Canlı Vericili Karaciğer Naklinde Retrospektif Donör Hepatektomi  Sonuçları- Tek Merkez Deneyimi

Donmez, Ramazan; Andaçoğlu, Oya

doi:10.25000/acem.929684

Cited by 2 publications

(2 citation statements)

References 19 publications

(33 reference statements)

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“…Minimizing the rates of complications related to surgery and ensuring post-operative quality of life in people undergoing donor hepatectomy are crucial for the safety and social incentive dimension of this surgery [ 1 , 2 ]. Therefore, thorough donor preparation is vital to reduce complications.…”

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confidence: 99%

Factor 5 and Factor 2 heterozygous positivity and complications in living donor liver transplant donors

Anilir

2023

North Clin Istanbul

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OBJECTIVE Factor 2 and Factor 5 mutations are among the most common procoagulant genetic disorders and are routinely evaluated in donor preparation. Homozygous mutations are contraindicated for surgery, but heterozygous mutations cannot be said to be an impediment. We aimed to investigate the effect of heterozygous gene mutation of F2 and/or F5 on complications. METHODS In our study, 210 living liver donors were examined. The available data of Factor 2 and 5 heterozygous positive donors were evaluated in terms of 21 donor patients and 30 liver recipients. The heterozygous positive group and the control group were statistically compared in terms of age, gender, length of hospital stay, post-operative deep vein thrombosis, pulmonary embolism, portal vein thrombosis, bile duct stenosis and bile leakage complications, lung infection and atelectasis, and wound infection. In addition, these patients were statistically compared in terms of laboratory tests. In addition, complications in recipients implanted with mutant grafts were evaluated statistically and numerically. RESULTS Hospital staying was longer statistically in the donor group with heterozygous mutations than in the control group. Hemoglobin and albumin blood levels were lower (p=0.031, p=0.016); INR and ALT levels were higher (p=0.005, p=0.047) statistically in the control group than in the donor group with heterozygous mutations. There was no statistically significant difference between heterozygous mutant groups in terms of biliary tract complications and hepatic vessel thrombosis in recipients. CONCLUSION Considering the longer hospital stay in the presence of these mutations, the increased need for treatment in this process and the close follow-up of liver functions should be considered.

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confidence: 99%

Factor 5 and Factor 2 heterozygous positivity and complications in living donor liver transplant donors

Anilir

2023

North Clin Istanbul

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“…Initial studies reported living liver donor complications of up to 50%, but over the decades, living liver donor complications have been reported at around 10-15% [9]. Biliary complications are considered the most common morbidity experienced by living liver donors and can occur in up to 9% of living liver donors [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

An Elbow Patch Reconstruction Technique for Narrowed Remnant Portal Veins during Right Lobe Living Donor Hepatectomy: A Rescue Surgery

Usta,

Akbulut,

Sarici

et al. 2024

JCM

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Background: Treatment of established portal vein narrowing after living donor hepatectomy is challenging. We aimed to present a new approach termed the “elbow patch reconstruction technique” to correct the narrowed remnant portal vein just or late after right lobe living donor hepatectomy. Methods: Demographic and clinical data of 12 living liver donors with narrowed remnant portal veins and treated with the “elbow patch reconstruction technique” were prospectively collected and retrospectively evaluated. Anatomic variation of the portal vein was defined in accordance with the Nakamura classification; six of the living liver donors had type A, three had type B, and the remaining three had type C. In eight of the living liver donors with a narrowed remnant portal vein, diagnosis was detected by intraoperative Doppler ultrasonography and visual inspection by experienced transplant surgeons in the living donor hepatectomy procedure. In the remaining four living liver donors, diagnosis was performed postoperatively when elevation of liver enzymes was noticed during the routine liver function test and Doppler US. The diagnosis was confirmed by multidetector computed tomography. Results: Data from nine males and three females aged 18 to 54 years were analyzed. All of the living liver donors were followed up for a median of 1710 days (min-max: 1178–4447 days; IQR: 1516 days), and none of the living liver donors had any structural or functional complications in the portal vein. Conclusions: Narrowing remnant portal veins are rare, but they are a life-threatening complication in living liver donors, and this condition requires urgent management. Image guided interventions and narrowed segment resection with end-to-end anastomosis using a vascular graft carried a potential risk for thrombosis and restenosis. To avoid these complications, we shared a technique named “elbow patch reconstruction technique”. This technique can be very effective in relieving the narrowing of the remnant portal vein after right lobe living donor hepatectomy.

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Canlı Vericili Karaciğer Naklinde Retrospektif Donör Hepatektomi Sonuçları- Tek Merkez Deneyimi

Cited by 2 publications

References 19 publications

Factor 5 and Factor 2 heterozygous positivity and complications in living donor liver transplant donors

Factor 5 and Factor 2 heterozygous positivity and complications in living donor liver transplant donors

An Elbow Patch Reconstruction Technique for Narrowed Remnant Portal Veins during Right Lobe Living Donor Hepatectomy: A Rescue Surgery

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