Composite Conjugated Polymer/Fullerene Nanoparticles as Sensitizers in Photodynamic Therapy for Cancer

Conducting polymer nanoparticles for targeted cancer therapy

“…It was shown previously that with the use of composite MEH-PPV/PCBM NPs for PDT, 4 hours is a sufficient time to cause nearly 100% cell mortality. 69 The measurements revealed that the viability of TE 71, MIA PaCa-2 and A549 cell lines is almost 100%. In OVCAR3 cell line, the viability decreases with increase in FNPs dose.…”

Amplified singlet oxygen generation in metallated-porphyrin doped conjugated polymer nanoparticles

“…Comprehensive reviews on CP NP characteristics and applications have been recently published [17][18][19][20]. In particular, the exceptional light harvesting and energy transfer properties of CP NP have been exploited in the development of novel O 2 ( 1 ∆ g ) photosensitizer materials used for anticancer and antibacterial treatments [18,[21][22][23][24][25][26][27][28][29][30][31]. In these particles the polymer matrix acts as efficient antenna by collecting visible (or NIR) photons and efficiently transferring excitation energy to photosensitizing dopant molecules (PS) amplifying their intrinsic O 2 ( 1 ∆ g ) generation efficiencies [17].…”