Complications of Antibiotic Therapy

Wright, Jenny; Paauw, Douglas S.

doi:10.1016/j.mcna.2013.02.006

Cited by 41 publications

(35 citation statements)

References 45 publications

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“…However, all pharmacological approaches bear the risk of unwanted side effects such as antibiotic-associated diarrhea in patients treated with amoxicillin-clavulanate, or more severe risks such as cephalosporin-induced (cefotetan) immune hemolytic anemia, drug-induced liver toxicity due to various antimicrobial agents (sulfonamides, macrolides, quinolones) and kidney injury caused by aminoglycosides, vancomycin and others [23].…”

Section: Discussionmentioning

confidence: 99%

“…Recommended antibiotic therapies to treat these conditions are either by multiple doses of tetracycline or a single dose of azithromycin [10]. However, a recent study has found that the risk of cardiovascular death in patients on azithromycin is elevated compared to patients treated with amoxicillin or ciprofloxacin [23], [24]. Another well-known factor limiting the efficacy of antimicrobial treatment is the development of antibiotic resistance through acquisition of resistant determinants by horizontal gene transfer and/or other mechanisms [25].…”

Section: Discussionmentioning

confidence: 99%

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Water-Filtered Infrared A Irradiation in Combination with Visible Light Inhibits Acute Chlamydial Infection

et al. 2014

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New therapeutic strategies are needed to overcome drawbacks in treatment of infections with intracellular bacteria. Chlamydiaceae are Gram-negative bacteria implicated in acute and chronic diseases such as abortion in animals and trachoma in humans. Water-filtered infrared A (wIRA) is short wavelength infrared radiation with a spectrum ranging from 780 to 1400 nm. In clinical settings, wIRA alone and in combination with visible light (VIS) has proven its efficacy in acute and chronic wound healing processes. This is the first study to demonstrate that wIRA irradiation combined with VIS (wIRA/VIS) diminishes recovery of infectious elementary bodies (EBs) of both intra- and extracellular Chlamydia (C.) in two different cell lines (Vero, HeLa) regardless of the chlamydial strain (C. pecorum, C. trachomatis serovar E) as shown by indirect immunofluorescence and titration by subpassage. Moreover, a single exposure to wIRA/VIS at 40 hours post infection (hpi) led to a significant reduction of C. pecorum inclusion frequency in Vero cells and C. trachomatis in HeLa cells, respectively. A triple dose of irradiation (24, 36, 40 hpi) during the course of C. trachomatis infection further reduced chlamydial inclusion frequency in HeLa cells without inducing the chlamydial persistence/stress response, as ascertained by electron microscopy. Irradiation of host cells (HeLa, Vero) neither affected cell viability nor induced any molecular markers of cytotoxicity as investigated by Alamar blue assay and Western blot analysis. Chlamydial infection, irradiation, and the combination of both showed a similar release pattern of a subset of pro-inflammatory cytokines (MIF/GIF, Serpin E1, RANTES, IL-6, IL-8) and chemokines (IL-16, IP-10, ENA-78, MIG, MIP-1α/β) from host cells. Initial investigation into the mechanism indicated possible thermal effects on Chlamydia due to irradiation. In summary, we demonstrate a non-chemical reduction of chlamydial infection using the combination of water-filtered infrared A and visible light.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Water-Filtered Infrared A Irradiation in Combination with Visible Light Inhibits Acute Chlamydial Infection

et al. 2014

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“…Several mechanisms of action have been proposed for the anti-inflammatory efficacy of antibiotics and traditional Chinese medicines (TCMs) on respiratory diseases, including COPD, house dust mite-induced allergic asthma, resistance of Klebsiella pneumoniae, and ventilator-associated pneumonia (12)(13)(14)(15). However, the efficacy of such antibiotics was limited by their side effects in clinical trials, which included vomiting, diarrhea, weight loss and headaches (16)(17)(18). At present, no effective control measures have been developed for the treatment of PM 2.5 -induced respiratory diseases apart from reducing PM 2.5 emissions, wearing a dust respirator and increasing the number of plants.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice

