Composite guar gum-silver nanoparticle hydrogels as self-healing, injectable, and antibacterial biomaterials

Talodthaisong, Chanon; Boonta, Wissuta; Thammawithan, Saengrawee; Patramanon, Rina; Kamonsutthipaijit, Nuntaporn; Hutchison, James A.; Kulchat, Sirinan

doi:10.1016/j.mtcomm.2020.100992

Cited by 45 publications

(32 citation statements)

References 50 publications

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“…In other words, the drug delivery efficiency of PPO/PEO‐C hydrogel is improved by incorporation of Ag NPs. Our findings are in agreement with the previous work obtained from low toxicity borax‐guar gum hydrogels incorporated with curcumin‐stabilized silver nanoparticles create novel biomaterials 76 . The similar phenomena are also seen in case of PEGylated AgNPs are prepared in situ by complexing AgNO 3 with the random copolymer of poly (ethylene glycol) methyl ether methacrylate (PEGMA) and polyacrylic acid via electrostatic interaction followed by in situ reduction for antibacterial application 31 …”

Section: Resultssupporting

confidence: 91%

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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This article deals with the synthesis of hybrid nanocomposite hydrogels through the combination of cellulose (C), polypropylene oxide/poly ethylene oxide (PPO/PEO), and silver nanoparticles (AgNPs) by in situ polymerization technique for the in vitro release of ornidazole drugs. The structure of the resulted materials is identified using SEM, XRD, FTIR, XPS, and TGA spectroscopic techniques. The resulting structure, morphology, thermo responsive property, water retention, and swelling behavior of hydrogels are investigated. The rheological measurement is studied to establish the enhancement of the viscoelasticity and stiffness of hydrogels. The antibacterial activity of the biodegradable silver hybrid nanocomposite hydrogel is investigated by inhibition zone method against gram positive and negative bacteria. Maximum drug release of 96.4% is recorded at 7.4 pH in 5 h. The biocompatibility and cytotoxicity of the hybrid nanocomposite hydrogel are verified using mouse fibroblast cell line L-929 (ATCC CCL-1) cells for their possible use as controlled drug delivery vehicles. The nontoxic nature makes the materials more biocompatible and suitable to apply in the biological systems. Therefore, nontoxic and biocompatible natures of present materials with improved thermal and rheological properties support for their possible uses as drug delivery vehicles.

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Section: Resultssupporting

confidence: 91%

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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“…The measured hydrodynamic sizes of all nanomaterials are larger than those measured by TEM. This may be due to the DLS experiments being undertaken in aqueous solution, where agglomeration of nanoparticles or the influence of capping molecules on the hydration sphere can be profound [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…The silver nanoparticles were prepared via a modification of a previous report [ 37 ]. Briefly, a solution of 20 mM CurBF 2 in DMSO (750 μL) was added to 68 mL of DI water in a 250 mL round bottom flask.…”

Section: Methodsmentioning

confidence: 99%

The Decoration of ZnO Nanoparticles by Gamma Aminobutyric Acid, Curcumin Derivative and Silver Nanoparticles: Synthesis, Characterization and Antibacterial Evaluation

et al. 2021

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Zinc oxide nanoparticles (ZnO NPs) are applied in various applications in catalysis, biosensing, imaging, and as antibacterial agents. Here we to prepare ZnO nanomaterials decorated by γ-amino butyric acid (GABA), curcumin derivatives (CurBF2) and silver nanoparticles (CurBF2-AgNPs). The structures of all ZnO nanostructures were characterized using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), UV–VIS spectrophotometry, fluorescence spectrophotometry, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HR-TEM). Further, their antibacterial activities against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria were investigated through analysis of minimum inhibitory concentration (MIC) method. Among the prepared nanostructures, the ZnO NPs-GABA/CurBF2-AgNPs showed excellent antibacterial activity against both Gram-positive and -negative bacteria. ZnO NPs fabricated here may have potential use in future anti-bacterial compositions and coatings technologies.

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“…Recently, silver nanoparticles have been incorporated in hydrogels and polymers for medical applications [ 15 ]. The incorporation of silver nanoparticles into hydrogels has been shown to modify gelation and antibacterial activity [ 16 , 17 , 18 , 19 ]. Curcumin is a hydrophobic poly phenolic compound exhibiting powerful biological activities [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

El‐Hady

Saeed

2020

Polymers

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A simple method was used to prepare curcumin/silver nanocomposite based chitosan hydrogel. In an alkaline medium, chitosan and chitosan nanocomposite hydrogels were prepared using the physical crosslinking method. The prepared hydrogels were stable for a long period at room temperature. In one step, silver nanoparticles were prepared insitu using silver nitrate solution and curcumin oxide within the hydrogel network formation. In the meantime, curcumin compound served as both a reducing and stabilizing agent. The structure and surface morphology of nanocomposite hydrogels were characterized by FTIR, SEM, and EDX analysis confirmed the formation of silver nanoparticles within the hydrogel network. Moreover, Images of TEM showed a spherical shape of silver nanoparticles with an average size of 2–10 nm within the matrix of the hydrogel. The formation mechanism of nanocomposite based hydrogel was reported. Besides that, the effect of chitosan and silver nitrate concentrations were studied. The swelling capacity of the prepared nanocomposite hydrogels was also performed at different pH of 4, 7, and 9. From the experimental results, the swelling capacity of hydrogels depends on the concentrations of chitosan and silver nitrate. The prepared composite based hydrogel exceeds a higher swelling degree than chitosan hydrogels at low pH. The antibacterial activity of the nanocomposite hydrogels was also examined; the results showed that the prepared nanocomposite hydrogels outperformed the pure chitosan hydrogels. This shows them to be a promising material for the biomedical field as a wound dressing and drug release.

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Composite guar gum-silver nanoparticle hydrogels as self-healing, injectable, and antibacterial biomaterials

Cited by 45 publications

References 50 publications

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

The Decoration of ZnO Nanoparticles by Gamma Aminobutyric Acid, Curcumin Derivative and Silver Nanoparticles: Synthesis, Characterization and Antibacterial Evaluation

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

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