Complications of chronic ulcerative colitis

Local Complications of Ulcerative Colitis: Stricture, Pseudopolyposis, and Carcinoma of Colon and Rectum

“…A similar high incidence of pseudopolyposis has been found in other surveys (Sloan et al, 1950 ;Brown, Kasich, and Weingarten, 1951 ;Van Prohaska and Siderius, 1962).…”

Intraperitoneal Perforation of the Colon in Ulcerative Colitis [Abridged]

“…Patients with a severe first attack and total involvement of the colon and rectum had an even higher risk of perforation; nearly one in five of them (19-2%) perforated during the primary onset. Site ofperforation: Previous series in which the site of perforation is stated (Sloan et al 1950, Brown: et al 1951, Bruce & Cole 1962 show an even distribution throughout the colon, it being slightly more common in the transverse than elsewhere. Both the present series and that of Edwards & Truelove (1964) suggest that the commonest site is in the sigmoid colon, 11 of our 13 patients having at least one perforation at this site.…”

“…In recent years smaller series of perforations have been published in which cases have been described in greater detail (Brown et al 1951, Ripstein 1954, Lumb et al 1955, Brooke 1956, Bruce & Cole 1962, Hickey et al 1963, Edwards & Truelove 1964. It is now widely accepted that intraperitoneal perforation of the colon is the most lethal local complication of acute ulcerative colitis.…”

The course and prognosis of ulcerative colitis: Part II Long-term prognosis

“…We have preferred to calculate expected fatality rates on the basis of the Registrar General's data for the general population to act as a measure of how much ulcerative colitis worsens the expectation of life. The expected fatality rate for our series of patients was calculated on the basis of the death rates from all causes per 1,000 living, which are given separately by age group and by sex, for the five-year period 1951-55 (Registrar General, 1963. Table XXII and Fig.…”

“…With them, the initial risk is nowadays low difficult to compare their results with those obtained and emergency surgery would almost certainly be in the present study for various reasons. Some more dangerous than conservative management; but studies have achieved a poor percentage follow-up the unfavourable long-term course suggests the (Gleckler and Brown, 1950;Brown, Kasich, and possibility that elective colectomy should be con-Weingarten, 1951; Dennis and Karlson, 1952; sidered in such patients once the acute attack is over. Flood, Lepore, Hiatt, and Karush, 1956;Dawson The objection to regarding the widespread and Pryse-Davies, 1959).…”