Complications of Diabetes Mellitus

Brownlee, Michael; Aiello, Lloyd Paul; Cooper, Mark E.; Vinik, Aaron I.; Plutzky, Jorge; Boulton, Andrew J.M.

doi:10.1016/b978-0-323-29738-7.00033-2

Cited by 29 publications

(31 citation statements)

References 935 publications

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“…VEGF is able to participate in early angiogenesis regulation of DKD, which may be related to various pathological changes such as glomerular hypertrophy, renal interstitial damage, and increased urine protein (Nasu et al, 2009). Studies have shown that the levels of VEGF-A in the renal cortex of diabetic mice and Vash1 +/-mice has been increased, and Vash1 gene knockout presented the same phenomenon, leading to the deterioration of DKD (Brownlee et al, 2016). Other studies have also suggested that increased VEGF-A compensated for renal microvascular damage (Onami et al, 2013), indicating that VASH-1 can play a renal protective role by regulating VEGF.…”

Section: Discussionmentioning

confidence: 99%

“…Vasohibin-1 (VASH-1) is an emerging anti-angiogenic factor produced and secreted by endothelial cells with the target protein, vascular endothelial growth factor (VEGF) (Akgun and Ertel, 1985). Recent reports show that VASH-1 is present in glomeruli mesangial cells as well (Bergers and Hanahan, 2008), and VASH-1 also plays a potential protective role in kidney diseases via negative feedback (Brownlee et al, 2016). One recent study has indicated that silence information adjustment factor 2-related enzyme 1 (Sirtuin 1, SIRT1) and superoxide dismutase 2 (SOD2) are also two important downstream targets for VASH-1 (Chen et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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VASH-1 Regulates Oxidative Stress and Fibrosis in Diabetic Kidney Disease via SIRT1/HIF1α and TGFβ1/Smad3 Signaling Pathways

Ren

Shao

et al. 2020

Front. Mol. Biosci.

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Aims: To investigate the role of Vasohibin-1 (VASH-1), silence information adjustment factor 2-related enzyme 1 (SIRT1)/hypoxic-inducible factor 1α (HIF1α) and transforming growth factor-β1 (TGFβ1) /Smad3 signaling pathways in oxidative stress and fibrosis of diabetic kidney disease (DKD). Materials and Methods: A diabetic rat model was established in vivo and rat mesangial cells (RMCs) were cultured in vitro with high glucose via transfection with Vash1 small interfering RNA (siRNA), Hif1a siRNA, Sirt1 siRNA and TGFβ1/Smad3 pathway inhibitor (SB431542). Renal histology was used to detect renal changes. Real-time PCR and western blot were used to analyze the expression of VASH-1, SIRT1, HIF1α, TGFβ1, Smad3, vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF) and fibronectin (FN). Expression levels of tumor necrosis factor-α (TNFα), TGFβ1, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX), and malondialdehyde (MDA) in rat tissues and cell culture supernatant were detected by ELISA and chemiluminescence assay, while cell proliferation was detected by CCK-8. Results: The level of VASH-1 in renal tissues of diabetic rats was decreased, while both high glucose and Vash1 siRNA inhibited the expression of VASH-1 and SIRT1, increased the levels of HIF1α, TGFβ1, and Smad3 in RMCs, thus up-regulating oxidative stress and fibrosis factors, and abnormally increasing cell proliferation activity (P < 0.05). However, inhibition of SIRT1/HIF1α signaling pathway only reduced TGFβ1 and Smad3 (P < 0.05), while VASH-1 remained unchanged (P > 0.05). Conclusion: VASH-1 was under-expressed in renal tissues of diabetic rats and regulated the pathological process of oxidative stress and fibrosis in DKD via downstream SIRT1/HIF1α and TGFβ1/Smad3 signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

VASH-1 Regulates Oxidative Stress and Fibrosis in Diabetic Kidney Disease via SIRT1/HIF1α and TGFβ1/Smad3 Signaling Pathways

Ren

Shao

et al. 2020

Front. Mol. Biosci.

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“…golden yellow). The principal fatty acids are: arachidic (3%), essential for synthesis of various hormones, such as prostaglandins, thromboxanes, and leukotrienes; 33 linoleic (19-26%), an important constituent of neuronal membrane phospholipids and a precursor of prostaglandins; 34 oleic (48-49%), modifies plasma lipid and lipoprotein concentrations, inhibits coagulation, improves glucose homeostasis, and attenuates inflammation; 35 stearic (7-10%), does not increase atherosclerosis risk and is associated with reduced blood pressure and improved heart function; 36 and palmitic acid (12-14%), has shown anti-inflammatory and lipid lowering effects linked to the prevention of metabolic syndrome, cardiovascular disease and insulin resistance associated with diabetes and obesity. 37 As reported by van der Maesen, 28 100 g dry weight of defatted marama bean seed meal contains 194 kJ (i.e.…”

Section: Fatty Acids In Marama Bean and Their Functionsmentioning

confidence: 99%

Marama bean [Tylosema esculentum (Burch.) A. Schreib.]: an indigenous plant with potential for food, nutrition, and economic sustainability

Omotayo

Aremu

2021

Food Funct.

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“…DR is typically diagnosed at a late stage when treatment options are limited. Due to its asymptomatic onset and progressive disease course, DR often results in irreversible blindness, which has a shortage of effective treatment due to the complex nature of the disease and limited knowledge of its pathogenic mechanism ( 3 – 5 ). Therefore, finding an effective treatment for DR has important clinical significance.…”

Section: Introductionmentioning

confidence: 99%

Carnosine improves diabetic retinopathy via the MAPK/ERK pathway

Guo

et al. 2019

Exp Ther Med

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Diabetic retinopathy (DR) is one of the most common causes of blindness in developed countries. Due to its asymptomatic onset and progressive disease course, DR is typically diagnosed at a late stage when treatment options are limited and therefore often results in irreversible blindness. Studies have demonstrated that carnosine may prevent and treat DR. In a previous study, the positive effect of carnosine on DR was determined and it was revealed that there may be an association between carnosine and the mitogen-activated protein kinase (MAPK)/extracellular signal related kinase (ERK) signaling pathway. To assess the interaction between carnosine and the MAPK/ERK signaling pathway, changes in PKC, ERK and p-ERK expression was assessed in diabetic rats following treatment with carnosine, PD98059 or U46619 via reverse transcription-quantitative polymerase chain reaction and western blotting. The results demonstrated that the expression of ERK and p-ERK were significantly suppressed following treatment with carnosine, but no significant effect on the expression of PKC was identified, which indicates that suppressing the activation of the MAPK/ERK signaling pathway may serve an important role in carnosine-induced DR prevention and treatment.

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Complications of Diabetes Mellitus

Cited by 29 publications

References 935 publications

VASH-1 Regulates Oxidative Stress and Fibrosis in Diabetic Kidney Disease via SIRT1/HIF1α and TGFβ1/Smad3 Signaling Pathways

VASH-1 Regulates Oxidative Stress and Fibrosis in Diabetic Kidney Disease via SIRT1/HIF1α and TGFβ1/Smad3 Signaling Pathways

Marama bean [Tylosema esculentum (Burch.) A. Schreib.]: an indigenous plant with potential for food, nutrition, and economic sustainability

Carnosine improves diabetic retinopathy via the MAPK/ERK pathway

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