Complications after polymethylmethacrylate (<scp>PMMA</scp>) injections in the face: a literature review

Medeiros, Clarissa Castro Galvão; Cherubini, Karen; Salum, Fernanda Gonçalves; Figueiredo, Maria Antonia Zancanaro de

doi:10.1111/ger.12044

Cited by 21 publications

(28 citation statements)

References 71 publications

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“…These results were similar to those reported in previous studies, wherein giant cells were always present at the implantation sites [7,11,12,28,29].…”

Section: Discussionsupporting

confidence: 92%

“…The PMMA microspheres used in this study exhibited ideal characteristics in terms of inertness, stability at room temperature, availability, low production cost, physical consistency at the implantation site similar to that of un implanted tissue, and durability [7][8][9][10][11][12]18,19,28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Because of its small number of side effects and its lasting results, PMMA is believed to be a good solution for dermal filling. However, with the popularization of its use reports of complications following PMMA implantation have increased significantly [20][21][22][23][24][25][26][27][28][29]. Therefore, understanding the tissue alterations caused by PMMA implantation is essential for discover the causes of complications inherent to this filling procedure.…”

Section: Introductionmentioning

confidence: 99%

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Potential of Migration and Tissue Reactions to Intraperitoneally Implanted Polymethyl Methacrylate in Wistar Rats

Fc¹,

Acl²,

A³

2016

J Clin Exp Dermatol Res

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Objective: This study aimed to evaluate the performance of polymethyl methacrylate (PMMA) when implanted into the peritoneal cavities of Wistar rats, specifically its potential for migration to the examined organs and possible tissue reactions at the implantation site.Methods: Adult male Wistar rats (290-400 g) were distributed randomly into 2 groups: P4 (n=20), to which 0.4 mL of PMMA was administered; and P2 (n= 0), to which was 2 mL of PMMA were administered. These groups were subsequently divided into 4 subgroups according to the day on which euthanasia occurred (day 1, 7, 14, or 28). Results:The changes in animal weight prior to PMMA implantation and after euthanasia were compared. No nodules or signs of PMMA implantation or any other macroscopic alterations were observed in the spleen, kidneys, lungs, or liver. However, mild-to-moderate inflammatory infiltration in which macrophages, lymphocytes, and neutrophils predominated was observed in at least 1 of the 4 organs examined from each animal during the experimental time points. Mild inflammatory responses were observed that were rich in histiocytes and giant cells and featured increased numbers of blood vessels and fibroblasts in the pericapsular regions of the studied organs. In 29 cases, a greyish material compatible with PMMA was identified. There was no migration of PMMA into the parenchyma of the examined organs. The changes in the tissues were the same regardless of the volume of implanted PMMA. Following staining with HE, the PMMA particles in the tissues were a grayish color, measuring approximately 30-40 µm in size, and were found to have stimulated histiocytic reactions in 29 examined organs. Conclusions:The results showed that the most affected tissues were the visceral peritoneum of the spleen and the kidneys from group P2. Our study may contribute to add a new proof of testing implants.

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“…These results were similar to those reported in previous studies, wherein giant cells were always present at the implantation sites [7,11,12,28,29].…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential of Migration and Tissue Reactions to Intraperitoneally Implanted Polymethyl Methacrylate in Wistar Rats

Fc¹,

Acl²,

A³

2016

J Clin Exp Dermatol Res

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“…A series of publications on the advantages and disadvantages of PMMA fillers has been published recently, [8][9][10][11][12][13] and their possible complications have been mentioned in detail [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] and reported to the FDA. Most of the published and presented granulomas have been caused by the impure Brazilian PMMA and Artecoll injected before 2006.…”

Section: Complications After Injecting Polymethylmethacrylate Fillersmentioning

confidence: 99%

Prevention and Treatment of Complications after Polymethylmethacrylate-Microspheres Injections

Vent

Lemperle

2014

Facial plast Surg

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“…Complications associated with temporary fillers usually occur immediately after the injection and are easily treated, or, alternatively, they resolve spontaneously. Complications with permanent fillers may occur years after implantation and typically require more complex treatment [2]. The classification of dermal filler complications can be divided into early and late and into minor and major events.…”

Section: Introductionmentioning

confidence: 99%

Another face of dermal fillers

Witmanowski

Błochowiak²

2020

pdia

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Potential complications related to dermal fillers depend on the type of the fillers and the site of their application. The classification of dermal filler complications can be divided into early and late, and into minor and major events. According to their mechanism, they can be divided into non-ischaemic and ischaemic complications. The aim of this study is to present possible complications related to dermal fillers, to explain their aetiology and to propose preventive management and treatment. Non-ischaemic complications can be technique-dependent and include the reactions at the site of the injection, contour irregularities, and inflammatory and infectious reactions. They are usually resolved as a matter of course after 2-7 days. Arterial or venous occlusion leads to ischemia, with subsequent necrosis of the skin and/or vision loss.

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Complications after polymethylmethacrylate (PMMA) injections in the face: a literature review

Abstract: Polymethylmethacrylate is widely used because it is inexpensive, readily accessible and simple to apply. However, some complications are severe and permanent and can be confused with other types of stomatological lesions.

Cited by 21 publications

References 71 publications

Potential of Migration and Tissue Reactions to Intraperitoneally Implanted Polymethyl Methacrylate in Wistar Rats

Potential of Migration and Tissue Reactions to Intraperitoneally Implanted Polymethyl Methacrylate in Wistar Rats

Prevention and Treatment of Complications after Polymethylmethacrylate-Microspheres Injections

Another face of dermal fillers

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