US-guided percutaneous radiofrequency versus microwave ablation for benign thyroid nodules: A prospective multicenter study.

Cheng, Zhigang

doi:10.1200/jco.2017.35.15_suppl.e17593

Cited by 14 publications

(24 citation statements)

References 16 publications

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“…Although complete ablation could be achieved in all patients because the large sizes of the nodules, the volumes of nodules were reduced, and the patients' symptoms were relieved significantly at the 3-month follow-up. The 3-month VRR of the nodules was 66.7% AE 7.1%, which was close to the results from the latest studies 16,17,23 focusing on MWA for benign thyroid nodules. However, the initial nodule volumes in those studies were less than 15 mL.…”

Section: Discussionsupporting

confidence: 87%

“…In view of the paucity of clinical research on thermal ablation for SSG, we conducted this prospective study. On the base of our previous experience with MWA for thyroid nodules, 23,25 we conducted this study with rigid inclusion criteria, elaborately planned the treatment protocol, and preliminarily explored the feasibility and safety of MWA in treating SSG.…”

Section: Discussionmentioning

confidence: 99%

“…Then the applicator tip was moved to a more superficial section, and the moving procedure was repeated until the hyperechoic area completely encompassed the entire nodule. Power output of 20 to 40 W was applied in MWA . Routinely, 20 and 30 W were applied.…”

Section: Methodsmentioning

confidence: 99%

“…Power output of 20 to 40 W was applied in MWA. 23 Routinely, 20 and 30 W were applied. For the region with rich vascularity, the antenna was moved more slowly, and high-output power (30 W) was applied.…”

Section: Methodsmentioning

confidence: 99%

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Ultrasound‐Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience

Cui

Han

et al. 2019

J of Ultrasound Medicine

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Objectives To preliminarily evaluate the safety, effectiveness, and feasibility of microwave ablation (MWA) for substernal goiter (SSG) in select patients and to provide a relevant treatment reference for further studies. Methods From April 2017 to December 2017, 10 patients with SSG were treated by MWA. All patients were followed for at least 3 months to observe the therapeutic effects and complications. Therapeutic effects were assessed at follow‐up for the relief of patients’ symptoms, resolution of the cosmetic grade, and volume reduction rate (VRR) of SSG. Possibly related factors for the 3‐month VRR of the nodules were analyzed. Results The study included 9 female patients and 1 male patient with a mean age ± SD of 56.8 ± 10.1 years (range, 34–70 years). The mean volume of the nodules was 52.9 ± 27.9 mL (range, 23.7–122.6 mL). The nodule volume was significantly reduced at the 3‐month follow‐up (17.5 ± 9.5 mL; P < .05). The mean 3‐month VRR of the index nodule was 66.7% ± 7.1%. A higher ablated portion‐to‐nodule ratio 1 day after MWA predicted a higher 3‐month VRR (Spearman r = 0.646; P = .044). The mean symptom score (from 4.5 ± 1.7 to 1.5 ± 1.0; P = .005) and cosmetic grade (from 3.3 ± 0.5 to 2.2 ± 0.4; P = .004) declined significantly 3 months after the procedure. No complications or unexpected side effects were observed. Conclusions Our preliminary results support the effectiveness and safety of MWA for local control of SSG. This technology can be applied in select patients with SSG who are ineligible for surgery.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Ultrasound‐Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience

Cui

Han

et al. 2019

J of Ultrasound Medicine

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“…The body of evidence on the use of MWA is smaller than that for LA and RFA. However, the published retrospective trials, meta-analyses and multicentre prospective studies demonstrated encouraging results (12-month volume reduction ratio of 75-90%), although the treated nodules were usually small (< 10 mL) [13,40,41].…”

Section: Solid Nodulesmentioning

confidence: 99%

European Thyroid Association Survey on Use of Minimally Invasive Techniques for Thyroid Nodules

Hegedűs¹,

Frasoldati²,

Negro³

et al. 2020

Eur Thyroid J

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Objective: Image-guided interventional ultrasound (US) techniques represent diagnostic and therapeutic tools for non-surgical management of thyroid nodular disease. We sought to investigate the attitude of European Thyroid Association (ETA) members towards the use of minimally invasive techniques (MIT) in diagnosis/therapy of symptomatic nodular goitre. Methods: ETA members were invited to participate in an online survey investigating the use of MIT in benign and malignant thyroid nodular disease. Of 865 invited members, 221 (25.5%) completed the survey. The respondents were from 40 countries; 139 (74.7%) were from European countries. Results: Respondents personally performed thyroid US (91.6%), Fine needle aspiration (FNA; 75.3%), ethanol ablation (EA; 22.1%), core needle biopsy (CNB; 11%) and thermal treatments (4.8%). When skills and/or technology were unavailable, only 13.4% referred patients "often" or "always" to other centres with specific expertise in this field. Surgery was the preferred first option in patients with recurrent cysts, 4.0 cm benign nodules, local (radioiodine-avid or non-avid) lymph node metastases, or papillary cancers < 1.0 cm. For autonomously functioning nodules radioactive iodine treatment was the preferred choice, followed by surgery. Thermal ablation (TA) was the preferred option only for a 4 cm benign nodule in old patients with comorbidities. Conclusions: US, US-guided FNA and surgery were available to nearly all respondents, while MIT was not. CNB and EA were employed only by about 1/3 of the respondents and TA procedures were available and personally performed only by a minority. For most thyroid lesions, surgery was the preferred option versus thermal therapies. The ETA needs to develop guidelines and establish teaching to overcome geographic inequality and promote the use of MIT as a valid therapy option in appropriate cases.

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RFA and benign thyroid nodules: Review of the current literature

Muhammad

Santhanam

Russell

et al. 2021

Laryngoscope Investig Oto

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Benign thyroid nodules (BTNs) are commonly found in the general population. They are usually asymptomatic and their incidence has increased as a result of wide‐spread use of ultrasound. Benign nodules are typically monitored clinically until they increase in size, resulting in compressive symptoms warranting surgery. However, although surgery is generally well‐tolerated and of low‐risk, it is associated with a small risk for several complications including hypothyroidism, nerve injury, hematoma, injury to other structures and wound infection. Recently, newer image‐guided ablation techniques including radiofrequency ablation (RFA) have been introduced. RFA has a similar safety profile when compared to surgery and has shown promising results in challenging surgical candidates. Though several studies have been published in Asian and European countries on the efficacy of RFA, limited data is available on the North American population. The aim of the study is to review the current literature establishing the clinical outcomes and safety of RFA for benign nodules. Level of evidence V.

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US-guided percutaneous radiofrequency versus microwave ablation for benign thyroid nodules: A prospective multicenter study.

Cited by 14 publications

References 16 publications

Ultrasound‐Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience

Ultrasound‐Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience

European Thyroid Association Survey on Use of Minimally Invasive Techniques for Thyroid Nodules

RFA and benign thyroid nodules: Review of the current literature

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