Complication characteristics between young-onset type 2 versus type 1 diabetes in a UK population

Song, Soon H

doi:10.1136/bmjdrc-2014-000044

Cited by 78 publications

(74 citation statements)

References 32 publications

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“…This result is similar to The National Diabetes Urban Survey (NUDS) conducted in India in 2000 which showed that more than 50% of diabetic cases developed T2DM before the age of 50 years [40]. Since the onset of T2DM is very early compared to other ethnic groups, complications and chronic risks of T2DM are set at an early years, cardiovascular risk [45][46][47], ischemic heart disease and neuropathy [46], other risks related with early onset of T2DM [48], obesity [49], clinical risk factor [50] agreement with many factors [51] etc. and therefore, mortality rate increases due to T2DM.…”

Section: Development Of Early Complicationssupporting

confidence: 72%

Analysis of complicating risk factors of Type 2 Diabetes Mellitus (T2DM)

Raj¹,

Navis²,

Bhatti³

et al. 2018

Integr Obesity Diabetes

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Background: Type 2 diabetes mellitus (T2DM) is a complicated disease affecting different populations and the starting age of subjects is as early as 15 years old. Since anthropometric, clinical and genetic risk factors are associated with the development of T2DM, the complications developed due to T2DM are life-threatening. Therefore, this research analyzes the complicating risk factors of T2DM. Materials and methods:An observational study of approximately 10,000 north Indian individuals were contacted and a total of 703 subjects (351 control subjects and 352 T2DM subjects) belonging to north Indian states were recruited for the analysis of the risk factors.Result: Very early onset of T2DM, very large undiagnosed population, high newly diagnosed T2DM subjects, independent effect of complicating risk factors etc. were the results obtained from the research. Conclusion:Considering the complications and early onset of T2DM, despite the other diseases along with T2DM, early mortality and increased mortality due to T2DM were observed in north Indian population.major role in the susceptibility to T2DM. There are much differences seen in insulin secretion and sensitivity and nonalcoholic fatty liver disease and T2DM in subjects with different risk factors [18]. However, new alcohol drinkers in middle age and drink rarely may experience benefit in cardiovascular disease and diabetic complication [19] whereas rare and light drinkers after increasing alcohol consumption over short period of time are associated with lower risk of T2DM [20]. Moreover, cigarette smoking and smoking cessation lead to higher short-term risk of T2DM [21].The long term complications of T2DM are chronic complications in circulatory system that may cause blindness, lower limb gangrene and renal failure in adults. It is also a major risk factor for strokes and other cardiovascular diseases (CVD) [22]. Since T2DM is common, its related disorders such as nephropathy [23], neuropathy and retinopathy are also more common. Diabetic nephropathy is a serious complication of T2DM and the prevalence of nephropathy has been increasing worldwide [24,25]. In subjects with CAD and T2DM, the complications lead to functional and structural vascular alterations of the peripheral Materials and MethodologyIn this research, a preliminary observation of incidence of T2DM subjects of approximately 10,000 was interviewed. Apart from this, 351 control and 352 T2DM subjects from nearby locations of Chandigarh belonging to the states of Haryana, Utter Pradesh, Himachal Pradesh, Jammu Kashmir, Punjab, Delhi, Rajasthan, West Bengal etc. and resident of Chandigarh, Panchkula, Mohali, Baltana, etc. were recruited. This is because these cities/towns have resident migrated populations of these states. They were recruited at referral points /schools / hospitals etc. to administer the questionnaire for the data capture for this research. The subjects were completely analyzed using the criteria for control and T2DM subjects specified by diabetes associations. A formal broc...

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Section: Development Of Early Complicationssupporting

confidence: 72%

Analysis of complicating risk factors of Type 2 Diabetes Mellitus (T2DM)

Raj¹,

Navis²,

Bhatti³

et al. 2018

Integr Obesity Diabetes

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“…Our results collaborated with the results of Heidari and Rassoulinejad et al who reported dyslipidemia, smoking and hypertension were not associated with DR. 5 Song et al reported increased age, higher prevalence of obesity, hypertension, and dyslipidemia are significantly causing risk factors for diabetic retinopathy. 6 Ocular complications occur at higher BMI levels than other complications in both genders were reported by Gray and Picone et al 7 Obesity imposes diabetic patients to more severe DR due to inflammatory process. Both obesity and inflammation play a role in the development of endothelial impairment involved in diabetic retinopathy.…”

Section: Diabetic Retinopathy (Dr) and Risk Factorsmentioning

confidence: 79%

“…11 Song, reported neuropathy became significantly higher in T2DM after 20 years duration. 6 Distal symmetrical polyneuropathy shows a constant rise with duration reported by Orchard and Dorman et al 12 Ramachandran and Snehalatha et al showed that age and higher HbA1 had a significant association with neuropathy but hypertension was not associated with the complications of neuropathy. …”

