Composite phospholipid-gold nanoparticles with targeted fragment for tumor imaging

Sanzhakov, M. A.; Kudinov, V.A.; Baskaev, K. K.; Morozevich, G. E.; Stepanova, Dina; Torkhovskaya, T. I.; Tereshkina, Yu.A.; Korotkevich, Ekaterina; Tikhonova, E G

doi:10.1016/j.biopha.2021.111985

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…The employment of gold in biomedical imaging is attributed to its ability to exhibit unique optical imaging properties and being excellent contrast for TEM-based and X-ray based imaging. For instance, Sanzhakov et al have developed a AuNP-liposome nanocomposites for tumor imaging [33]. The accumulation of AuNP-liposome nanocomposite was tracked in mice using computed tomography (CT) scanner to evaluate the contribution of targeting moiety on the uptake into tumor in vivo and to confirm that PEGylation of AuNP-Phospholipid nanocomposite improves the accumulation of AuNP in the tumor site (Figure 8).…”

Section: Imagingmentioning

confidence: 99%

“…Usually, these nanocomposites hold innovative physicochemical properties to offer new types of applications [8]. In the recent years, several AuNP-based nanocomposites have been prepared including AuNP-carbon nanotubes nanocomposites [25,26], AuNP-polymer nanocomposites [27,28], AuNP-graphene nanocomposites [29], AuNP-metal oxide nanocomposites [30], AuNP-protein nanocomposites [31,32] and AuNPliposome nanocomposites [33,34]. In previous contributions, we described the facile preparation of AuNP-polymeric nanocomposites and the complete encapsulation of AuNP into PLGA nanocarriers [35,36].…”

Section: Introductionmentioning

confidence: 99%

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The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Idoudi

Ismail

Rachid

et al. 2023

JNT

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Gold nanoparticles (AuNP) have received a growing attention due to their fascinating physiochemical properties and promising range of biomedical applications including sensing, diagnosis and cancer photothermal ablation. AuNP enjoy brilliant optical properties and ability to convert light into local heat and function as a “nanoheaters” to fight cancer. However, AuNP are poor drug delivery systems as they do not have reservoirs or matrices to achieve an acceptable drug loading efficiency. On the other end, liposome-based nanocarriers do not exhibit such optical properties but are excellent platform for drug loading and they have been proven clinically with a true presence in the market since the FDA approved Doxil® in 1995. Combining the brilliant optical and photothermal properties of AuNP with the excellent drug loading capability of liposome should yield nanocomposites that enjoy the features of both modalities and enable the development of novel and smart drug delivery systems. Therefore, this review discusses the up-to date research on the AuNP-liposome nanocomposites and the current available approaches and protocols for their preparation and characterization. Finally, the biomedical applications of AuNP-liposome nanocomposites and proposed future directions in this field are discussed.

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Section: Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Idoudi

Ismail

Rachid

et al. 2023

JNT

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“…Some nanohybrids showed excellent therapeutic performance despite using unimodal approaches (e.g., single PTT). The potential of GNP nanohybrids as imaging agents was also evident [ 106 , 122 , 179 , 183 , 185 ], thereby providing an advantage for their future utilization for image-guided therapy. It is particularly interesting for a single nanocomposite to simultaneously hold several therapeutic features.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

et al. 2022

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With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including liposomes and polymers, to achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. The GNP nanohybrids used for targeted chemotherapy can be designed to respond to external stimuli such as heat or internal stimuli such as intratumoral pH. Despite their promise for multimodal cancer therapy, there are currently no reviews summarizing the current status of GNP nanohybrid use for cancer theragnostics. Therefore, this review fulfills this gap in the literature by providing a critical analysis of the data available on the use of GNP nanohybrids for cancer treatment with a specific focus on synergistic approaches (i.e., triggered drug release, photothermal therapy, and radiotherapy). It also highlights some of the challenges that hinder the clinical translation of GNP hybrid nanostructures from bench to bedside. Future studies that could expedite the clinical progress of GNPs, as well as the future possibility of improving GNP nanohybrids for cancer theragnostics, are also summarized.

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Engineered Hybrid Nanoparticles for Multimodal Medical Imaging and Diagnosis

Shetty

Chandra

2022

Nanomaterials for Cancer Detection Using Imaging Techniques and Their Clinical Applications

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Composite phospholipid-gold nanoparticles with targeted fragment for tumor imaging

Cited by 4 publications

References 26 publications

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

Engineered Hybrid Nanoparticles for Multimodal Medical Imaging and Diagnosis

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