Composite materials with embedded metal organic framework catalysts for nitric oxide release from bioavailable S-nitrosothiols

Harding, Jacqueline L.; Reynolds, Melissa M.

doi:10.1039/c3tb21458c

Cited by 37 publications

(35 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…210–212 It has been reported that CuBTC can be extruded within Tecoflex SG80A polyurethane into single lumen tubing while maintaining the catalyst structure and functionality. The in vitro NO release generated from endogenous RSNO species ranges from 1 h to 16 h with tunable dosage, depending on the specific RSNO levels present in the soaking solution.…”

Section: Polymer-based Strategies For No Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

View full text Add to dashboard Cite

Biomedical devices are essential for patient diagnosis and treatment; however, when blood comes in contact with foreign surfaces or homeostasis is disrupted, complications including thrombus formation and bacterial infections can interrupt device functionality, causing false readings and/or shorten device lifetime. Here, we review some of the current approaches for developing antithrombotic and antibacterial materials for biomedical applications. Special emphasis is given to materials that release or generate low levels of nitric oxide (NO). Nitric oxide is an endogenous gas molecule that can inhibit platelet activation as well as bacterial proliferation and adhesion. Various NO delivery vehicles have been developed to improve NO’s therapeutic potential. In this review, we provide a summary of the NO releasing and NO generating polymeric materials developed to date, with a focus on the chemistry of different NO donors, the polymer preparation processes, and in vitro and in vivo applications of the two most promising types of NO donors studied thus far, N-diazeniumdiolates (NONOates) and S-nitrosothiols (RSNOs).

show abstract

Section: Polymer-based Strategies For No Deliverymentioning

confidence: 99%

“…The in vitro NO release generated from endogenous RSNO species ranges from 1 h to 16 h with tunable dosage, depending on the specific RSNO levels present in the soaking solution. 210 …”

Section: Polymer-based Strategies For No Deliverymentioning

confidence: 99%

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

View full text Add to dashboard Cite

show abstract

“…While the enhanced biological effects of NO releasing materials have been studied with metal ions like iron and copper, [25][26][27] and polyurethane/metal-organic framework composite materials, 28 the catalytic effects of a much more mammalian cell friendly metal ion, ZnO-NPs, has not been studied until now. In the past, the ability of Zn 2+ to generate to generate NO from SNAP has been studied using a Zn wire and a solution for in vivo biodegradable bare stent and has been found to elevate NO release.…”

Section: Introductionmentioning

confidence: 99%

Zinc‐oxide nanoparticles act catalytically and synergistically with nitric oxide donors to enhance antimicrobial efficacy

Singha

Workman

Pant

et al. 2019

J Biomedical Materials Res

View full text Add to dashboard Cite

The development of infection‐resistant materials is of substantial importance as seen with an increase in antibiotic resistance. In this project, the nitric oxide (NO)‐releasing polymer has an added topcoat of zinc oxide nanoparticle (ZnO‐NP) to improve NO‐release and match the endogenous NO flux (0.5–4 × 10−10 mol cm−2 min−1). The ZnO‐NP is incorporated to act as a catalyst and provide the additional benefit of acting synergistically with NO as an antimicrobial agent. The ZnO‐NP topcoat is applied on a polycarbonate‐based polyurethane (CarboSil) that contains blended NO donor, S‐nitroso‐N‐acetylpenicillamine (SNAP). This sample, SNAP‐ZnO, continuously sustained NO release above 0.5 × 10−10 mol cm−2 min−1 for 14 days while samples containing only SNAP dropped below physiological levels within 24 h. The ZnO‐NP topcoat improved NO release and reduced the amount of SNAP leached by 55% over a 7‐day period. ICP‐MS data observed negligible Zn ion release into the environment, suggesting longevity of the catalyst within the material. Compared to samples with no NO‐release, the SNAP‐ZnO films had a 99.03% killing efficacy against Staphylococcus aureus and 87.62% killing efficacy against Pseudomonas aeruginosa. A cell cytotoxicity study using mouse fibroblast 3T3 cells also noted no significant difference in viability between the controls and the SNAP‐ZnO material, indicating no toxicity toward mammalian cells. The studies indicate that the synergy of combining a metal ion catalyst with a NO‐releasing polymer significantly improved NO‐release kinetics and antimicrobial activity for device coating applications. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 00A: 000–000, 2019.

show abstract

“…HKUST-1 was found to catalytically decompose RSNOs to generate NO. [17] These results inspired us to deposit HKUST-1 for surface modification of biomaterials to obtain simultaneously anticoagulant and antibacterial coating.…”

Section: Doi: 101002/admi201902011mentioning

confidence: 99%

Substrate Independent Liquid Phase Epitaxy of HKUST‐1 as Anticoagulant and Antimicrobial Coating

Zhao

Liu

et al. 2020

Adv Materials Inter

View full text Add to dashboard Cite

The effective deposition of metal–organic frameworks on kinds of biomaterials is still challenging and highly desirable. Using polydopamine as the effective nucleation center, HKUST‐1 is successfully prepared on three kinds of inert biomaterials, i.e., titanium oxide film (Ti–O), 316L stainless steel (316L SS), and poly(vinyl chloride) (PVC). Characterization of the surfaces by powder X‐ray diffraction confirm the oriented crystal growth of HKUST‐1 on the polydopamine coated substrates. There are no significant difference in catalytical NO generation and surface copper content of the three samples with HKUST‐1 deposition. All keep a NO release speed of ≈2.5 × 10−10 mol cm−2 min−1, thus platelet activation on the HKUST‐1 modified surfaces are inhibited compared to that of the unmodified ones. Ex vivo test shows thrombi formation is dramatically reduced. The HKUST‐1 coated surfaces elicit 95% reduction in the bacterial attachment of both Staphylococcus aureus and Escherichia coli. The endothelial cells and macrophages culture results support good biocompatibility of the modified surfaces. It provides a promising, facile, and effective approach for surface modification of blood contact biomaterials.

show abstract

Composite materials with embedded metal organic framework catalysts for nitric oxide release from bioavailable S-nitrosothiols

Cited by 37 publications

References 49 publications

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Zinc‐oxide nanoparticles act catalytically and synergistically with nitric oxide donors to enhance antimicrobial efficacy

Substrate Independent Liquid Phase Epitaxy of HKUST‐1 as Anticoagulant and Antimicrobial Coating

Contact Info

Product

Resources

About