Complexation of Cd(SeCN)₂with imidazolidine-2-thione and its derivatives: Solid state, solution NMR and anti-bacterial studies

Abstract

Abstract. Reactions of imidazolidine-2-thione (Imt), 1,3-diazinane-2-thione (Diaz) and 1,3-diazipane-2-thione (Diap) with Cd(SeCN) 2 in acetonitrile resulted in the formation of 2:1 tetrahedral complexes. Both solid state and solution NMR, confirm the exocyclic thione atom to be the donor in all cases. 113 Cd shielding tensors and anisotropies were calculated from the solidstate NMR spectra. Based on the solid NMR data, a distorted tetrahedral dispositions of ligands around cadmium is proposed for the Imt complex. However, when the Imt ligand is substituted with one or two R groups (where R = Me, Et or i-Pr) forming RImt or R 2 Imt, a five coordinate complex with polymeric structure [(RImt)Cd(SeCN) 2 ]∞ or [(R 2 Imt)Cd(SeCN) 2 ]∞ is observed. Antibacterial studies of some of the complexes were carried out.

Synthesis, characterization, and antibacterial activities of copper(I) bromide complexes of thioureas: X-ray structure of [Cu(Metu)4]Br

“…In the 13 C NMR spectrum, the [C=S resonance of the ligands in the respective copper complexes is shifted upfield by about 4-13 ppm as compared to the free positions in accordance with the data observed for other complexes of d 10 metals with thiones [6,[34][35][36][37][38][39][40][45][46][47][48]. The upfield shift is attributed to the lowering of the [C=S bond order and a shift of N ?…”

Spectroscopic and Electrochemical Studies of the Interaction of Some Gold(III) Complexes with Biologically Relevant Thiones

“…At higher concentration of DIAZ (4 equiv), the C═S signal shifted further downfield to 172.32 and 171.61 ppm, respectively (Figs. A‐c and B‐c), in agreement with a previous report . The total reduction of Au(III) specie to Au(I) is confirmed by disappearance of the solution color with yellowish white precipitation.…”

“…These bands are associated with the charge transfer from metal to ligand (M → DIAZ). The band at 207 nm represents the redox reaction product [Au(DIAZ) 2 ] + .…”

1,3‐Diazepine: A privileged scaffold in medicinal chemistry

“…Metallic complexes have been investigated for their potential antimicrobial activity. For example, complexes of mercury(II), 300 zinc(II), 301 and cadmium(II), 302 with a 1,3‐diazepine‐2‐thione (Diap) ligand were described by Isab's team.…”