Discordant Malignant Lymphoma Synchronous or Successive High-grade B Lymphoma Associated with Hodgkin#X2019:s Disease

Damotte, Diane; Tourneau, A. Le; Audouin, Josée; Duval, Christian; Martin-Bastenaire, F.; Villain, O.; Delobelle-Deroide, A; Diébold, J

doi:10.1016/s0344-0338(11)80916-7

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…6,7 There is a paucity of published experience on the biology, diagnosis, treatment, and outcome of discordant lymphomas, and data are mostly derived from single case reports and small retrospective studies. [8][9][10][11][12][13][14][15][16][17] Consequently, the incidence, clinical behavior, and optimal therapeutic approach to discordant lymphomas remain controversial with little overall consensus. In this review, we analyze the published literature on discordant non-Hodgkin lymphomas (NHLs), with particular emphasis on DLBCL.…”

Section: Introductionmentioning

confidence: 99%

Discordant bone marrow involvement in non-Hodgkin lymphoma

Brudno

Tadmor

Pittaluga

et al. 2016

Blood

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A discordant lymphoma occurs where 2 distinct histologic subtypes coexist in at least 2 separate anatomic sites. Histologic discordance is most commonly observed between the bone marrow (BM) and lymph nodes (LNs), where typically aggressive lymphoma is found in a LN biopsy with indolent lymphoma in a BM biopsy. Although the diagnosis of discordance relied heavily on histopathology alone in the past, the availability of flow cytometry and molecular studies have aided the identification of this entity. The true prevalence and clinical ramifications of discordance remain controversial as available data are principally retrospective, and there is therefore little consensus to guide optimal management strategies. In this review, we examine the available literature on discordant lymphoma and its outcome, and discuss current therapeutic approaches. Future studies in discordant lymphoma should ideally focus on a large series of patients with adequate tissue samples and incorporate molecular analyses.

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Section: Introductionmentioning

confidence: 99%

Discordant bone marrow involvement in non-Hodgkin lymphoma

Brudno

Tadmor

Pittaluga

et al. 2016

Blood

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“…Examples of previously reported discordant lymphoma cases are listed in Table 2 . Hodgkin lymphomas and non-Hodgkin lymphomas have been the most commonly reported histological types in discordant lymphomas [ 4 , 11 , 12 ]. Among these combinations, several cases of B cell lymphomas and Hodgkin lymophoma combinations were reported previously.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the coexistence of lymphoma and other malignant tumors also has been reported [ 3 ]. Among the combinations of non-Hodgkin lymphoma and Hodgkin lymphoma, several cases of B cell lymphomas and Hodgkin lymophoma combinations have been reported [ 4 – 6 ]. However, in most cases, the second tumor occurs after the treatment of the first one.…”

Section: Introductionmentioning

confidence: 99%

Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report

Zhang¹,

Yi²,

Chen³

et al. 2015

Diagn Pathol

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BackgroundDiscordant lymphoma is defined by the simultaneous presence of two or more distinct types of lymphomas at different anatomic sites. With fewer than 20 studies reporting cases of discordant lymphoma to date, the incidence of this condition is believed to be very low.Case PresentationHere, we report a case of discordant lymphoma in a 34-year-old female patient that involved mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes. The patient presented with a mass in the mediastinum and enlargement of the right supraclavicular lymph nodes, but no obvious signs of lymphoma. Histological examination revealed that the encapsulated mediastinal mass contained medium- or large-size tumor cells with lightly stained cytoplasm and round vesicular nuclei as well as a high percentage of mitotic cells; strongly positive immunohistochemical staining for PAX5, CD20, and CD79a also was observed. Examination of biopsied right supraclavicular lymph node tissues revealed separation by collagen fibers, extensive inflammatory cell infiltration, and large-size tumor cells, such as Reed–Sternberg cells. These tissues stained strongly positive for PAX5 and CD30, weakly positive for CD15, and negative for Epstein-Barr viral RNA. We also found monoclonal gene rearrangement in the immunoglobulin heavy chain gene in the mediastinal large B-cell lymphoma, but no monoclonal gene rearrangement in the nodular sclerosis Hodgkin lymphoma. These findings suggested that these two lymphomas were not of a common clonal origin. The patient was treated by surgical excision of the mediastinal mass followed by radio-chemotherapy, and no metastasis or recurrence occurred during a follow-up period of 32 months.ConclusionA review of previously reported cases indicated that the clinical manifestations and pathological features of discordant lymphoma are diverse due to variation in the types of lymphomas involved. Physicians must have an awareness of discordant lymphoma to avoid incorrect and missed diagnoses, especially considering that the true incidence may not be as low as previously believed.Electronic supplementary materialThe online version of this article (doi:10.1186/s13000-015-0450-6) contains supplementary material, which is available to authorized users.

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Lymph nodes

2011

Rosai and Ackerman's Surgical Pathology

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Discordant Malignant Lymphoma Synchronous or Successive High-grade B Lymphoma Associated with Hodgkin#X2019:s Disease

Cited by 7 publications

References 26 publications

Discordant bone marrow involvement in non-Hodgkin lymphoma

Discordant bone marrow involvement in non-Hodgkin lymphoma

Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report

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