Complications of tetracycline therapy

C, Olson; Riley, Harris D.

doi:10.1016/s0022-3476(66)80454-7

Cited by 35 publications

(11 citation statements)

References 44 publications

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“…The development of tachyphylaxia is possibly due to either depletion of histamine or accumulation of doxy cycline and its metabolites in the body. This finding supports the hyper sensitivity reactions reported as untoward effects of doxycycline in the clinical practice [4].…”

Section: Discussionsupporting

confidence: 88%

“…On one hand, this pattern resembles the effect of calcium ion in differ ent concentrations on the excitation-contraction coupling process of smooth muscle, while the dose-effect curve of oxytetracycline was shown to have a more or less hyperbolic shape [1]. On the other hand, it has been demonstrated that doxycycline, with a very high liposolubility coef ficient of 475, has a lower calcium affinity (19-22%) compared to oxytetracycline, which has a very low liposolubility coefficient of 7.2 and calcium affinity of 36% [4,8].…”

Section: Discussionmentioning

confidence: 99%

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Pharmacological Effects of Doxycycline on the Mammal’s Intestine and Cardiovascular System

Guiti¹,

Abtahi²

1973

Chemotherapy

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The effects of doxycycline were studied on the spontaneous contractions of the rabbit’s isolated jejunum and heart, on the carotid blood pressure and femoral venous outflow in the dog and the rabbit. The dose-response curve of the intestine showed a hyperbolic shape. The amplitude of cardiac contractions was depressed. A peripheral vasodilatation in dogs and vasoconstriction in rabbits was observed. By use of the blocking agents, it was found that this antibiotic acts on intestinal muscle receptors independently of cholinergic and adrenergic mechanisms and showed a histaminergic effect on the peripheral vascular system. The possible effect of doxycycline as Ca binding is discussed.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Pharmacological Effects of Doxycycline on the Mammal’s Intestine and Cardiovascular System

Guiti¹,

Abtahi²

1973

Chemotherapy

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“…The absorption of benzyl penicillin is reduced when a dose is given closely related in time to a meal because of increased destruction by gastric acid (Weiss, Nadel, Eisenberg & Flippin, 1959). Likewise, in the case of the tetracyclines, the concomitant oral adminiistration of calcium, magnesium or aluminium ions, either in the diet or for unrelated medicinal purposes, will adversely affect albsorption due to the formation of insoluible complexes (Current Practice, 1968 ;Mull, 1966;Olson & Riley, 1966). Therapeutic levels are still achieved even under such conditions, however, by penicillin G and the tetracyclines.…”

Section: Discussionmentioning

confidence: 99%

Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic

Gower¹,

Dash²

1969

British J Pharmacology

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. Serum levels, half‐lives and urine concentrations of cephalexin, an oral cephalosporin antibiotic which is unique in its absorption and excretion, are reported in human volunteers, fasting, non‐fasting and non‐fasting plus probenecid. Accumulation does not seem to occur. . Cephalexin clearance was 376 ml./min and the ratio of cephalexin/creatinine clearances was 2·6 in one volunteer. . Cephalexin had no effect on the urinary excretion of leucocytes, red cells or protein. . The very high rate of absorption giving high serum levels and urine concentrations suggest cephalexin will be a useful antibiotic in susceptible bacterial infections in man.

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“…Clinical evidence has shown that tetracyclines cause tooth discolouration when prescribed during tooth development as they bind to calcified structures. The resulting tooth colour change depends on the dosage and type of tetracycline but generally the outcome is bluish-grey stain affecting the part of the tooth which was being formed during the period of tetracycline use 14 . Dental fluorosis is one of the most common causes of intrinsic discolouration, arising endemically from water sources or fluoride in toothpastes, mouthwashes and supplements 15 .…”

Section: Intrinsic Effectsmentioning

confidence: 99%

The clinical measurement of tooth colour and stain

Brook¹,

Smith²,

Lath³

2007

International Dental Journal

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There are many contributory factors to tooth colour and different techniques for its measurement. The aim of this paper is to evaluate methods of tooth colour and stain measurement, with an emphasis on recent advances in objective clinical measurement techniques. The overall colour effect of natural teeth is created by a combination of light which is reflected and scattered by tooth enamel and the underlying dentine. Developmental defects of the dentition can affect the intrinsic discolouration of teeth, for example, amelogenesis imperfecta and dentinogenesis imperfecta. Extrinsic discolouration is predominantly caused by stain build up on a tooth surface from bacteria, foodstuffs or metalic compounds. Tooth colour and stain measurement are currently assessed using a wide range of measurement methods divided into subjective (visual shade matching) and objective instrumental assessment such as by colourimetry, spectrophotometry and digital image analysis. The most popular method of assessing tooth colour clinically is visual shade matching, as this approach is quick and simple to use. However, variation in results can occur as a consequence of the subjective nature of this method. The instrumental approaches including quantitative light-induced fluorescence remove or significantly reduce the subjective component. Image analysis appears to be the most suitable method for tooth colour measurement and further work is being carried out to establish this approach.

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Complications of tetracycline therapy

Cited by 35 publications

References 44 publications

Pharmacological Effects of Doxycycline on the Mammal’s Intestine and Cardiovascular System

Pharmacological Effects of Doxycycline on the Mammal’s Intestine and Cardiovascular System

Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic

The clinical measurement of tooth colour and stain

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