Composite nanoparticles: A new way to siliceous materials and a model of biosilica synthesis

Annenkov, Vadim V.; Pal’shin, Viktor A.; Verkhozina, O. N.; Ларина, Л. И.; Danilovtseva, Elena N.

doi:10.1016/j.matchemphys.2015.09.022

Cited by 19 publications

(15 citation statements)

References 48 publications

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“…Interaction between growing PSA nanoparticles and macromolecular chains oen results in stable soluble nanoparticles 63,64,85,[90][91][92][93]95,96,115,116,120,131,132 or in a product consisting of uniform spherical composite particles. 24,61,62,[65][66][67][68][69][70][71][75][76][77]98,99,[106][107][108]111,112,114,117,121,124,134,135,137,139,143,149,153,155,157 These variants exist in the case of relatively low silicon content in the system, when all PSA nanoparticles can nd chains of organic polymer.…”

Section: Polymer : Si Ratiomentioning

confidence: 99%

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Silicic acid condensation under the influence of water-soluble polymers: from biology to new materials

et al. 2017

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Silicon is among the most abundant elements on the Earth. It occurs in many minerals and plays an important role in several biochemical processes. Some living organisms use silicon dioxide as a substrate for building elements of their bodies. Unicellular diatom algae build frustules from silicon dioxide. The skeleton of siliceous sponges is a silicaprotein composite. Similarly, rice hulls which protect seeds, contain silica as an important component. The living organisms assimilate silicon from the environment in the form of silicic acid. However, the biochemical mechanisms involved in the transformation of silicic acid to solid siliceous materials are still poorly understood.Evidently, condensation of silicic acid in the living organisms proceeds under control of biopolymers and it is important to know how various types of polymers influence the condensation. Bio-inspired chemistry involving the interaction between polymeric silicic acid and functional polymers results in interesting composite materials, including nanoparticles and bulk materials. This review contains a brief description of the mechanism of silicic acid condensation in aqueous medium and also includes a discussion on various precursors of silicic acid. The main focus of the review is on the influence of polymers bearing nitrogen and oxygen-containing functional groups on silicic acid condensation starting from monomer to three-dimensional polymer. Influence of molecular weight of the organic polymer on the condensation and structure of the resulting product is also elaborated. The biological importance of the obtained data and strategies for novel applications of the synthesized composite materials are described in the concluding section of the review. The biomimetic condensation processes open up new vistas for development of novel materials and applications in the biomedical and process industries.

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Section: Polymer : Si Ratiomentioning

confidence: 99%

“…We have done a model experiment with polyampholyte containing polyamine sidechains. 96 Desiccation was simulated by centrifugation at 50 000g which concentrated the composite organo-silica particles at the bottom of the centrifuge tube. We found formation of precipitate from 100-200 nm sintered particles.…”

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Silicic acid condensation under the influence of water-soluble polymers: from biology to new materials

et al. 2017

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“…Another hypothesis considers LCPAs as compounds that stabilize cytoplasmic silicon in the form of oligosilicates. According to this hypothesis, oligosilicates are the particles to be responsible for cytoplasmic storage and the transport of silicon ,. Condensation of the oligosilicates gives rise to the elements of siliceous frustules, and the stabilizing LCPAs are removed, which explains their low content in the diatom frustules (nitrogen content <0.05%).The high diversity of LCPAs, which is not directly connected to the peculiarities of the diatoms, possibly points to a minor importance of LCPAs structure in the biochemical synthesis of silica frustules of a definite morphology.…”

Section: Resultsmentioning

confidence: 99%

Unusual Polyamines from Baikalian Diatoms

et al. 2018

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Siliceous frustules of diatom algae contain a low amount of organic substances which are buried in the silicon dioxide and remain intact after a thousands years in marine and lake sediments. These substances are studied as potential silicification agents which are responsible for formation of the biosilica. On the other hand, the organic compounds from sediments are a prospective source of carbon and nitrogen for isotopic paleoreconstructions. The main part of these compounds from marine diatoms consists of polyamines which contain trimethylene insertions between nitrogen atoms. The study of polyamines from siliceous frustules of Baikalian diatom Stephanodiscus meyeri Genkal & Popovskaya revealed the presence of a new type of polyamine that contains tetramethylene insertions between nitrogen atoms in the repeating units. The other freshwater diatom Ulnaria ferefusiformis Kulikovskiy & Lange‐Bertalot contained polyamines with trimethylene insertions similar to those in the previously‐studied marine diatoms and the Baikal sediments contained polyamines of both types. These results are important to understanding the role of polyamines in silica biosynthesis. The species specificity of the polyamine structure can be applied as a new paleo marker.

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“…Grafting of the LCPA chains on to poly(acrylic acid) resulted in polyampholytes which can control condensation of silicic acid giving rise to silica, the structure of which was similar to biogenic silica [25]. Neutral polymers with pendant LCPAs can interact with SNA and the obtained complexes are promising particles for gene therapy [14].…”

Section: Introductionmentioning

confidence: 99%

Design of the Oligonucleotide Carriers: Importance of Polyamine Chain Length

Annenkov¹,

Krishnan²,

Pal’shin³

et al. 2018

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Amine containing polymers are extensively studied as special carriers for short-chain RNA (13–25 nucleotides) which are applied as gene silencing agent in gene therapy of various diseases including cancer. Elaboration of the oligonucleotide carriers requires knowledge about peculiarities of oligonucleotide - polymeric amine interaction. Critical length of the interacting chains is the important parameter which allows to design sophisticated constructions containing oligonucleotide binding segments, solubilizing, protective and aiming parts. We studied interaction of (TCAG)n, n=1-6 DNA oligonucleotides with polyethylenimine and poly(N-(3-((3-(dimethylamino)propyl)(methyl)amino)propyl)-N-methylacrylamide). Critical length for oligonucleotides in interaction with polymeric amines is 8-12 units and complexation at these length can be accompanied by "all-or-nothing" effects. New dimethylacrylamide based polymers with grafted polyamine chains were obtained and studied in complexation with DNA and RNA oligonucleotides. The most effective interaction and transfection activity into A549 cancer cells was found for a sample with average number of nitrogens in polyamine chain equal to 27, i.e. for a sample in which all grafted chains are longer the critical length for polymeric amine - oligonucleotide complexation.

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Composite nanoparticles: A new way to siliceous materials and a model of biosilica synthesis

Cited by 19 publications

References 48 publications

Silicic acid condensation under the influence of water-soluble polymers: from biology to new materials

Silicic acid condensation under the influence of water-soluble polymers: from biology to new materials

Unusual Polyamines from Baikalian Diatoms

Design of the Oligonucleotide Carriers: Importance of Polyamine Chain Length

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