Conducting polymer nanoparticles for targeted cancer therapy

Doshi, Mona; Krienke, Marissa; Khederzadeh, Saeid; Sanchez, Henry; Copik, Alicja J.; Oyer, Jeremiah; Gesquiere, Andre J.

doi:10.1039/c5ra05125h

Cited by 24 publications

(17 citation statements)

References 67 publications

(87 reference statements)

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“…[21][22][23][24] Functional moieties on the NP surface play an important role since they determine their biological identity. [25][26] They are indispensable for attaching biomolecules to impart for instance target specificity or a stealth 5 effect.…”

Section: Introductionmentioning

confidence: 99%

PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle–Cell Interactions

et al. 2016

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Conjugated polymers have attracted significant interest in the bioimaging field due to their excellent optical properties and biocompatibility. Tailor-made poly(p-phenylenevinylene) (PPV) conjugated polymer nanoparticles (NPs) are in here described. Two different nanoparticle systems using poly[2-methoxy-5-(3',7'-dimethoxyoctyloxy)-1,4-phenylenevinylene] (MDMO-PPV) and a functional statistical copolymer 2-(5'-methoxycarbonylpentyloxy)-5-methoxy-1,4-phenylenevinylene (CPM-MDMO-PPV), containing ester groups on the alkoxy side chains, were synthesized by combining miniemulsion and solvent evaporation processes. The hydrolysis of ester groups into carboxylic acid groups on the CPM-MDMO-PPV NPs surface allows for biomolecule conjugation. The NPs exhibited excellent optical properties with a high fluorescent brightness and photostability. The NPs were in vitro tested as potential fluorescent nanoprobes for studying cell populations within the central nervous system. The cell studies demonstrated biocompatibility and surface charge dependent cellular uptake of the NPs. This study highlights that PPV-derivative based particles are a promising bioimaging probe and can cater potential applications in the field of nanomedicine.

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Section: Introductionmentioning

confidence: 99%

PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle–Cell Interactions

et al. 2016

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“…Furthermore, most of them are also biocompatible, in contrast to quantum dots [3,4]. In the last years, mainly polyfluorene [5], MEH-PPV (poly[2-methoxy-5-(2’-ethylhexyloxy)-1,4-phenylene vinylene]), CN-PPV (cyano-poly(p-phenylene vinylene)) and PPE (poly(p-phenylene ethynylene)) nanoparticles have been studied for biomedical applications [6,7,8,9,10]. Recently, different PPV NPs, i.e., MDMO-PPV (poly[2-methoxy-5-(3′,7′-dimethyloctyloxy)-1,4-phenylene vinylene]) and CPM-MDMO-PPV (2-(5’-methoxycarbonylpentyloxy)-5-methoxy-1,4-phenylene vinylene), were tested in our group [11].…”

Section: Introductionmentioning

confidence: 99%

Fluorescent PCDTBT Nanoparticles with Tunable Size for Versatile Bioimaging

et al. 2019

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Conjugated polymer nanoparticles exhibit very interesting properties for use as bio-imaging agents. In this paper, we report the synthesis of PCDTBT (poly([9-(1’-octylnonyl)-9H-carbazole-2,7-diyl]-2,5-thiophenediyl-2,1,3-benzothiadiazole-4,7-diyl-2,5-thiophene-diyl)) nanoparticles of varying sizes using the mini-emulsion and emulsion/solvent evaporation approach. The effect of the size of the particles on the optical properties is investigated using UV-Vis absorption and fluorescence emission spectroscopy. It is shown that PCDTBT nanoparticles have a fluorescence emission maximum around 710 nm, within the biological near-infrared “optical window”. The photoluminescence quantum yield shows a characteristic trend as a function of size. The particles are not cytotoxic and are taken up successfully by human lung cancer carcinoma A549 cells. Irrespective of the size, all particles show excellent fluorescent brightness for bioimaging. The fidelity of the particles as fluorescent probes to study particle dynamics in situ is shown as a proof of concept by performing raster image correlation spectroscopy. Combined, these results show that PCDTBT is an excellent candidate to serve as a fluorescent probe for near-infrared bio-imaging.

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“…Finally, Gesquiere and coworkers used MEH-PPV (see Figure 6 ) as a photosensitizer for photodynamic therapy [ 69 , 70 ]. Due to its high extinction coefficient and easy intersystem crossing to the triplet state, ROS are readily generated.…”

Section: Recent Developments In Bioimaging With Cpnpsmentioning

confidence: 99%

Conjugated Polymer Nanoparticles for Bioimaging

et al. 2017

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During the last decade, conjugated polymers have emerged as an interesting class of fluorescence imaging probes since they generally show high fluorescence brightness, high photostability, fast emission rates, non-blinking behavior and low cytotoxicity. The main concern related to most conjugated polymers is their lack of hydrophilicity and thereby poor bio-availability. This can, however, be overcome by the formulation of conjugated polymer nanoparticles in aqueous medium. This review provides an overview of the different techniques employed for the preparation of conjugated polymer nanoparticles, together with methods to improve their photoluminescence quantum yields. For selective targeting of specific cells, dedicated surface functionalization protocols have been developed, using different functional groups for ligand immobilization. Finally, conjugated polymer nanoparticles have recently also been employed for theranostic applications, wherein the particles are simultaneously used as fluorescent probes and carriers for anti-tumor drugs.

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Conducting polymer nanoparticles for targeted cancer therapy

Abstract: Functionalized conducting polymer nanoparticles allow for targeted delivery, tracking by fluorescence bioimaging, and therapeutics through formation of reactive oxygen species.

Cited by 24 publications

References 67 publications

PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle–Cell Interactions

PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle–Cell Interactions

Fluorescent PCDTBT Nanoparticles with Tunable Size for Versatile Bioimaging

Conjugated Polymer Nanoparticles for Bioimaging

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