Complexation of poly(methyl methacrylate-g-propylene oxide) and alkali-metal ions

Novack, Kátia Monteiro; Oliveira, Clara Marize F.

doi:10.1007/bf00329882

Cited by 4 publications

(8 citation statements)

References 6 publications

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“…In all copolymers there was visible incorporation of fluconazole, as evidenced by the presence of crystals of the drug, besides presenting differentiated photomicrographs of the modified copolymers and emulsified copolymers.…”

Section: Resultsmentioning

confidence: 96%

“…These matrices allow the incorporation of relatively large quantities of drugs, beyond obtaining inherent advantages: versatility, effectiveness, and low cost . The System Release Drug (SRD) consists of a management system designed to extend the release of the drug in the body to sustain its plasma concentration and control the temporal and spatial localization of molecules in vivo …”

Section: Introductionmentioning

confidence: 99%

“…The equivalent graft copolymer PMMA‐g‐PEG meets characteristics of their origin polymers: PMMA resistance and transparency and appropriate structure, including good solubility in water and organic solvents, lack of toxicity, and easy processing of the PEG, with inserted between the pharmacologically active polymers and can act as drugs or may be used as carriers for other drugs …”

Section: Introductionmentioning

confidence: 99%

“…[8] The System Release Drug (SRD) consists of a management system designed to extend the release of the drug in the body to sustain its plasma concentration and control the temporal and spatial localization of molecules in vivo. [9][10][11] The equivalent graft copolymer PMMA-g-PEG meets characteristics of their origin polymers: PMMA resistance and transparency and appropriate structure, including good solubility in water and organic solvents, lack of toxicity, and easy processing of the PEG, with inserted between the pharmacologically active polymers and can act as drugs or may be used as carriers for other drugs. [10,11] In recent decades, a significant increase in the incidence of fungal diseases has been noted.…”

Section: Introductionmentioning

confidence: 99%

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Preparation, Characterization, and Biological Activity Against Artemia Salina of News Copolymer PMMA‐g‐PEG Derivatives Incorporated With Fluconazole

Silveira

Novack

Marcondes

et al. 2018

Macromolecular Symposia

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The graft copolymer PMMA‐g‐PEG meets characteristics of their origin polymers: PMMA resistance and transparency and appropriate structure, including good solubility in water and organic solvents, lack of toxicity, and easy processing of the PEG, with inserted between the pharmacologically active polymers and can act as drugs or may be used as carriers for other drugs. The PMMA‐G‐PEG copolymer and their derivatives are synthesized previously and subsequently, the copolymer derivatives passed through the process of emulsification and incorporation of the drug fluconazole. Emulsified and Incorporated derivatives copolymers are characterized by Fourier‐transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential thermal analysis (DTA), X‐ray diffraction (XRD), and scanning electron microscopy (SEM) after the incorporation, in order to evaluate their effectiveness. The efficiency of incorporation is evaluated as well as the influence of polymer chain complexity in the incorporated fluconazole. Their toxicities are determined against Artemia salina Leach. The LD50 values have also been obtained for these copolymers.

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation, Characterization, and Biological Activity Against Artemia Salina of News Copolymer PMMA‐g‐PEG Derivatives Incorporated With Fluconazole

Silveira

Novack

Marcondes

et al. 2018

Macromolecular Symposia

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“…Os reagentes fosfito de dipropila, fosfito de dibutila, fosfito de diisobutila, fosfito de diisopropila e fosfito de diisopentila foram sintetizados pelo nosso grupo de pesquisa [10][11][12] . [15,16] A obtenção do copolímero graftizado foi realizada a partir da adaptação da metodologia descrita segundo Novack e Oliveira [17] . O copolímero foi preparado em béquer a partir da dissolução de 40,00g de polietilenoglicol em 100,00 mL de diclorometano.…”

