Complexation of curcumin using whey proteins to enhance aqueous solubility, stability and antioxidant property

Racz, Levente Zsolt; Rácz, Csaba-Pal; Horovitz, Ossi; Tomoaia, Gheorghe; Mocanu, Aurora; Kacsó, Irina; Sárközi, Melinda; Dan, Monica; Porav, Sebastian; Borodi, Gheorghe; Tomoaia-Cotişel, Maria

doi:10.24193/subbchem.2022.3.06

Cited by 5 publications

(3 citation statements)

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“…The CCM bioavailability, solubility, and stability, as well as its antioxidant activity were significantly improved by its nano complexation with whey protein concentrate [ 234 , 235 ]. In consequence, the effective role of whey protein concentrate in the cellular penetration and internalization of the CCM-WPC complex and in the specific intracellular trafficking of curcumin including mitochondria or nucleus becomes progressively important as we focus to further enhance the effectiveness of curcumin therapeutic effect.…”

Section: Curcumin Bioavailability Improvingmentioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.

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Section: Curcumin Bioavailability Improvingmentioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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“…In addition, a further functionalization of these ceramic coating with more natural substances that would not hold any side effects, such as carotenoids [104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122], would also be beneficial. Some carotenoids have been proven to exhibit antibacterial properties [123][124][125][126][127][128].…”

Section: Future Trendsmentioning

confidence: 99%

Untitled

2022

AnnalsARSciPhysChem

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Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.

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“…Curcumin is a vegetable compound widely exploited for its biological activities. Since its bioavailability, bioactivity, stability and physico-chemical behavior are less effective, strategies have been developed to improve curcumin properties by complexing with whey proteins [65][66][67][68], betacyclodextrin [69][70][71][72][73][74] with natural compounds such as piperine , silymarin, resveratrol [75,76], lipids and hydroxyapatite. Due to their unique properties, nanoparticles have found various uses in many fields starting from hydrogen production [77][78][79][80][81][82], synteses of materials with photoluminescence proprieties [83], adsorption capabilities [84,85], photocatalytic proprieties [86] to bio materials [34][35][36][37][38].…”

Section: Composite Materials Based On Hydroxyapatite 41 Hydroxyapatit...mentioning

confidence: 99%

Perspectives of Oral Dental Care

PALTINEAN¹,

FLOREA²,

Tomoaia³

et al. 2022

AnnalsARSciBio

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This research focuses on debating the negative impact on dental enamel produced by unhealthy diet, some alcoholic and non-alcoholic drinks, smoking, drug use, inadequate hygiene conditions due to poor lifestyle and physical-chemical activities. These factors denature the quality of dental enamel, and the demineralization process begins resulting in caries and periodontal diseases. Caries are the most common diseases of the oral cavity that, if not treated in time, lead to dysfunctional mastication, impaired smile, gingival inflammation, abscess, and unbearable pain. The research also addresses the remineralization of dental enamel using materials and composites based on hydroxyapatite that are capable of producing beneficial effects for strong and healthy teeth. Evaluating caries prevention methods is absolutely essential, but the most important of all is educating children from an early age that healthy teeth require proper personal hygiene.

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Complexation of curcumin using whey proteins to enhance aqueous solubility, stability and antioxidant property

Cited by 5 publications

References 0 publications

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

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Perspectives of Oral Dental Care

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