Complications encountered in ultrasonography-guided radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers

Kim, Cherry; Lee, Jeong Hyun; Choi, Young Jun; Kim, Won; Sung, Tae Yon; Baek, Jung Hwan

doi:10.1007/s00330-016-4690-y

Cited by 125 publications

(166 citation statements)

References 31 publications

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“…The patients recovered within 2 months. The incidence of recurrent laryngeal nerve palsy was a little higher than that of some previous reports [5,20,[23][24][25]. However, iatrogenic nerve injury cannot be avoid completely even in surgery.…”

Section: Discussionmentioning

confidence: 70%

US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules

Gong

Zhou

et al. 2017

Endocr J

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Section: Discussionmentioning

confidence: 70%

US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules

Gong

Zhou

et al. 2017

Endocr J

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“…[39] The permitted maximal dose of lidocaine is 4.5 mg/kg, up to a total of 300 mg (15 ml). The symptoms of lidocaine toxicity include mental changes, muscle twitching, tremors, and seizures.…”

Section: Resultsmentioning

confidence: 99%

Complications Following Radiofrequency Ablation of Benign Thyroid Nodules

Wang

et al. 2017

Chinese Medical Journal

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Objective:This systematic review examined whether radiofrequency ablation (RFA) is a safe treatment modality for benign thyroid nodules (BTNs).Data Sources:PubMed, Embase, and the Cochrane Library database were searched for articles that (a) targeted human beings and (b) had a study population with BTNs that were confirmed by fine-needle aspiration cytology and/or core needle biopsy.Study Selection:Thirty-two studies relating to 3409 patients were included in this systematic review.Results:Based on literatures, no deaths were associated with the procedure, serious complications were rare, and RFA appears to be a safe and well-tolerated treatment modality. However, a broad spectrum of complications offers insights into some undesirable complications, such as track needle seeding and Horner syndrome.Conclusions:RFA appears to be a safe and well-tolerated treatment modality for BTNs. More research is needed to characterize the complications of RFA for thyroid nodules.

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“…The minor complication rate in the present study was close to those that occurred in the previously published studies including RFA 7 and LA 27 . Sympathetic nerve injury resulting in Horner syndrome, which clinically presents as a combination of ptosis, miosis, and anhidrosis of the face at the ipsilateral side of the injury nerve, is a very rare complication of RFA or MWA in treating BTNs 23 . The possible reason of this complication is the middle cervical sympathetic ganglion usually located at the lower pole of the thyroid was damaged during thermal ablation 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Sympathetic nerve injury resulting in Horner syndrome, which clinically presents as a combination of ptosis, miosis, and anhidrosis of the face at the ipsilateral side of the injury nerve, is a very rare complication of RFA or MWA in treating BTNs 23 . The possible reason of this complication is the middle cervical sympathetic ganglion usually located at the lower pole of the thyroid was damaged during thermal ablation 23 . To minimize the complication, firstly, careful US examination of the adjacent structures around the target nodule plays an important role to distinguish the middle cervical sympathetic ganglion 28 .…”

Section: Discussionmentioning

confidence: 99%

US-guided percutaneous radiofrequency versus microwave ablation for benign thyroid nodules: A prospective multicenter study.

Cheng

2017

JCO

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Compared with microwave ablation (MWA), percutaneous radiofrequency ablation (RFA) and laser ablation (LA) have been recommended as minimally invasive treatments for patients with symptomatic benign thyroid nodules (BTNs) because of the large number of clinical applications. This prospective multicenter study sought to evaluate the clinical outcomes of RFA and MWA for BTNs. In eight participating institutions, the total number of 1252 patients treated by RFA and MWA were 649 ones with 687 BTNs and 603 ones with 664 BTNs, respectively. The clinical outcomes including the nodular maximal diameter reduction ratio (MDRR), the nodular volume reduction ratio (VRR), and the incidence of complications were compared to evaluate the efficacy and safety of the two techniques. The results for the nodular MDRR and VRR in the RFA group were significantly better than those in the MWA group at 6 months and later follow-up, and the major complication rates of 4.78% and 6.63% in RFA and MWA groups showed no statistically significant differences. In conclusion, both RFA and MWA are safe and effective techniques for selected patients with symptomatic BTNs. The achieved MDRR and VRR in the RFA group were greater than those in the MWA group at 6 months and later follow-up.The thyroid nodule is one of the most common lesions in clinical practice 1 and has been increasingly detected in approximately 50% of the general population by ultrasound (US) examination 2 in the past two decades due to the widespread use of radiological imaging. Benign thyroid nodules (BTNs) proven cytologically by fine-needle aspiration biopsy (FNAB) account for 85 to 95% of all thyroid nodules 3 . It is unnecessary to treat most BTNs because of their lack of symptoms and slow growth 4 . Therapy is mainly focused on patients with progressive nodular growth or cosmetic problems and symptoms, which are related to nodular volume 5 . Therefore, it is essential for the treatment of BTNs to maximize the nodular volume reduction ratio (VRR) and minimize complications because of the anatomical features of the thyroid and its adjacent important structures.After over a decade of clinical application, percutaneous radiofrequency ablation (RFA) and laser ablation (LA) under US guidance have become minimally invasive treatments for patients with BTNs, especially for nonsurgical candidates, surgical high-risk individuals or those refusing surgery 5,6 . Low complication rates and high nodular VRRs for RFA and LA have been confirmed in the treatment of BTNs [7][8][9] , and the preservation of thyroid

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Complications encountered in ultrasonography-guided radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers

Cited by 125 publications

References 31 publications

US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules

US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules

Complications Following Radiofrequency Ablation of Benign Thyroid Nodules

US-guided percutaneous radiofrequency versus microwave ablation for benign thyroid nodules: A prospective multicenter study.

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