Section: Diabetic Neuropathy (Dn)mentioning

confidence: 92%

A study of micro vascular complications and associated risk factors in newly diagnosed patients of type 2 diabetes mellitus

Prakash¹,

Yadav²

2018

Int J Community Med Public Health

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INTRODUCTIONDiabetes mellitus type 2 is the most common non communicable chronic metabolic disorder caused by the relative insufficiency of insulin secretion and insulin action. If it is not properly treated or left untreated it is characterized by chronic hyperglycaemia and disordered carbohydrate, lipid and protein metabolism and is associated with the development of specific microvascular complications and of non-specific macrovascular disease. The global prevalence and economic cost of diabetes and its complications are abnormally increasing and become a real problem of developed and developing countries like India and this is projected to increase substantially over the next 2 decades. According to the diabetes atlas, seventh edition 2015 published by the IDF. The total number of people with diabetes in India currently around 69.2 million is expected to rise to 123.5 million by 2040. 2Diabetes complications can affect many parts of body, manifesting in different ways in different people. Moreover, at least one complication is present in large ABSTRACT Background: Diabetes and its complications are one of the leading causes of death and disability worldwide. The aim of the study is to elucidate the prevalence and associated risk factors of microvascular complication among diabetes mellitus type 2 population of Ajmer, Rajasthan India. Methods: This is the study of 464 newly detected type 2 diabetic people screened for their biochemical parameters, attending outpatient department comprising of 256 male and 208 female. The presence of complications was evaluated by relevant investigations. Results: Microvascular complication namely retinopathy was diagnosed in 344 (74%) of type 2 diabetic patients, neuropathy in 200 (43%), nephropathy in 138 (30%). Linear regression analysis concluded that age, body mass index, duration, family history, stress, glycated haemoglobin (HbA1C), triglyceride and total cholesterol were significantly associated with these vascular complications. Prevalence of microvascular complications increases with age, duration, body mass index (BMI), hereditary and poor glycemic control. Conclusions: Retinopathy and neuropathy were the most prevalent microvascular complication in type 2 diabetic population.

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“…patients with young-onset type 2 diabetes (age of onset ,40 years) (3)(4)(5)(6). However, the natural history of young patients with type 2 diabetes and resulting complications has not been well studied.…”

mentioning

confidence: 99%

Prevalence of Diabetes and Diabetic Nephropathy in a Large U.S. Commercially Insured Pediatric Population, 2002–2013

Jick

Breitenstein

et al. 2015

Diabetes Care

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OBJECTIVE To estimate the prevalence of diabetes and diabetic nephropathy in a large population of U.S. commercially insured patients aged <18 years from 2002 to 2013. RESEARCH DESIGN AND METHODS Using the U.S. MarketScan Commercial Claims and Encounters Database, we identified 96,171 pediatric patients with diabetes and 3,161 pediatric patients with diabetic nephropathy during 2002–2013. We estimated prevalence of pediatric diabetes overall, by diabetes type, age, and sex, and prevalence of pediatric diabetic nephropathy overall, by age, sex, and diabetes type. RESULTS The annual prevalence of diabetes in the whole pediatric population increased from 1.86 to 2.82 per 1,000 during 2002–2013: 1.48 to 2.32 per 1,000 for type 1 diabetes and 0.38 to 0.67 per 1,000 for type 2 diabetes in 2002–2006 and then 0.56 to 0.49 per 1,000 thereafter. The annual prevalence of diabetic nephropathy in pediatric patients with diabetes increased from 1.16 to 3.44% for all cases and 0.83 to 2.32% for probable cases only in 2002–2013. Prevalence of diabetes and diabetic nephropathy was highest in patients aged 12 to <18 years. While prevalence of type 1 diabetes was higher in male than in female youth, prevalence of type 2 diabetes and diabetic nephropathy was higher in female than in male youth. There was no difference in prevalence of diabetic nephropathy by diabetes type. CONCLUSIONS The prevalence of diabetes and diabetic nephropathy increased in the U.S. MarketScan commercially insured pediatric population from 2002 to 2013. The prevalence of diabetes and diabetic nephropathy markedly increased starting at age 12 years.

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Complication characteristics between young-onset type 2 versus type 1 diabetes in a UK population

Cited by 78 publications

References 32 publications

Analysis of complicating risk factors of Type 2 Diabetes Mellitus (T2DM)

Analysis of complicating risk factors of Type 2 Diabetes Mellitus (T2DM)

A study of micro vascular complications and associated risk factors in newly diagnosed patients of type 2 diabetes mellitus

Prevalence of Diabetes and Diabetic Nephropathy in a Large U.S. Commercially Insured Pediatric Population, 2002–2013

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