Complexes and Chelates of Some Bivalent and Trivalent Metals with Ciprofloxacin Schiff Base

Abstract

The coordination of CIP-en (N,N'-ethylene (bis 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazine-1-yl)-quinoline-3-carboxylic acid) towards Cr(III), Mn(II), Fe(III), Co(II) and Ni(II)ions has been investigated. The elemental analysis, melting point, molar conductivity, magnetic properties, infrared, UV-Vis, mass, 1 H NMR spectra and thermal analysis studies were used to characterize the complexes. TGA and DTG have been applied to study the compositions of the compounds. The measured molar conductance values indicate that the complexes are electrolytes in nature. The biological activities of the complexes were assayed against several bacterial strains.

Spectroscopic, DFT and antimicrobial activity of Zn(II), Zr(IV), Ce(IV) and U(VI) complexes of N,N‐ chelated 4,6‐bis (4‐chlorophenyl)‐2‐amino‐1,2‐dihydropyridine‐3‐carbinitrile

“…The absence of the band at 255 nm and the shift of the reflection bands to higher values and presence of new bands in the reflection spectra of complexes indicated the formation of their metal complexes. The complexes have new bands in the range from 422 to 525 nm which may be assigned to the ligand to metal charge‐transfer …”

Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

“…The two bands observed at 1732 and 1624 cm -1 in the spectrum of the CIP-o-phdn have been assigned to the stretching vibration of carboxylic ν(COOH) and the azomethine group ν(C=N), respectively [28][29][30][31][32][33][34][35]. The absent of the band at 1732 cm -1 in all complexes and the shift of the characteristic band of azomethine group to a lower value from 1624 cm -1 to 1589 cm -1 for Cr(III), at 1574 cm -1 for Mn(II) and Fe(III), at 1570 cm -1 for Co(II) indicated that the involvement of C=N group and one oxygen of the carboxylate group in the interaction with metal ion forming six and five membered rings and the carboxylic group is deprotonated [36].…”

Spectroscopic Analyses and Antimicrobial Activity of Novel Ciprofloxacin and 7-Hydroxy-4-methylcoumarin, the Plant-Based Natural Benzopyrone Derivative

“…The IR spectrum of CIP ligand shows very strong bands at 1706 and 1620 cm −1 assignable to the stretching vibration of carboxylic ν (COOH) and the carbonyl group ν (C=O), respectively [ 31 , 32 , 40 , 41 , 42 , 47 ]. The absence of the first band in CIP and the shift of the second band of ν (C=O) to a lower value from 1620 cm −1 to an average value of 1522 cm −1 in Zr(IV) complexes reveals to the coordination of CIP through one O atom of both the carboxylato group and of the carbonyl group [ 31 , 32 , 40 , 41 , 42 , 43 , 44 ]. The asymmetric stretching vibration ( ν as ) of the ligated COO − group is found in the range 1686–1628 cm −1 and the symmetric stretching vibration ( ν s ) of all complexes appear at ≈1389 cm −1 ( Table 2 ).…”

“…To continue our investigation in the field of fluoroquinolone complexes [ 15 , 31 , 32 , 40 , 41 , 42 , 43 , 44 ], we report in the present work the synthesis and characterization of new Zr(IV) complexes formed from the interaction of ciprofloxacin hydrochloride (CIP) and a coumarin derivative, 7-hydroxy-4-methylcoumarin (HMC) ( Scheme 1 -II), with Zr(IV) in the presence of DMF, Py, and Et 3 N in ethanol as a solvent and study the effect of change of solvates on the biological activity of CIP. The isolated solid complexes were characterized using spectroscopic and thermal analysis techniques.…”