“…[4][5][6][7][8][9][10] Because of the great economic and functional burden of PCO, several surgical and nonsurgical strategies to prevent PCO have been proposed. These include the use of chemical substances and antibodies [11][12][13] ; hyperthermia 14 ; careful cleanup of the capsular bag 15,16 ; new IOL designs, coatings, and biomaterials [16][17][18][19][20][21][22][23] ; primary posterior continuous curvilinear capsulorhexis (PCCC) [24][25][26][27][28] ; and IOL capture or buttonholing. 29 The diversity of these recently developed therapeutical approaches relies on increased knowledge of the pathophysiology behind PCO, which is generally accepted to comprise 4 classic steps: (1) adhesion, (2) proliferation, (3) migration of the remaining LECs to the capsule, and (4) differentiation to myofibrotic cells.…”