Complicaciones óseas en un paciente con lepra lepromatosa

Lagrán, Z. Martínez de; Arrieta-Egurrola, A.; González‐Pérez, R.; Soloeta-Arechavala, R.

doi:10.1016/s0001-7310(09)71912-x

Cited by 5 publications

(10 citation statements)

References 3 publications

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“…Bone changes are one of the important prognostic factors in leprosy 7 and can be divided into three groups: specific, non-specific, and osteoporotic bone changes. 7 , 8 , 10 The frequency of bone changes has varied from 15% to 29% of leprosy cases. 7 Specific bone changes are caused by direct actions of M. leprae on bone tissues.…”

Section: Discussionmentioning

confidence: 99%

“… 7 , 8 , 10 The frequency of bone changes has varied from 15% to 29% of leprosy cases. 7 Specific bone changes are caused by direct actions of M. leprae on bone tissues. 1 , 7 , 11 Specific bone changes in leprosy are rare variants and the prevalence ranges from 3% to 5%.…”

Section: Discussionmentioning

confidence: 99%

“… 5 In addition, the examination and early treatment of bone and joint complications can reduce disabilities and deformities in leprosy. 1 , 4 , 7 This case report aimed to show a rare finding of abundant Mycobacterium leprae in the synovial fluid of a lepromatous leprosy patients with bone changes and leprosy-related chronic arthritis.…”

Section: Introductionmentioning

confidence: 99%

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Leprosy-Related Chronic Arthritis with an Abundance of Mycobacterium Leprae in the Synovial Fluid: A Rare Case

Gunawan

Wulansari

Achdiat

et al. 2021

IMCRJ

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Bone and joint involvements are the most common manifestation in leprosy, after cutaneous and neurological manifestations, yet are underdiagnosed and rarely reported. We report a case of lepromatous leprosy in a 41-year-old male with bone and joint changes. Physical examination revealed a leonine face, madarosis, hypesthetic hypopigmented macules on the back, and swelling of fingers and toes. Acid-fast bacilli from slit-skin smear and synovial fluid in an interphalangeal joint of the hand were found. Radiographic features showed osteolysis and destruction of some phalanges of the hands, bone erosion and destruction of some phalanges of the feet, as well as destruction and subluxation of some hand joints. The patient was given multidrug therapy for multibacillary leprosy, resulting in the reduction of swelling in fingers and toes. In conclusion, the examination of bone and joint changes in leprosy patients is important for early detection and management of musculoskeletal complications, to prevent future deformities and disabilities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Leprosy-Related Chronic Arthritis with an Abundance of Mycobacterium Leprae in the Synovial Fluid: A Rare Case

Gunawan

Wulansari

Achdiat

et al. 2021

IMCRJ

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“…BSS is a rare entity with more than fifty cases published internationally to date. [ 4 5 6 7 ] It is characterized by the progressive development of adnexal skin tumors in scalp and face. Clinical manifestations start since puberty and its incidence is higher in females without distinction of race.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations start since puberty and its incidence is higher in females without distinction of race. [ 1 4 ] BSS has also been associated with increased risk of salivary glands neoplasms and other tumors although with very little evidence. [ 1 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Heterozygous cylindromatosis gene mutation c.1628_1629delCT in a family with brook-spiegler syndrome

et al. 2016

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Brooke–Spiegler Syndrome (BSS) is a rare genodermatosis characterized by the progressive formation of adnexal skin tumors in the scalp and face, mainly trichoepitheliomas, cylindromas, and spiradenomas. It has also been associated with salivary glands neoplasms. It is due to mutations in the tumor suppressor gene cylindromatosis (CYLD gene) localized on chromosome 16q12−q13. Around 93 mutations have been described. The study of CYLD gene in patients and their relatives is of vital importance to establish the molecular diagnosis and offer appropriate genetic counseling. There is a low risk of malignancy and patients require long-term follow-up. A case of BSS in a family is described. The existence of the genetic mutation at the CYLD gene c. 1628_1629delCT in three of the women affected was demonstrated. This mutation has only been described once in a previous study.

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Lepra: puesta al día. Definición, patogénesis, clasificación, diagnóstico y tratamiento

Eichelmann

González

Salas‐Alanís

et al. 2013

Actas Dermo-Sifiliográficas

124

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Complicaciones óseas en un paciente con lepra lepromatosa

Cited by 5 publications

References 3 publications

Leprosy-Related Chronic Arthritis with an Abundance of Mycobacterium Leprae in the Synovial Fluid: A Rare Case

Leprosy-Related Chronic Arthritis with an Abundance of Mycobacterium Leprae in the Synovial Fluid: A Rare Case

Heterozygous cylindromatosis gene mutation c.1628_1629delCT in a family with brook-spiegler syndrome

Lepra: puesta al día. Definición, patogénesis, clasificación, diagnóstico y tratamiento

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