Zhang

Sun

et al. 2017

Exp Ther Med

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Abstract. Particulate matter 2.5 (PM 2.5 ) is a growing concern worldwide due to its association with respiratory diseases, including chronic obstructive pulmonary disease (COPD). Stemonine, a traditional Chinese herb, has been demonstrated to exhibit anti-inflammatory and antioxidant properties, making it a potential drug for the treatment of respiratory diseases. The therapeutic effects of stemonine on mice with PM 2.5 -induced COPD were investigated in the present study. Kunming mice were randomly divided into the following five groups (n=10/group): Control, model, low-dose stemonine, moderate-dose stemonine and high-dose stemonine. The model mice received an intranasal instillation of PM 2.5 suspension (40 mg/kg). The levels of specific enzymes, markers of oxidative stress, and the inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 were measured in the bronchoalveolar lavage fluid of the mice using ELISA kits. Hematoxylin and eosin staining was performed to determine inflammatory changes to the lung tissue. It was demonstrated that stemonine could significantly alleviate lung injury by decreasing the levels of enzymes and cytokines associated with inflammation and oxidative stress in a dose-dependent manner. In addition, stemonine dose-dependently increased the amount of superoxide dismutase. These results suggest that stemonine reduces lung inflammation in mice with PM 2.5 -induced COPD, providing a novel approach for the treatment of PM 2.5 -induced respiratory diseases.

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“…The currently used antibiotics and traditional Chinese medicines (TCMs) are believed to inhibit respiratory diseases, including COPD through anti‐inflammatory mechanism . However, the presently available antibiotics have limitation of inducing side effects like weight loss, vomiting, diarrhea, and headaches . There is urgent need for the development of effective treatment strategies for PM2.5‐induced respiratory diseases because the emission of PM is increasing day‐by‐day.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18] However, the presently available antibiotics have limitation of inducing side effects like weight loss, vomiting, diarrhea, and headaches. [19][20][21] There is urgent need for the development of effective treatment strategies for PM2.5-induced respiratory diseases because the emission of PM is increasing day-by-day. The controlling measures like PM2.5 emission reduction, the use of dust respirator, and planting more and more trees alone cannot solve the problem.…”

Section: Introductionmentioning

confidence: 99%

Preventive effect of ursolic acid derivative on particulate matter 2.5‐induced chronic obstructive pulmonary disease involves suppression of lung inflammation

Li¹,

Chen

Yuan³

et al. 2019

IUBMB Life

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Respiratory diseases like chronic obstructive pulmonary disease (COPD) are associated with the presence of particulate matter 2.5 (PM2.5) in the air. In the present study, the effect of synthesized ursolic acid derivatives on mice model of PM2.5‐induced COPD was investigated in vivo. The mice model of COPD was established by the administration of 25 μL of PM2.5 suspension through intranasal route daily for 1 week. The levels of oxidative stress markers and inflammatory cytokines like tumor necrosis factors‐α and interleukin‐6 in the mice bronchoalveolar fluids increased markedly on administration with PM2.5. However, treatment with ursolic acid derivative caused a significant suppression in PM2.5‐induced increase in oxidative stress markers and inflammatory cytokines in dose‐dependent manner. Hematoxylin and eosin staining showed excessive inflammatory cell infiltration in pulmonary tissues in mice with COPD. The inflammatory cell infiltration was inhibited on treatment of the mice with ursolic acid derivative. The ursolic acid derivative treatment increased level of superoxide dismutase in mice with COPD. The lung injury induced by PM2.5 in mice was also prevented on treatment with ursolic acid derivative. Thus, ursolic acid derivative inhibits pulmonary tissues damage in mice through suppression of inflammatory cytokine and oxidative enzymes. Therefore, ursolic acid derivative can be of therapeutic importance for treatment of PM2.5‐induced COPD.

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Complications of Antibiotic Therapy

Cited by 41 publications

References 45 publications

Water-Filtered Infrared A Irradiation in Combination with Visible Light Inhibits Acute Chlamydial Infection

Water-Filtered Infrared A Irradiation in Combination with Visible Light Inhibits Acute Chlamydial Infection

Therapeutic effects of stemonine on particulate matter 2.5‑induced chronic obstructive pulmonary disease in mice

Preventive effect of ursolic acid derivative on particulate matter 2.5‐induced chronic obstructive pulmonary disease involves suppression of lung inflammation

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