Complications of dermal fillers injection in facial augmentation: international and Russian experience

Karpova, Elena I.; Потекаев, Н. Н.; Murakov, S.V.; Danishchuk, O. I.; Demina, O. M.

doi:10.17116/plast.hirurgia201904154

Cited by 15 publications

(2 citation statements)

References 59 publications

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“…The literature and photographic searches yielded 243 individual photographic cases with a total of 738 photographs available for review and scoring using the FOEM system. Information relating to patient demographics was available in 199 cases, filler material and injection site in 195 cases, and symptoms in 149 cases from 120 publications 23–143 from which data extraction was performed and are listed in Table 2. The patient population was predominantly female (88%), with an average age of 38.2 years.…”

Section: Resultsmentioning

confidence: 99%

“Patterns of filler-induced facial skin necrosis: A systematic review of 243 cases and introduction of the F.O.E.M. scoring system and grading scale.”

Soares¹,

Bowhay²,

Blevins³

et al. 2022

Plastic &Amp; Reconstructive Surgery

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Background: The incidence of facial skin necrosis has increased considerably because of the growth in the popularity of dermal fillers. This study describes the patterns and severity of facial skin ischemia, along with associated neuro-ophthalmologic injuries, in the published literature through the introduction of the facial artery, ophthalmic artery, distal external carotid artery, internal maxillary artery (FOEM) facial angiosome scoring system and grading scale. Methods: A systematic review of all photographic cases of facial skin ischemia attributable to vascular occlusion with dermal fillers and injectable materials was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Results: A total of 243 cases were identified, with 738 digital clinical photographs retrieved. The facial artery (58% of cases) and ophthalmic artery (48% of cases) angiosomes were most commonly affected. The frontonasal and angulonasal territories were the most common facial skin segments injured by filler-induced vascular occlusion. Cutaneous involvement of the ophthalmic angiosome was significantly associated with neuro-ophthalmologic complications [vision loss, 39% versus 0.8% (P = 0.00001); stroke, 8% versus 0.8% (P = 0.0085)]. Injuries with greater cutaneous surface area or cross-angiosome involvement were associated with a higher incidence of severe visual deficits and bilateral stroke. Conclusions: Facial skin necrosis attributable to vascular occlusion is a rapidly growing problem that has remained poorly characterized in the literature. This study provides the largest descriptive analysis of published photographic reports of skin ischemia to date and proposes a novel scoring system and grading classification to aid in future reporting.

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Section: Resultsmentioning

confidence: 99%

“Patterns of filler-induced facial skin necrosis: A systematic review of 243 cases and introduction of the F.O.E.M. scoring system and grading scale.”

Soares¹,

Bowhay²,

Blevins³

et al. 2022

Plastic &Amp; Reconstructive Surgery

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show abstract

“…In the modern world, the development of methods of prevention and treatment of age-related changes in the skin and activation of regenerative processes is relevant and has great scientific and practical significance, but due to the specificity of the molecular response, the principles of control and regulation of inflammation processes have not been fully studied. The number of complications after the introduction of various drugs into human skin increases [1,2].…”

mentioning

confidence: 99%

Rat skin inflammation markers change in response to calcium hydroxyapatite and hyaluronic acid administration

Larkina

Seletskaya

Макаренко³

et al. 2021

J Educ Health Sport

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In the research, the level of some markers of skin inflammation in Wistar rats was examined after injection of calcium hydroxyapatite and hyaluronic acid drugs of various concentrations, where the nature, degree, extent of tissue damage and the general condition of the animals in general were close to humans’. Each drug was evaluated according to several indicators (MDA content, activity of neutrophil elastase, acid phosphatase, and catalase) to understand the measure of the adequacy of the body's response to the intensity of the stimulus. A biochemical analysis of the skin of laboratory rats after the injection of the studied drugs showed that the safest drugs contain nonstabilized 4% hyaluronic acid. Either in pure form or in a 1: 1 mixture with calcium hydroxyapatite at a concentration of 55.7%, since in 2 months after their injection in the skin of experimental animals, markers of inflammation (elastase, acid phosphatase and MDA levels), catalase and API activity were found at the normal level. The injection of drugs containing stabilized 2% hyaluronic acid and calcium hydroxyapatite 55.7%, as well as stabilized 2.6% hyaluronic acid and calcium hydroxyapatite at a concentration of 1% caused prolonged LPO activation, increased level of inflammation markers and decreased API. The injection of calcium hydroxyapatite drugs without hyaluronic acid, even at a 1: 1 dilution with saline, also caused prolonged LPO activation, an increased level of inflammation markers and a decreased API, and, in addition, revealed a significant increase in acid phosphatase activity, which is an indicator of the integrity of cell membranes. The obtained results made it possible to analyze the features of the molecular response and regulation of inflammation upon injection of calcium hydroxyapatite and hyaluronic acid drugs of different concentrations, which will help in prescribing of treatment.

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Prospective randomized single-center study of safety and efficacy of hyaluronic acid products in age-related facial skin changes

Gabueva¹

2022

Klin. dermatol. venerol.

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Complications of dermal fillers injection in facial augmentation: international and Russian experience

Cited by 15 publications

References 59 publications

“Patterns of filler-induced facial skin necrosis: A systematic review of 243 cases and introduction of the F.O.E.M. scoring system and grading scale.”

“Patterns of filler-induced facial skin necrosis: A systematic review of 243 cases and introduction of the F.O.E.M. scoring system and grading scale.”

Rat skin inflammation markers change in response to calcium hydroxyapatite and hyaluronic acid administration

Prospective randomized single-center study of safety and efficacy of hyaluronic acid products in age-related facial skin changes

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