Composite elastomeric polyurethane scaffolds incorporating small intestinal submucosa for soft tissue engineering

Da, Lincui; Gong, Maolian; Chen, Anjing; Zhang, Yi; Huang, Yi-Zhou; Guo, Zhijun; Li, Shengfu; Li‐Ling, Jesse; Zhang, Li; Xie, Huiqi

doi:10.1016/j.actbio.2017.05.041

Cited by 47 publications

(32 citation statements)

References 45 publications

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“…Polyurethanes are one of the most versatile polymers because isocyanates react with several chemical groups; this provides a way to obtain a full spectrum of applications, such as adhesives, insulation foams, coatings, and biomedical devices . Rigid polyurethane foams (rPUFs) represent a material of choice for improving the energy efficiency of buildings.…”

Section: Introductionmentioning

confidence: 99%

Highly functional lactic acid ring‐opened soybean polyols applied to rigid polyurethane foams

Herrán

Amalvy

Chiacchiarelli

2019

J of Applied Polymer Sci

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We synthesized polyols with high hydroxyl functionalities (F OH s), between 9.0 and 12.6, and characterized them with differential scanning calorimetry, thermogravimetric analysis, and size exclusion chromatography after we parametrically studied the ringopening reaction of epoxidized soybean oil with lactic acid (LA) as a function of the reaction temperature and lactic acid equivalent fraction (f LA ). An increase of only 20 C in the reaction temperature (from 80 to 100 C) caused changes in the hydroxyl number (+17.8%), F OH (-25%), viscosity (-14.0%), and oligomeric content (-24.1%). f LA mostly affected the ring-opening yield, and only for f LA values above 0.4 was possible to achieve values higher than 80%. Rigid polyurethane foams (rPUFs) were synthesized and characterized with scanning electron microscopy, dynamic mechanical analysis (DMA), and compressive mechanical tests. rPUFs with a very high specific compressive strength (7.8 kPa kg -1 m 3 ) were synthesized solely with biobased soybean oil. DMA revealed a compromised relationship between the specific compressive strength and its temperature dependence. To increase the first one, the most relevant method was to increase F OH . Instead, to increase the latter one, the OH number had to be maximized.

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Section: Introductionmentioning

confidence: 99%

Highly functional lactic acid ring‐opened soybean polyols applied to rigid polyurethane foams

Herrán

Amalvy

Chiacchiarelli

2019

J of Applied Polymer Sci

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“…The increase of compressive strength from 5.06 MPa (neat HTCP) to 9.94 MPa (HTCP treated by 10% Gel) was observed. It is important that the compressive strength of the PUR30_G_H5 scaffold (2.04 ± 0.30 MPa) ranks in the proper range for human trabecular bone (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) [28,39]. In the case of the strain after the compression of scaffolds, changes in the obtained values of tested parameters were also observed.…”

Section: Discussionmentioning

confidence: 99%

“…From 15% to 25% of PUR in the solvent, the tensile and compressive modulus was in the range of 0.1-0.8 MPa and 0.05-0.35 MPa, respectively. Additionally, Da et al [6] observed that the compressive strength of cross-linked PUR foam obtained by the lyophilization method was equal to about 0.15 MPa. In order to increase the mechanical and biological properties of PUR implants, various modificators are commonly applied.…”

Section: Introductionmentioning

confidence: 99%

Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition

et al. 2020

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The skeleton is a crucial element of the motion system in the human body, whose main function is to support and protect the soft tissues. Furthermore, the elements of the skeleton act as a storage place for minerals and participate in the production of red blood cells. The bone tissue includes the craniomaxillofacial bones, ribs, and spine. There are abundant reports in the literature indicating that the amount of treatments related to bone fractures increases year by year. Nowadays, the regeneration of the bone tissue is performed by using autografts or allografts, but this treatment method possesses a few disadvantages. Therefore, new and promising methods of bone tissue regeneration are constantly being sought. They often include the implantation of tissue scaffolds, which exhibit proper mechanical and osteoconductive properties. In this paper, the preparation of polyurethane (PUR) scaffolds modified by gelatin as the reinforcing factor and hydroxyapatite as the bioactive agent was described. The unmodified and modified scaffolds were tested for their mechanical properties; morphological assessments using optical microscopy were also conducted, as was the ability for calcification using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Moreover, each type of scaffold was subjected to a degradation process in 5M NaOH and 2M HCl aqueous solutions. It was noticed that the best properties promoting the calcium phosphate deposition were obtained for scaffolds modified with 2% gelatin solution containing 5% of hydroxyapatite.

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“…45 Hence, the tridimensional tissues prepared by inserting water-based polyurethane (synthesized from polytetramethylene ether glycol, isophorone diisocyanate, and 2,2-bis[hydroxymethyl] butyric acid) into a bio-active ECM including small intestinal submucosa have been noticed to progress tissue engineering. 45 After analyzing the structure and properties of the prepared polyurethane/small intestinal submucosa, the strength, Young's modulus, and resilience of wet polyurethane/small intestinal submucosa samples were evaluated in comparison with crosslinked polyurethane. Furthermore, the ability to increase cell attachment and proliferation of the fabricated specimens was indicated using human umbilical vein endothelial cells.…”

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confidence: 99%

“…Consequently, the prepared polyurethane/small intestinal submucosa composition showed high resilience and significant cell viability without any cytotoxicity. 45 Recently, the antibacterial properties, biocompatibility, and mechanical strength of PLLA/Ag nanocomposite prepared by electrospinning have been studied. The nanosilver solution was prepared by the biological reduction mechanism from silver nitrate (AgNO 3 ) and bitter gourd extract (reducing agent) in diphase system including a PLLA.…”

mentioning

confidence: 99%

A review of using green chemistry methods for biomaterials in tissue engineering

Jahangirian¹,

Lemraski²,

Rafiee-Moghaddam³

et al. 2018

IJN

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Although environmentally safe, or green, technologies have revolutionized other fields (such as consumables, automobiles, etc.), its use in biomaterials is still at its infancy. However, in the few cases in which safe manufacturing technology and materials have been implemented to prevent postpollution and reduce the consumption of synthesized scaffold (such as bone, cartilage, blood cell, nerve, skin, and muscle) has had a significant impact on different applications of tissue engineering. In the present research, we report the use of biological materials as templates for preparing different kinds of tissues and the application of safe green methods in tissue engineering technology. These include green methods for bone and tissue engineering-based biomaterials, which have received the greatest amount of citations in recent years. Thoughts on what is needed for this field to grow are also critically included. In this paper, the impending applications of safe, ecofriendly materials and green methods in tissue engineering have been detailed.

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Composite elastomeric polyurethane scaffolds incorporating small intestinal submucosa for soft tissue engineering

Cited by 47 publications

References 45 publications

Highly functional lactic acid ring‐opened soybean polyols applied to rigid polyurethane foams

Highly functional lactic acid ring‐opened soybean polyols applied to rigid polyurethane foams

Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition

A review of using green chemistry methods for biomaterials in tissue engineering

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