Complexation of small neutral organic molecules by water soluble calix[4]arenes

Water-Soluble Calix[4]arene Derivatives: Binding Stoichiometry and Spectroscopic Evaluation of the Host-Guest Recognition Mechanism

“…Sciotto et al have studied the interactions between alcohols, ketones, nitriles and psulfonatocalixarenes (4) and its derivatives by 1H NMR spectroscopy, 60,61 proving that the apolar aliphatic portions of the guests were included into the host hydrophobic cavity with the terminal polar groups directed towards the polar sulfonate groups of the host and to the solvent. The two most important factors for the complexation of the investigated hosts and guests are conformational properties of the receptors and electrostatic effects.…”

Supramolekulare Chemie in Wasser

“…In jüngster Zeit haben sich die Calixarene als Gerüste zur Herstellung multivalenter Amphiphile für biologische und chemische Anwendungen durchgesetzt. [103] Benzolderivate wie Benzaldehyd und Iodbenzol (K a % 8-191m…”

“…[103] Bei Benzolderivaten können sich entweder die Aryleinheit oder die Substituenten im Hohlraum befinden. [105,109,110] Wegen ihrer hohen Wasserlöslichkeit wurden Salze der sulfonierten Calix [4] [109] in Wasser derart, dass ausschließlich die Alkylammoniumgruppe in den Hohlraum aufgenommen wird.…”

Study on Complex Formation of Fluorescein-p-Sulfonatocalix[4]arene by Spectroscopic Methods

“…p-Sulfonic calix[n]arenes provided not only hydrophobic environment (benzene rings) with the above favorable properties, but also hydrophilic heads (sulfonates) and form water soluble encapsulated complexes [4]. Many researchers have studied inclusion properties of water soluble calixarenes with organic ions and neutral molecules [5]- [15]. Secondary forces are alone responsible for maintenance of the integrity of all inclusion complexes.…”