Another face of dermal fillers

Abstract

Potential complications related to dermal fillers depend on the type of the fillers and the site of their application. The classification of dermal filler complications can be divided into early and late, and into minor and major events. According to their mechanism, they can be divided into non-ischaemic and ischaemic complications. The aim of this study is to present possible complications related to dermal fillers, to explain their aetiology and to propose preventive management and treatment. Non-ischaemic complications can be technique-dependent and include the reactions at the site of the injection, contour irregularities, and inflammatory and infectious reactions. They are usually resolved as a matter of course after 2-7 days. Arterial or venous occlusion leads to ischemia, with subsequent necrosis of the skin and/or vision loss.

Infections in patients with adverse reactions to the use of unknown modeling substances for soft tissue enhancement in Cali, Colombia

“…In our patients, the average time interval between the injection of modeling substances and the presentation of clinical manifestations was 4 years. Complications with permanent fillers may occur years after implantation [ 22 ], and it has been determined that one of the main manifestations of the injection of filler substances is a chronic local inflammatory reaction accompanied by multiple symptoms and signs, with the onset of symptoms at 4.3–4.5 years [ 2 ].…”

“…may occur years after implantation [22], and it has been determined that one of the main manifestations of the injection of filler substances is a chronic local inflammatory reaction accompanied by multiple symptoms and signs, with the onset of symptoms at 4.3-4.5 years [2].…”

“…It has been established that after cosmetic dermal filler injections, bacteria of low virulence can produce infections several months after the procedure, and these are associated with the formation of biofilms or nonattached aggregated bacterial cells [24]. Because the identification of biofilms is difficult, culture tests are typically negative, and complications are attributed to the immune response to filler substances [22,25]. The inflammatory process may involve an active granuloma years after injection, which may be related to the development of bacterial biofilms or microbial colonies encapsulated in the extracellular matrix surrounding the foreign body, leading to chronic nonsymptomatic infections with gradual reactivation [26][27][28].…”

Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study

“…Facial plastic surgery, for reconstructive and cosmetic reasons, aims to achieve harmony of facial features in case of volume loss, aging or just as an aesthetic tool. Lipofilling promises to establish a custom fit long-term outcome with minor adverse effects as opposed to the more severe adverse effects that temporary fillers such as hyaluronic acid filler may cause [ 7 , 8 ]. Autologous fat grafts offer several benefits, including lack of immunogenicity, simplicity of surgical procedure, low cost, and easy accessibility.…”

Biofilm

“…The matrix surrounds, supports, and provides structure for the biofilm. The cells within the biofilm stick to each other and also adhere to surfaces (Chiaie, 2023; Convery et al, 2021; Dumitraşcu & Georgescu, 2013; Funt & Pavicic, 2013; Hee & Messina, 2018; Heydenrych et al, 2018; Kim et al, 2020; Urdiales-Gálvez et al, 2018; Witmanowski & Blochowiak, 2020). See Figure 1 for a description of the five phases of biofilm development.…”