Ventricular septal rupture (VSR) after myocardial infarction is often complicated by cardiogenic shock (CS) with high in-hospital mortality rates. Early use of preoperative venoarterial extracorporeal membrane oxygenation (VA ECMO) and delayed surgical repair have demonstrated lower mortality rates; however, the optimal timing of surgical intervention remains controversial. We report the case of a 53-year-old man with CS stage D due to post-myocardial infarction VSR, who was successfully treated with VA ECMO as a bridge to delayed surgical repair. This case highlights the complexity of determining the optimal timing for surgical intervention in these patients and emphasizes the benefits of early use of VA ECMO for preoperative stabilization in patients with CS and multiorgan failure.