Composite mycosis fungoides and B-cell chronic lymphocytic leukemia

Volk, Andrea L.; Vannucci, Stephen A.; Cook, William A.; Thompson, Kenneth; Listinsky, Catherine M.

doi:10.1053/adpa.2002.33904

Cited by 37 publications

(49 citation statements)

References 22 publications

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“…The simultaneous occurrence of SS and CLL in the same patient is rare, but 5 other cases with erythroderma and the presence of neoplastic T cells in the blood in addition to our case have been reported in the literature [13,14,15,16]. In 2002, Volk et al[ 13] reported a case that demonstrated the temporal development of SS in a patient with CLL.…”

Section: Discussionmentioning

confidence: 53%

“…Of the 47 cases reported to that time, 18 (38%) had CLL, and we have summarized the clinical features of these cases plus 8 additional cases in table 1[13,14,15,16,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. It should be noted that 3 cases from the literature had skin lesions that were clinically atypical for CTCL.…”

Section: Discussionmentioning

confidence: 99%

“…In 2002, Volk et al[ 13] reported a case that demonstrated the temporal development of SS in a patient with CLL. Generalized erythroderma first appeared 5 years after the diagnosis of CLL and initial skin biopsy specimens showed a perivascular and periadnexal infiltrate containing clonal B-cells as shown by immunohistochemistry and by Southern blot analysis of the IgH gene.…”

Section: Discussionmentioning

confidence: 99%

“…The patient with SS described by Volk et al[ 13] also presented with erythroderma and a high CD4/CD8 ratio before T-cell gene rearrangement studies demonstrated a T-cell clone. Other studies on our patient (absolute Sézary cell count of 3,093/mm 3 ; chromosome karyotyping and fluorescence in situ hybridization on sorted cells; molecular genetic evidence of a T-cell clone in the blood) were needed to confirm the diagnosis of SS.…”

Section: Discussionmentioning

confidence: 99%

“…Herein, we present a case of SS that developed in a patient with CLL, an association that to our knowledge has been reported five times before [13,14,15,16]. Because the neoplastic T cells of our patient reacted with an antibody that recognized the variable region of the β-chain (Vβ) of the TCR, we were able to monitor the differential effects of various treatments on the CLL and SS and to characterize a change in the immunophenotype of the neoplastic T cells from CD4+CD7+CD25– to CD4+CD7–CD25+, which we believe is the result of clonal selection.…”

Section: Introductionmentioning

confidence: 92%

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Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2007

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Introduction: The simultaneous presentation of chronic B-cell lymphocytic leukemia (B-CLL) and cutaneous T-cell lymphoma (CTCL) is extremely rare. Case Report: We describe a patient with B-CLL and Sézary syndrome (SS), an erythrodermic and leukemic variant of CTCL. Despite treatment, the SS progressed to involve internal organs and eventual death of the patient from sepsis. This is the first reported case of SS coexisting with chronic lymphocytic leukemia in which an anti-Vβ13.6 antibody was used to serially track changes in circulating neoplastic T cells vis-à-vis neoplastic B cells and to detect neoplastic T cells in ascitic fluid near the end of the patient’s life. Discussion: We speculate that the coexistence of B-CLL and CTCL is the result of an initiating genetic or epigenetic defect at the level of the common lymphoid stem cell that predisposes both B-cell and T-cell lineages to additional oncogenic changes at a more advanced stage of differentiation.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

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Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2007

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Folliculotropic Mycosis Fungoides

et al. 2010

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To clarify clinicopathologic features and reconcile discrepancies in previous studies of folliculotropic mycosis fungoides (FMF).Design: A single-center retrospective clinicopathologic study and a systematic review of FMF.Setting: Tertiary referral center in the midwestern United States.Patients: Patients with clinical and histopathologic evidence of FMF seen at the tertiary referral center during a 12 1 ⁄2-year period.Main Outcome Measures: Clinicopathologic features of FMF.Results: Fifty patients (32 male [64%] and 18 female [36%]) met study criteria for the clinicopathologic review. Pruritic patches, plaques, and folliculocentric lesions (milia, cysts, and alopecia) on the head, neck, and

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Chronic Lymphocytic Leukemia of B Cell and T Cell Prolymphocytic Leukemia

2016

The Cutaneous Lymphoid Proliferations

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Composite mycosis fungoides and B-cell chronic lymphocytic leukemia

Cited by 37 publications

References 22 publications

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

Folliculotropic Mycosis Fungoides

Chronic Lymphocytic Leukemia of B Cell and T Cell Prolymphocytic Leukemia

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