Complications and Surgical Indications in 144 Cases of Nonmetastatic Osteosarcoma of the Extremities Treated With Neoadjuvant Chemotherapy

Ruggieri, Pietro; Cristofaro, R. De; Picci, Piero; Bacci, G.; Biagini, R.E.; Casadei, Raffaella; Ferraro, Angelo Viglianisi; Ferruzzi, A.; Fabbri, Nicola; Cazzola, Alessandro; Campanacci, Mario

doi:10.1097/00003086-199310000-00034

Cited by 37 publications

(29 citation statements)

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“…Other studies also reported no significant difference in psychological outcome [11]. Better functional results after limb-saving surgery using the MSTS functional evaluation system have been reported in several studies [12,13]. The efficiency of gait expressed as net oxygen cost was lower after endoprosthetic replacement compared to after above-the-knee amputation and after rotationplasty compared to after resection arthrodesis or above-the-knee amputation in patients with tumors about the knee joint [14,15].…”

Section: Discussionmentioning

confidence: 93%

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Function and complications after ablative and limb-salvage therapy in lower extremity sarcoma of bone

et al. 2000

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Section: Discussionmentioning

confidence: 93%

“…Two studies reported an average function of 77% and 80%, respectively [10,26]. In 1 study, functional outcome after rotationplasty was between 50% and 75% in 7/7 patients [12]. One study reported an average function of 63% after above-the-knee amputations [10].…”

Section: Discussionmentioning

confidence: 99%

Function and complications after ablative and limb-salvage therapy in lower extremity sarcoma of bone

et al. 2000

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“…Regarding the first question, survival and local recurrence rates between amputation and limb-sparing surgery have not been found to be significantly different when adequate margins are achieved and adjuvant chemotherapy is used (Simon et al, 1986;Sluga et al, 1999;Bacci et al, 2000;Bielack et al, 2002). When considering short-and long-term complications, several studies have shown that there are more complications following limb-sparing surgery (Ruggieri et al, 1993;Rougraff et al, 1994;Lindner et al, 1999;Nagarajan et al, 2002). Of note, with new techniques and materials being developed for limb-sparig surgeries, long-term outcomes need to be continually evaluated.…”

Section: Discussionmentioning

confidence: 99%

Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing's sarcoma: the Childhood Cancer Survivor Study

et al. 2004

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Limb-sparing surgeries have been performed more frequently than amputation based on the belief that limb-sparing surgeries provide improved function and quality-of-life (QOL). However, this has not been extensively studied in the paediatric population, which has unique characteristics that have implications for function and QOL. Using the Childhood Cancer Survivor Study, 528 adult long-term survivors of pediatric lower extremity bone tumours, diagnosed between 1970 and 1986, were contacted and completed questionnaries assessing function and QOL. Survivors were an average of 21 years from diagnosis with an average age of 35 years. Overall they reported excellent function and QOL. Compared to those who had a limb-sparing procedure, amputees were not more likely to have lower function and QOL scores and self-perception of disability included general health status, lower educational attainment, older age and female gender. Findings from this study suggest that, over time, amputees do as well as those who underwent limb-sparing surgeries between 1970 and 1986. However, female gender, lower educational attainment and older current age appear to influence function, QOL and disability.

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“…Improved function and quality of life have been attributed to limb salvage but have not been universally demonstrated in the adult population [33]. A number of studies document better physical function in patients with limb salvage compared to patients with amputation [1,10,15,22,24,32,38,39]. Other studies have reported no difference in function with limb salvage [4,21,23], but a higher quality of life with limb salvage [37].…”

Section: Introductionmentioning

confidence: 99%

What is the Emotional Acceptance After Limb Salvage with an Expandable Prosthesis?

Henderson¹,

Pepper

Marulanda

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Background Limb preservation surgery for extremity sarcomas offers the promise of improved function and cosmesis over amputation. Application of limb salvage surgery for pediatric patients with expandable metallic endoprostheses is gaining acceptance. The few studies reporting these devices have focused on functional outcomes; one has addressed quality of life. Questions/purposes We asked the following questions: (1) how happy are these patients; (2) how do these patients perceive their bodies; (3) do these children have difficulty with social interactions; and (4) how satisfied are patients and their parents with their outcomes?

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Complications and Surgical Indications in 144 Cases of Nonmetastatic Osteosarcoma of the Extremities Treated With Neoadjuvant Chemotherapy

Cited by 37 publications

References 0 publications

Function and complications after ablative and limb-salvage therapy in lower extremity sarcoma of bone

Function and complications after ablative and limb-salvage therapy in lower extremity sarcoma of bone

Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing's sarcoma: the Childhood Cancer Survivor Study

What is the Emotional Acceptance After Limb Salvage with an Expandable Prosthesis?

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