Composite inclusion complexes containing sodium alginate composite nanogels for pH-responsive valnemulin hydrochloride release

Wang, Jinhuan; Ju, Mujie; Guan, Ding; Song, Wei; Algharib, Samah Attia; Luo, Wanhe

doi:10.1016/j.molstruc.2022.133054

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…The pH of the inflammatory sites caused by SCVs infection is usually ≍5.5 [ 10 11 ]. Therefore, the release of the florfenicol-loaded CS-TPP composite nanogels in pH 5.5 and 7.4 PBS was determined to evaluate the pH-responsive release.…”

Section: Resultsmentioning

confidence: 99%

“…Nanogels are characterized by excellent structural stability and take advantage of both nanoparticles and hydrogels, such as their good response to various environmental stimuli [ 10 11 ]. Inspired by the special micro-environment of the mammary gland (e.g., pH 5.5), the responsive nanogels can improve the therapeutic drug concentrations and residence time of florfenicol and achieve targeted delivery to the infected site of SCVs [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of florfenicol composite nanogels against Staphylococcus aureus small colony variants

Liu

et al. 2022

J Vet Sci

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Background Florfenicol might be ineffective for treating Staphylococcus aureus small colony variants (SCVs) mastitis. Objectives In this study, florfenicol-loaded chitosan (CS)-sodium tripolyphosphate (TPP) composite nanogels were prepared to allow targeted delivery to SCV infected sites. Methods The formulation screening, the characteristics, in vitro release, antibacterial activity, therapeutic efficacy, and biosafety of the florfenicol composite nanogels were studied. Results The optimized formulation was obtained when the CS and TPP were 10 and 5 mg/mL, respectively. The encapsulation efficiency, loading capacity, size, polydispersity index, and zeta potential of the optimized florfenicol composite nanogels were 87.3% ± 2.7%, 5.8% ± 1.4%, 280.3 ± 1.5 nm, 0.15 ± 0.03, and 36.3 ± 1.4 mv, respectively. Optical and scanning electron microscopy showed that spherical particles with a relatively uniform distribution and drugs might be incorporated in cross-linked polymeric networks. The in vitro release study showed that the florfenicol composite nanogels exhibited a biphasic pattern with the sustained release of 72.2% ± 1.8% at 48 h in pH 5.5 phosphate-buffered saline. The minimal inhibitory concentrations of commercial florfenicol solution and florfenicol composite nanogels against SCVs were 1 and 0.25 µg/mL, respectively. The time-killing curves and live–dead bacterial staining showed that the florfenicol composite nanogels were concentration-dependent. Furthermore, the florfenicol composite nanogels displayed good therapeutic efficacy against SCVs mastitis. Biological safety studies showed that the florfenicol composite nanogels might be a biocompatible preparation because of their non-toxic effects on the renal tissue and liver. Conclusions Florfenicol composite nanogels might improve the treatment of SCV infections.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of florfenicol composite nanogels against Staphylococcus aureus small colony variants

Liu

et al. 2022

J Vet Sci

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“…It also proved the ability of the prepared enrofloxacin-loaded composite nanogels to mask their taste and reduce gastric irritation. Because the enrofloxacin was encapsulated by SA shell hydrogels, the stimulation of gastric acid was effectively avoided [ 26 , 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

Intelligent-Responsive Enrofloxacin-Loaded Chitosan Oligosaccharide–Sodium Alginate Composite Core-Shell Nanogels for On-Demand Release in the Intestine

Luo

Wang

et al. 2022

Animals

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Enrofloxacin has a poor palatability and causes strong gastric irritation; the oral formulation of enrofloxacin is unavailable, which limits the treatment of Escherichia coli (E. coli) infections via oral administration. To overcome the difficulty in treating intestinal E. coli infections, an oral intelligent-responsive chitosan-oligosaccharide (COS)–sodium alginate (SA) composite core-shell nanogel loaded with enrofloxacin was explored. The formulation screening, characteristics, pH-responsive performance in gastric juice and the intestinal tract, antibacterial effects, therapeutic effects, and biosafety level of the enrofloxacin composite nanogels were investigated. The optimized concentrations of COS, SA, CaCl2, and enrofloxacin were 8, 8, 0.2, and 5 mg/mL, respectively. The encapsulation efficiency, size, loading capacity, zeta potential, and polydispersity index of the optimized formulation were 72.4 ± 0.8%, 143.5 ± 2.6 nm, 26.6 ± 0.5%, −37.5 ± 1.5 mV, and 0.12 ± 0.07, respectively. Scanning electron microscopy images revealed that enrofloxacin-loaded nanogels were incorporated into the nano-sized cross-linked networks. Fourier transform infrared spectroscopy showed that the nanogels were prepared by the electrostatic interaction of the differently charged groups (positive amino groups (-NH3+) of COS and the negative phenolic hydroxyl groups (-COO−) of SA). In vitro, pH-responsive release performances revealed effective pH-responsive performances, which can help facilitate targeted “on-demand” release at the target site and ensure that the enrofloxacin has an ideal stability in the stomach and a responsive release in the intestinal tract. The antibacterial activity study demonstrated that more effective bactericidal activity against E. coli could have a better treatment effect than the enrofloxacin solution. Furthermore, the enrofloxacin composite nanogels had great biocompatibility. Thus, the enrofloxacin composite core-shell nanogels might be an oral intelligent-responsive preparation to overcome the difficulty in treating intestinal bacterial infections.

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Preparation of sodium alginate gel microspheres catalysts and its high catalytic performance for treatment of ciprofloxacin wastewater

Shao

Chen

et al. 2023

Chinese Journal of Chemical Engineering

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Composite inclusion complexes containing sodium alginate composite nanogels for pH-responsive valnemulin hydrochloride release

Cited by 6 publications

References 23 publications

Antibacterial activity of florfenicol composite nanogels against Staphylococcus aureus small colony variants

Antibacterial activity of florfenicol composite nanogels against Staphylococcus aureus small colony variants

Intelligent-Responsive Enrofloxacin-Loaded Chitosan Oligosaccharide–Sodium Alginate Composite Core-Shell Nanogels for On-Demand Release in the Intestine

Preparation of sodium alginate gel microspheres catalysts and its high catalytic performance for treatment of ciprofloxacin wastewater

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