Comportamento biológico de matriz scaffold acrescida de células progenitoras na reparação óssea

Olsson, Débora Cristina; Pippi, Ney Luís; Tognoli, Guilherme Kanciukaitis; Raiser, Alceu Gaspar

doi:10.1590/s0103-84782008000800051

Cited by 7 publications

(9 citation statements)

References 42 publications

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“…According to literature, bone-marrow grafts are most efficient due to their higher content of osteoprogenitor cells [63]. They can be obtained by both extraoral (iliac crest, tibia or skull) or intraoral areas (retromolar region, mandibular symphisys and maxillary tuberosities), depending on the volume and composition of the desired graft [10].…”

Section: Originmentioning

confidence: 99%

“…Synthetic grafts are associated to an osteoconductive action, characterized by bone growth into the graft material matrix, which acts as a scaffold to the regeneration of lost bone tissue [16,61,63,69].…”

Section: Originmentioning

confidence: 99%

“…They are known as bioactive materials, due to their capacity of actively participating on both cicatrization and regeneration of bone tissue [74]. This capacity results from the similarity between calcium phosphate materials and the apatites found on bone tissue [23,63,69].…”

Section: Biomaterials Based On Calcium Phosphatementioning

confidence: 99%

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Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

Salgado¹,

Sathler²,

Castro³

et al. 2011

JBNB

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Presently, several different graft materials are employed in regenerative or corrective bone surgery. However current misconceptions about these biomaterials, their use and risks may compromise their correct application and development. To unveil these misconceptions, this work briefly reviewed concepts about bone remodeling, grafts classification and manufacturing processes, with a special focus on calcium phosphate materials as an example of a current employed biomaterial. Thus a search on the last decade was performed in Medline, LILACS, Scielo and other scientific electronic libraries using as keywords biomaterials, bone remodeling, regeneration, biocompatible materials, hydroxyapatite and therapeutic risks. Our search showed not only an accelerated biotechnological development that brought significant advances to biomaterials use on bone remodeling treatments but also several therapeutic risks that should not be ignored. The biomaterials specificity and limitations to clinical application point to the current need for developing safer products with better interactions with the biological microenvironments

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Section: Originmentioning

confidence: 99%

Section: Originmentioning

confidence: 99%

See 1 more Smart Citation

Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

Salgado¹,

Sathler²,

Castro³

et al. 2011

JBNB

View full text Add to dashboard Cite

show abstract

“…Oh et al (2010) (OLIVER et al, 2004;OLSSON et al, 2008;LARANJEIRA;DE FÁVERE, 2009 (REYES et al, 2001;PARTRIDGE et al, 2002;ALHADLAQ;MAO, 2004;MEINEL et al, 2004;IM et al, 2005;VIDAL et al, 2006).…”

Section: Osteossintese Em Ossos Longos Nos Equinosmentioning

confidence: 99%

“…Já o enxerto osteocondutor, geralmente é inorgânico e permite o crescimento de tecido ósseo em sua superfície, requerendo para isso tecido ósseo pré-existente como fonte de células osteo-progenitoras (OLSSON et al, 2008).…”

Section: Osteossintese Em Ossos Longos Nos Equinosunclassified

Avaliação da resistência mecânica à compressão axial da poliuretana de mamona e quitosana associada a cimento de fosfato de cálcio no preenchimento de falhas ósseas do terceiro metacarpiano de equinos

Moreira¹

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decreased from 2260.64µd to 320.25µd and from 2260.64µd to 89.88µd following filling of the bone defect with RCP or CPC-chitosan composite respectively. Bone deformation around the defect increased following treatment with RCP or CPCchitosan composite. However bone deformation away from the defect remained unchanged. Maximum load within the elastic limit increased from 1008N to 8804N when the experimental defect was filled with chitosan composite. Conversely, construct deformation within the elastic limit decreased from 1.64mm to 1.26mm following treatment with RCP. Maximum load to construct failure increased from 1660N to 15187N and 11012N following bone defect repair with RCP or calcium phosphate cement-chitosan composite respectively. However, construct maximum deformation decreased from 5.4mm to 2.16mm when calcium phosphate cementchitosan composite was used.

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Hematopoietic progenitor constituents and adherent cell progenitor morphology isolated from black‐rumped agouti (Dasyprocta prymnolopha, Wagler 1831) bone marrow

Rocha

Alves

Neto

et al. 2012

Microscopy Res & Technique

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Stem cells are present in the adult tissues of most diverse species. Bone marrow is recognized to be the most exploited site to obtain stem cells and cell progenitors. The objective of the present study was to characterize hematopoietic progenitor (HP) morphology and analyze the performance of adherent cell progenitors (ACPs) cultivated in vitro from black-rumped agouti bone marrow (Dasyprocta prymnolopha). Bone marrow aspirates were obtained from tibia crest and used to prepare histological slides and identify cell morphology. Cells were also scattered on culture plates for later isolation, expansion, and quantification. Smears obtained from bone marrow demonstrated HPs at different stages of maturity. In culture, these cells showed fibroblastoid morphology and a strong tendency to form colonies, demonstrated by the presence of cell aggregates, cytoplasmic elongations lying side by side. An 80% cell confluence was observed at 18 days in culture and progressive reduction in the percentage of nonadherent mononuclear cells. After eight passes, a mean cell viability of 96.07% was observed, from a pool of 1.6 × 10(7) cells (ACP). Thirteen 25-cm(2) culture bottles were trypsinized, resuspended in freezing medium, stored in 14 criotubes at a concentration of 1 × 10(6) cells per milliliter, and placed in liquid nitrogen at -196°C. Agouti bone marrow demonstrated high plasticity, moreover different HP lines, and a population of adherent cells demonstrated morphology similar to mesenchymal stem cells in culture.

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Comportamento biológico de matriz scaffold acrescida de células progenitoras na reparação óssea

Cited by 7 publications

References 42 publications

Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

Avaliação da resistência mecânica à compressão axial da poliuretana de mamona e quitosana associada a cimento de fosfato de cálcio no preenchimento de falhas ósseas do terceiro metacarpiano de equinos

Hematopoietic progenitor constituents and adherent cell progenitor morphology isolated from black‐rumped agouti (Dasyprocta prymnolopha, Wagler 1831) bone marrow

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