Compliance with Local Guidelines for Antibiotic Prophylaxis in Surgery

Abstract

Surgeons sensitized to the implementation of local antibiotic prophylaxis guidelines showed a high degree of compliance with them, using both the procedure established for antibiotic prescribing and the antimicrobials recommended for particular operations

Preoperative antibiotic prophylaxis practice and guideline adherence in Jordan: a multi-centre study in Jordanian hospitals

“…It has a relatively long duration of action [7], is effective against the most commonly encountered organisms in surgical procedures, and has a relatively low cost [4,7]. In Jordanian hospitals, the third-generation cephalosporin (ceftriaxone) was most commonly used in the surveyed departments, followed by the secondgeneration (cefuroxime) and for limited cases the firstgeneration cephalosporin (cephalexin).…”

“…In another study performed in Eastern France, among 117 patients who received inappropriate SAP, 95.7% received a broad-spectrum antibiotic regimen [11]. This excessive use of broad-spectrum antibiotics for prophylaxis increases the risk for resistance [2,4,19], causes more adverse events [19], and increases healthcare costs [2,19].…”

“…SSI is also considered among the most expensive nosocomial infections [3]. Prophylactic use of antibiotics can reduce the incidence of SSI [2] by providing an adequate level of the antimicrobial agent in the tissues before surgery [4].…”

“…The risk of surgical site infection also depends on whether the surgery is a clean, clean-contaminated, contaminated or dirty procedure [4]. Surgical antibiotic prophylaxis (SAP) is not only intended to establish bactericidal tissue and serum levels at the time of skin incision, but also to reduce the microbial burden of intraoperative contamination to a level that cannot overcome host defenses [5].…”

Cross–sectional Study of Surgical Prophylactic Antibiotic Administration in Marzoeki Mahdi Hospital, Bogor, Indonesia

“…The emergence of extended spectrum beta-lactamase, vancomycin-resistant enterococci, and Clostridium difficile has also been widely reported to be associated with the inappropriate use of third generation cephalosporin [22]. In general, non-compliance with the guidelines for surgical prophylaxis is due to a lack of awareness of the guidelines, the availability of prophylactic antibiotics, and the belief that broad-spectrum antibiotics to be more effective in preventing SSIs compare with the narrow spectrum antibiotic prophylaxis [23][24][25]. To improve the level of compliance with the guidelines for the use of surgical antibiotic prophylaxis requires collaboration among health professions.…”