Compliance with anti-tuberculosis preventive therapy among 6-year-old children

Alperstein, Garth; Morgan, Keira R.; Mills, Kay; Daniels, Lorraine

doi:10.1111/j.1467-842x.1998.tb01174.x

Cited by 18 publications

(20 citation statements)

References 7 publications

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“…This has been reported elsewhere [12,15]. A South African study found older children were more likely to complete treatment.…”

Section: Discussionsupporting

confidence: 82%

“…Research in TB endemic settings in South Africa found adherence rates for children < 5 years prescribed six months IPT to be between 15-28% [10,11]. In Australia IPT adherence rates among six-year-old children were between 54-74% [15] and in Brazil only 53% of all household contacts completed IPT with 29% being immediately lost to follow-up [16]. …”

Section: Discussionmentioning

confidence: 99%

“…Caregivers of children with good adherence frequently mentioned a desire for health while caregivers of children with poor adherence often expressed a belief that IPT is unnecessary for healthy children. Similarly, in Australia, from interviews with 67 families of children prescribed IPT, only 65% believed their child required therapy [15] while in South Africa reduced risk perception was commonly displayed by parents of non-adherent children [10]. …”

Section: Discussionmentioning

confidence: 99%

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Adherence to isoniazid preventive therapy in Indonesian children: A quantitative and qualitative investigation

et al. 2012

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BackgroundIt is recommended that young child contacts of sputum smear positive tuberculosis cases receive isoniazid preventive therapy (IPT) but reported adherence is low and risk factors for poor adherence in children are largely unknown.MethodsWe prospectively determined rates of IPT adherence in children < 5 yrs in an Indonesian lung clinic. Possible risk factors for poor adherence, defined as ≤3 months prescription collection, were calculated using logistic regression. To further investigate adherence barriers in-depth interviews were conducted with caregivers of children with good and poor adherence.ResultsEighty-two children eligible for IPT were included, 61 (74.4%) of which had poor adherence. High transport costs (OR 3.3, 95% CI 1.1-10.2) and medication costs (OR 20.0, 95% CI 2.7-414.5) were significantly associated with poor adherence in univariate analysis. Access, medication barriers, disease and health service experience and caregiver TB and IPT knowledge and beliefs were found to be important determinants of adherence in qualitative analysis.ConclusionAdherence to IPT in this setting in Indonesia is extremely low and may result from a combination of financial, knowledge, health service and medication related barriers. Successful reduction of childhood TB urgently requires evidence-based interventions that address poor adherence to IPT.

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“…This has been reported elsewhere [12,15]. A South African study found older children were more likely to complete treatment.…”

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adherence to isoniazid preventive therapy in Indonesian children: A quantitative and qualitative investigation

et al. 2012

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“…6,7,[34][35][36][37] In our study, poor staff knowledge of isoniazid preventive therapy and poor compliance with guidelines were found to be barriers to the initiation of therapy. Similar barriers have been reported in other countries: in India, health-care workers reported that unclear guidelines on child contact management inhibited their ability to implement therapy; 38 in Thailand, doctors were reluctant to initiate therapy due to concerns about isoniazid toxicity and resistance; 22 in Australia, doctors actively advised patients not to use isoniazid preventive therapy; 34 in the United States of America, medical graduates did not believe isoniazid preventive therapy was protective against disease progression; 39 and, in Malawi, health-care workers felt that screening child contacts by chest radiography was not worthwhile. 33 As in other countries, we found that primary caregivers' acceptance of the child contact management programme was hindered by barriers such as limited knowledge of isoniazid preventive therapy, difficulty accessing screening and treatment and reluctance to treat asymptomatic children.…”

Section: Discussionmentioning

confidence: 99%

Management of children exposed toMycobacterium tuberculosis: a public health evaluation in West Java, Indonesia

Rutherford

Ruslami

Anselmo

et al. 2013

Bull. World Health Organ.

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“…Nides et al (12) found that patients who received feedback on their medication taking were more adherent than those who did not. Parental monitoring and supervision of children's daily self-monitoring also improves medication adherence (13,14).…”

Section: Children's Use Of Symptom Diariesmentioning

confidence: 99%

Children's Self‐Reports of Characteristics of Their Asthma Episodes

Burkhart

Ward

2003

Journal of Asthma

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Our purpose was to examine school-age children's self-reports of characteristics of their asthma episodes including the precipitating events, symptoms experienced during the episodes, and interventions used to resolve the episodes. Children's self-reports of their asthma episodes were assessed over a 6-week period for 42 children with persistent asthma who participated in a randomized, controlled clinical trial to evaluate the efficacy of an asthma self-management program on adherence to recommended daily peak expiratory flow rate monitoring. Children were instructed to answer the following questions on the Asthma Report Form each time they experienced an asthma episode: 1) What were you doing; 2) How did you feel; and 3) What did you do to help your breathing? Of the children, 71% experienced at least one asthma episode during the 6 weeks. There were a total of 206 episodes. Physical activity (51%) was the most cited trigger, cough alone or combined with other symptoms (84%) was the predominant symptom, and rescue asthma medication (59%) was identified most often as the intervention used by the children to resolve the asthma episode. Children's self-reports provided valuable information about their asthma episodes. The finding that most of the children experienced at least one asthma episode during the 6-week period underscores the importance of family education on how to handle asthma episodes effectively at home. Because physical activity was cited most often as a trigger for asthma episodes, families should receive education on preventive steps for averting an asthma episode prior to the child engaging in physical activity.

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Compliance with anti-tuberculosis preventive therapy among 6-year-old children

Abstract: There are no published data regarding compliance with anti-tuberculosis preventive therapy among children in Australia and limited published data worldwide. This study aimed to determine the compliance rate among 6-year-old children prescribed preventive therapy for tuberculosis infection.

Cited by 18 publications

References 7 publications

Adherence to isoniazid preventive therapy in Indonesian children: A quantitative and qualitative investigation

Adherence to isoniazid preventive therapy in Indonesian children: A quantitative and qualitative investigation

Management of children exposed toMycobacterium tuberculosis: a public health evaluation in West Java, Indonesia

Children's Self‐Reports of Characteristics of Their Asthma Episodes

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