Composite Biopolymer-Based Wafer Dressings Loaded with Microbial Biosurfactants for Potential Application in Chronic Wounds

Akiyode, Olufunke; Boateng, Joshua

doi:10.3390/polym10080918

Cited by 24 publications

(27 citation statements)

References 43 publications

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“…diabetic foot ulcers (DFUs) due to their biocompatible, adhesive, antibacterial and hemostatic properties. 112,114,116,117 The purpose of the study proposed by Akiyode and Boateng 112 was to investigate two bioactive polysaccharide polymers kappa-carrageenan (CARR) and sodium alginate (SA) incorporated with microbial biosurfactants (BSs) as medicated wafer dressings for potential application in chronic wounds. Wafers were loaded with BSs at concentrations of 0.1% and 0.2% rhamnolipids (RL) and 0.1% and 5% sophorolipids (SL).…”

Section: Mucoadhesive Drug Delivery Systemsmentioning

confidence: 99%

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Jadach¹,

Świetlik²,

Froelich³

2022

Journal of Pharmaceutical Sciences

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Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as well as low production cost and good availability. One of the most important features typical for alginates is the ability to undergo ionotropic gelation which is gel formation process occurring upon the contact with cations. Because of their advantageous properties, alginates have been extensively utilized in food and pharmaceutical industries. In this review the current knowledge regarding the most recent studies involving both popularly applied dosage forms, like tablets or hydrogels, and novel advanced drug delivery systems applied in targeted therapies are summarized and discussed. The presented studies indicate that although sodium alginate is a well-established polymer, it is still widely applied as pharmaceutical excipient and the presented research studies indicate that there are still research areas that can be explored and provide innovation in drug delivery systems.

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Section: Mucoadhesive Drug Delivery Systemsmentioning

confidence: 99%

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Jadach¹,

Świetlik²,

Froelich³

2022

Journal of Pharmaceutical Sciences

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“…Similarly, the ability to control the water loss at an ideal rate is also important for wound dressings [40]. Therefore, the W R of various BC/AgNW dressings was estimated (Fig.…”

Section: Morphology Structure and Physiochemical Propertiesmentioning

confidence: 99%

Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

Wan

Yang

Wang

et al. 2020

Composites Part B: Engineering

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While silver nanoparticles are widely used to endow materials with antibacterial activity, silver nanowires (AgNWs) have not attracted much attention. Herein, the composites of bacterial cellulose (BC) and AgNWs were prepared through a novel step-by-step in situ biosynthesis which retains the three-dimensional network of BC. The results of water vapor permeability, water uptake rate, and water retention rate showed that the BC/AgNW wound dressings could absorb wound skin exudates and maintain moisture environments. Furthermore, the BC/ AgNW dressings were robust and stretchable. More importantly, the BC/AgNW dressings exhibited sustained release of Ag +. The results from animal tests indicated that the BC/AgNW dressing with 38.4 wt% AgNWs exhibited higher expression levels of cytokeratin-10 and integrin-β4, greater proliferation of keratinocytes and formation of epithelial tissues and greatly improved skin regeneration over the bare BC. We propose that the integrated nanofibrous structure and the excellent and sustained antibacterial activity of AgNWs are responsible for the excellent in vivo wound healing ability and biocompatibility. These results suggest that the BC/AgNW composites have promising application as wound dressings.

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“…SWF was prepared as documented earlier. [42][43][44] The pH was adjusted to prepare SWF with various pH (3 to 9). Around 5 lL of this SWF was dropped on the test pad of the device and the color change observed.…”

Section: In Vitro Testing Of Detec ò Ph Performancementioning

confidence: 99%

A Device to Predict Short-Term Healing Outcome of Chronic Wounds

Tran

Pal

et al. 2020

Advances in Wound Care

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Objective: While myriads of studies have suggested that a survey of wound pH environment could indicate wound healing activities, it is not clear whether wound alkalinity can be used as a prognostic indicator of nonhealing wounds. Currently available systems cannot reliably assess the pH environment across wounds, which is the objective of this study. Approach: A disposable device, DETEC Ò pH, was developed and characterized on its ability to map wound alkalinity by pressing a freshly recovered wound dressing against its test surface. By comparing the wound's alkalinity and size reduction rates (*7 days) following pH measurement, we assessed the capability of wound alkalinity to prognosticate subsequent short-term wound size reduction rates. Results: The device had high accuracy and specificity in determining the alkalinity of simulated wound fluids soaked onto wound dressing. The type of wound dressing type had an insignificant effect on its detection sensitivity. Upon testing discarded wound dressings from human patients, the device quickly determined alkaline and acidic wounds. Finally, statistical analyses of wound size reduction rates in wounds with various alkalinities confirmed that wound alkalinity has a strong influence on, at least, short-term wound healing activity. Innovation: Without directly contacting the patient, this device provides a quick assessment of wound alkalinity to prognosticate immediate and short-term wound healing activities. Conclusion: DETEC Ò pH may serve as a prognosis device for wound care specialists during routine wound assessment to predict wound healing progress. This information can assist the decision-making process in a clinical setting and augur well for chronic wound treatment. DETEC Ò pH can also be used as an aid for home health care nurses or health care providers to screen nonhealing wounds outside clinics.

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Composite Biopolymer-Based Wafer Dressings Loaded with Microbial Biosurfactants for Potential Application in Chronic Wounds

Cited by 24 publications

References 43 publications

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose

A Device to Predict Short-Term Healing Outcome of Chronic Wounds

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