Section: Reagentes Químicosunclassified

Síntese e caracterização de novos copolímeros fosforilados

et al. 2015

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ResumoO rápido desenvolvimento da química de polímeros nos últimos anos tem acompanhado a introdução dos materiais poliméricos no campo da medicina. Polímeros com aplicações médicas podem ser subdivididos em dois grandes grupos: materiais usados em próteses e a produção de polímeros biologicamente ativos. Neste trabalho foram sintetizados copolímeros possuindo cadeia principal de poli (metacrilato de metila) e cadeias enxertadas de polietilenoglicol (COP GRAFT). A partir da síntese do copolímero enxertado inicial foram realizadas modificações em suas cadeias de modo a aumentar a possibilidade de incorporação de um fármaco que será utilizado em sistema de liberação controlada de medicamentos. Os novos compostos foram obtidos através de duas rotas sintéticas e os produtos formados ao final de cada etapa foram purificados e caracterizados. Através da técnica de infravermelho (FITIR) foi possível observar as bandas de absorções características das ligações P-H, P=O e P-O, que foram inseridas na cadeia do COP GRAFT durante a fosforilação, além das bandas de absorções características do copolímero, antes da fosforilação, como C=O e C-O. A caracterização térmica das amostras utilizando termogravimetria (TGA) e calorimetria diferencial de varredura (DSC) mostrou que apenas o copolímero de diisobutila apresentou temperatura de transição endotérmica e comportamentos de degradação compatíveis a de um polímero. Através da técnica de difração de raios X (XRD) foi possível observar uma modificação da cristalinidade das amostras, provavelmente devido a uma variação da conformação das cadeias após a inserção de novos grupos químicos. Nos cromatogramas obtidos pela técnica de cromatografia de permeação em gel (GPC) percebeu-se aumento de massa após a fosforilação com o grupo diisobutila no COPGRAFT. A reação de fosforilação foi eficiente na obtenção do copolímero de diisobutila e as técnicas aplicadas demonstraram que houve a modificação no copolímero enxertado. Palavras-chave: síntese e modificação de copolímero, fosforilação, caracterização por FTIR, DSC, TGA, XRD e GPC. AbstractThe rapid development in polymer chemistry has, in recent years, led to the introduction of polymeric materials in the field of medicine. Two major groups of polymers are used for medical applications: prosthetic and biologically active materials. We synthesized copolymers with the main chain consisting of poly (methyl methacrylate) and graft chains of poly(ethylene glycol) (COP GRAFT). Changes were made in the graft copolymer chains for a possible incorporation of a drug, such that it may be used for the controlled release of drugs. The synthesis of these new compounds is based on two synthetic routes and FTIR, differential scanning calorimetry (DSC), thermogravimetry (TGA) and X-ray diffraction (XRD) characterized the products formed at the end of each stage. Through FTIR we observed absorption bands characteristic of P-H, P=O and P-O bonds that were inserted into the polymer chain during phosphorylation of the COP GRAFT, beyond the absorption bands ...

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Chemistry Modification of PMMA‐g‐PEG copolymer

Rosa¹,

Silveira

Novack

et al. 2014

Macromolecular Symposia

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Summary Copolymers are polymers consisting of different repeat units and their production is usually motivated by the changing of polymers properties. An important application are the transportation of drugs within the organism with the aim of controlling the release of the substance. The synthesis of these new copolymers is based on simple semi‐synthesis and low cost. The synthetic routes are based on the interaction of the graft copolymer (PMMA‐g‐PEG) with a variety of reagents such as acetic anhydride, acetic acid, methyl iodide, sulfuric acid and hydrochloric acid. The products from these reactions of esterification, methylation, acetylation and halogenation will be characterized by Fourier‐transforminfrared spectroscopy (FTIR). The use of this technique allowed us to detect the main absorption bands related to the CO bonds, C‐Cl, R‐COOR and CO, thus confirming the efficiency of modification reactions of the graft copolymer chain.

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Complexation of poly(methyl methacrylate-g-propylene oxide) and alkali-metal ions

Cited by 4 publications

References 6 publications

Preparation, Characterization, and Biological Activity Against Artemia Salina of News Copolymer PMMA‐g‐PEG Derivatives Incorporated With Fluconazole

Preparation, Characterization, and Biological Activity Against Artemia Salina of News Copolymer PMMA‐g‐PEG Derivatives Incorporated With Fluconazole

Síntese e caracterização de novos copolímeros fosforilados

Chemistry Modification of PMMA‐g‐PEG copolymer

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