Complications and outcomes of 890 living liver donor hepatectomies at a single center: risks of saving loved one’s life

Yankol, Yücel; Mecit, Nesimi; Kanmaz, Turan; Kalayoğlu, Münci

doi:10.5578/turkjsurg.4548

Cited by 9 publications

(20 citation statements)

References 45 publications

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“…Second critical outcome was the recovery of liver function (bilirubin and PT/INR peak or value), 9 20 , 23 , 24 , 33 , 44 , 52 , 68 , 71 , 72 , 73 comparative studies and 2 25 , 58 non‐comparative studies were included in the GRADE. The effect from comparative studies was lower with few events.…”

Section: Resultsmentioning

confidence: 99%

When is it safe for the liver donor to be discharged home and prevent unnecessary re‐hospitalizations? – A systematic review of the literature and expert panel recommendations

Mazzola

Pittau

Hong

et al. 2022

Clinical Transplantation

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Background: Few data are available on discharge criteria after living liver donation (LLD).Objectives: To identify the features for fit for discharge checklist after LLD to prevent unnecessary re-hospitalizations and to provide international expert recommendations.Data sources: Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.Methods: Systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. The critical outcomes included were complications rates and liver function (defined by elevated bilirubin and INR) (CRD42021260725).Results: Total 57/1710 studies were included in qualitative analysis and 28/57 on the final analysis. No randomized controlled trials were identified. The complications rate was reported in 20/28 studies and ranged from 7.8% to 71.2%. Post hepatectomy liver

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Section: Resultsmentioning

confidence: 99%

When is it safe for the liver donor to be discharged home and prevent unnecessary re‐hospitalizations? – A systematic review of the literature and expert panel recommendations

Mazzola

Pittau

Hong

et al. 2022

Clinical Transplantation

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“…Of the 939 donors, in 890 donors' followed-up at least 1-year overall early and late complication rate was 19.5%, including 2.9% life-threatening and nearly life-threatening complications. Right donors hepatectomy complication rate (23.3%) was higher than left donor (14.3%) and left lateral sector donor hepatectomy (11.5%) (7). In addition, long-term medical and psychosocial outcomes in living liver donors is always one of the hot topics in the field.…”

Section: Discussionmentioning

confidence: 99%

“…Living liver donor (7) and living kidney donor (8) selection criteria, donor evaluation, surgical techniques and post-operative follow-up plans have been described separately in our previous publications. Donors were both approved by multidisciplinary living liver donor and living kidney donor institutional donor committees.…”

Section: Methodsmentioning

confidence: 99%

Extreme living donation: A single center simultaneous and sequential living liver-kidney donor experience with long-term outcomes under literature review

et al. 2021

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Objective: Living liver and kidney donor surgeries are major surgical procedures applied to healthy people with mortality and morbidity risks not providing any direct therapeutic advantage to the donor. In this study, we aimed to share our simultaneous and sequential living liver-kidney donor experience under literature review in this worldwide rare practice. Material and Methods: Between January 2007 and February 2018, a total of 1109 living donor nephrectomies and 867 living liver donor hepatectomies were performed with no mortality to living-related donors. Eight donors who were simultaneous or sequential living liver-kidney donors in this time period were retrospectively reviewed and presented with their minimum 2- year follow-up. Results: Of the 8 donors, 3 of them were simultaneous and 5 of them were sequential liver-kidney donation. All of them were close relatives. Mean age was 39 (26-61) years and mean BMI was 25.7 (17.7-40). In 3 donors, right lobe, in 4 donors, left lateral sector, and in 1 donor, left lobe hepatectomy were performed. Median hospital stay was 9 (7-13) days. Two donors experienced early and late postoperative complications (Grade 3b and Grade 1). No mortality and no other long-term complication occurred. Conclusion: Expansion of the donor pool by utilizing grafts from living donors is a globally-accepted proposition since it provides safety and successful outcomes. Simultaneous or sequential liver and kidney donation from the same donor seems to be a reasonable option for combined liver-kidney transplant recipients in special circumstances with acceptable outcomes.

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“…Majority of the literature states that surgeon and center experience is closely related with lower complication rates [2][3][4][5]. Kim et al reported that the experience of the center was important in order to decrease the complications rates of donor hepatectomy with their series of over 500 donors [3].…”

Section: Discussionmentioning

confidence: 99%

“…Shaji Matthew et al reported 1 mortality due to biliary sepsis [6]. There are other series reporting biliary and overall complications after donor hepatectomy [2][3][4][5][6][7][8][9][10]. A recent systematic review by Braun et al they reviewed 33 studies, reporting outcomes from 12,653 donors (right lobe: 8231, left lobe: 4422) [2].…”

Section: Discussionmentioning

confidence: 99%

Canlı Vericili Karaciğer Naklinde Retrospektif Donör Hepatektomi Sonuçları- Tek Merkez Deneyimi

Donmez

Andaçoğlu

2021

Archives of Clinical and Experimental Medicine

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Objectives: We aimed to describe our technique and donor selection for donor hepatectomy, review our case series and report our complication rates and outcomes. Materials and Methods: We retrospectively reviewed 41 consecutive donor hepatectomy cases between October 2019 and November 2020 at Yeditepe University, Istanbul, Turkey. Complications were graded according to Clavien-Dindo classification. All cases were performed via laparotomy. Results: Out of 41 donor cases, 38 (92.6%) were right lobe, 2 (4.8%) were left lobe and 1 (2.4%) was left lateral segment donor hepatectomy. Follow up was 9 ±2,2 months (4-16 months). There were 8 (19.5%) complications and all were minor (grade 1 or 2). There were no grade 3 or higher complications. Three (7.3%) of our donors are heterozygous for Factor Leiden mutation and 4 (9.7%) of our donors had heterozygous prothrombin mutation. Length of stay was average 6.4±1.4 days (range=5-12). Ten donors lost weight with a supervised diet and exercise program. There was one wound complication in this subset of patients. Conclusions: We present our single center donor hepatectomy series with excellent results. We also describe successful weight loss for donors with Body Mass Index >30 kg/m 2 . Donor safety is the most important component of living donor liver transplantation. As donor results continue to improve, living donor liver transplant will continue expand worldwide.

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Complications and outcomes of 890 living liver donor hepatectomies at a single center: risks of saving loved one’s life

Cited by 9 publications

References 45 publications

When is it safe for the liver donor to be discharged home and prevent unnecessary re‐hospitalizations? – A systematic review of the literature and expert panel recommendations

When is it safe for the liver donor to be discharged home and prevent unnecessary re‐hospitalizations? – A systematic review of the literature and expert panel recommendations

Extreme living donation: A single center simultaneous and sequential living liver-kidney donor experience with long-term outcomes under literature review

Canlı Vericili Karaciğer Naklinde Retrospektif Donör Hepatektomi Sonuçları- Tek Merkez Deneyimi

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