of IgH/BCL2 fusion. Our case was negative for IgH/BCL2 fusion as well as trisomy 12, similar to the two other cases reviewed by Jelloul et al (2018) (Supporting Information, Table S1).…”

“…Our case did not have any history of prior malignancy. Jelloul et al (2018) reported six cases of SLL and FL CL and additionally reviewed 13 other cases reported in literature. The median age was 70 years with a male predominance.…”

The broad landscape of follicular lymphoma: Part II

“…CL with FL and CLL/SLL is extremely rare ( Fig. 16 ) 65 . An interesting study of Boiocchi et al supported the notion that composite low-grade B-cell lymphomas are usually biclonal 66 .…”

“…An interesting study of Boiocchi et al supported the notion that composite low-grade B-cell lymphomas are usually biclonal 66 . Another recent study, reporting the largest case series of composite CLL/SLL and FL did not perform microdissection, so that the relationship between the two components cannot be definitively determined 65 .…”

Primary Cutaneous Composite Lymphomas

“…7,10,[12][13][14][15][16][17][18][19][20][21][22][23][24] Cutaneous CLs, although rare, include secondary involvement of the skin by systemic/nodal lymphomas, 7,11,14,25,26 or a mixture of primary and secondary cutaneous lymphomas. 14,21,[27][28][29][30][31][32] More recently, primary cutaneous CLs in which both lymphoma components are primary cutaneous lymphomas have been described (reviewed in the Table; see Figures 1 and 2). [19][20][21][22]24,33 Although only a handful of these cases have been described, the reported cases are CLs composed of Bcell/T-cell lymphomas.…”