Composite lymphoma. Report of a unique case

Poon, Man‐Chiu; Flint, Andrew; Miles, Gordon

doi:10.1002/1097-0142(19801001)46:7<1676::aid-cncr2820460729>3.0.co;2-5

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…Initially based on the presence of two morphologically distinct components in the same anatomical site, refined criteria required the demonstration of distinct immunophenotypes, and ultimately, molecular evidence of distinct clonal origins of the two tumor cell populations. 13,15,18,24,25,36 The most frequent occurrence of two different lymphoma morphologies presenting in the same patient is a high grade tumor arising in the setting of a concomitant or antecedent low grade neoplasm. This generally represents histological transformation of the low grade tumor, and a common clonal origin can be demonstrated in most, but not all, cases.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,14,16,20,21,23,37 Composite B-cell neoplasms with two phenotypically different low grade components are infrequent; only a few reports contain sufficient immunophenotypic and molecular genetic information. 9,11,13,[17][18][19]25,36 Although our three cases showed some unusual morphological features, only a detailed immunophenotypic analysis made a diagnosis of composite lymphoma possible. The differential expression of markers such as CD5, CD10, CD43, and cyclin D1 allowed us to identify the two cytological and architectural patterns as distinct tumor components and also to distinguish the FL infiltrates of Case 1 and the MCL nodules of Case 3 from residual germinal centers.…”

Section: Discussionmentioning

confidence: 99%

“…Among the biphenotypic neoplasms, composite non-Hodgkin's lymphomas, ie, tumors with two morphologically and/or phenotypically different components in the same anatomical site, are rare, and some earlier reports lack molecular studies. 13,15,[17][18][19]24,25 We present three cases of low grade B-NHL with two morphologically and immunophenotypically distinct tumor components occupying different but intimately interwoven microenvironments in the involved tissue. Molecular analysis of the two tumor components obtained by laser capture microdissection (LCM) revealed two unrelated clonal populations in all three cases despite their synchronous anatomical presentation.…”

Section: :1857-1866)mentioning

confidence: 99%

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Composite Low Grade B-Cell Lymphomas with Two Immunophenotypically Distinct Cell Populations Are True Biclonal Lymphomas

Fend

Quintanilla-Martı́nez

Kumar

et al. 1999

The American Journal of Pathology

150

115

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Low grade B-cell lymphomas comprise several well defined, clinically and immunophenotypically distinct disease entities. Composite lymphomas showing phenotypic characteristics of more than one of these tumor subtypes in the same site are rare, and both common and separate clonal origins of the two tumor parts have been reported for cases studied by molecular methods. We describe the detailed immunohistochemical and molecular findings in three cases with features of composite low grade B-cell non-Hodgkin's lymphoma (B-NHL). All three neoplasms contained morphologically distinct but interwoven compartments of different cell types, which exhibited discordant expression of several markers, including CD5, CD10, CD43, and cyclin D1. According to their morphology and phenotypes, they were classified as mantle cell lymphoma and follicular lymphoma (Case 1), follicular lymphoma and small lymphocytic lymphoma (Case 2), and mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (Case 3). PCR analysis of DNA obtained from whole tissue sections failed to reveal evidence for biclonality in any of the cases. We therefore isolated cell populations with different antigen expression patterns by laser capture microdissection and analyzed them by polymerase chain reaction amplification and sequencing of clonal immunoglobulin heavy chain gene rearrangements and oncogene rearrangements. Sequence analysis revealed unrelated clonal rearrangements in each of the two tumor parts in all three cases, suggesting distinct clonal origins. In addition, Case 1 showed a bcl-2 rearrangement present only in the follicular lymphoma part. Our findings suggest that low grade B-NHL with two distinct morphological and immunophenotypic patterns in the same anatomical site are frequently biclonal. This is in keeping with current classification schemes, which recognize subtypes of low grade B-NHL as separate disease entities. Furthermore, our analysis demonstrates the power of laser capture microdissection in revealing molecular microheterogeneity in complex neoplasms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: :1857-1866)mentioning

confidence: 99%

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Composite Low Grade B-Cell Lymphomas with Two Immunophenotypically Distinct Cell Populations Are True Biclonal Lymphomas

Fend

Quintanilla-Martı́nez

Kumar

et al. 1999

The American Journal of Pathology

150

115

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Primary gastric lymphomas: A clinicopathologic study of 58 cases with long-term follow-up and literature review

Brooks

Enterline

1983

Cancer

204

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A large series of primary gastric lymphomas with long‐term follow‐up (average, 12.8 years) is reported. A number of factors known to affect nodal lymphoma were examined. Five‐and ten‐year survival rates were 57 and 46%, respectively. Statistically significant favorable prognostic variables were smaller tumor size (≤7 cm), superficial mural invasion (submucosal only), and pathologic Stage I disease; these variables were intimately interrelated. A favorable influence on survival was discerned concerning histologic type and nodular histology, although still below statistical significance. No significant relation to survival was observed concerning clinical weight loss or palpable mass, vascular invasion, mode of therapy, or histologic subtypes of “histocytic” lymphoma. Of patients who succumbed to disease, 75% did so within two years (average, 1.8 years); however, later recurrence and death may occur. An argument for resection of localized disease is presented. Mitotic index and nuclear diameter were of diagnostic importance, and associated lesions such as pseudolymphomas are discussed in relation to pathogenesis. Histologic variation within tumors suggested visualization of clonal development in non‐Hodgkin's lymphomas.

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Discordant Malignant Lymphoma Synchronous or Successive High-grade B Lymphoma Associated with Hodgkin#X2019:s Disease

Damotte¹,

Tourneau²,

Audouin³

et al. 1995

Pathology - Research and Practice

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Composite lymphoma. Report of a unique case

Cited by 3 publications

References 25 publications

Composite Low Grade B-Cell Lymphomas with Two Immunophenotypically Distinct Cell Populations Are True Biclonal Lymphomas

Composite Low Grade B-Cell Lymphomas with Two Immunophenotypically Distinct Cell Populations Are True Biclonal Lymphomas

Primary gastric lymphomas: A clinicopathologic study of 58 cases with long-term follow-up and literature review

Discordant Malignant Lymphoma Synchronous or Successive High-grade B Lymphoma Associated with Hodgkin#X2019:s Disease

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