Complexation of aromatic drugs with single-walled carbon nanotubes

Buchelnikov, Anatoly S.; Voronin, Dmitry; Kostjukov, Victor V.; Deryabina, Tatyana A.; Khrapatiy, S. V.; Prylutskyy, Yu. І.; Ritter, Uwe; Evstigneev, Maxim P.

doi:10.1007/s11051-014-2472-5

Cited by 14 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the structural analysis performed above, as well as the literature data (e.g. 6,20,21 ), suggest the complex formation of the SWCNT and GO NPs with Dox. We assume that this effect reduces the concentration of free Dox molecules able to induce cell death, thus leading to cell protection from the antibiotic action when Dox is administered together with NPs, as compared with the Dox action as a single agent.…”

Section: Resultssupporting

confidence: 64%

“…It is known that both, GO and SWCNT, bind small aromatic molecules by formation of π-stacks with them in solution. 6,20,21 The structure of the SWCNT+Dox complex is already known 6 and was not investigated in this work. Hence, further analysis was focused on GO+Dox system.…”

Section: Resultsmentioning

confidence: 99%

“…4,5 In this regard, the conjugation of anticancer drugs, for example, doxorubicin (Dox) as a ‘gold standard’ of chemotherapy, with the representatives of carbon NPs could be promising for targeted drug delivery, overcoming of tumor cells drug resistance and reduction of side toxic effects. 6-8…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro study of the anticancer activity of various doxorubicin-containing dispersions

et al. 2018

Self Cite

View full text Add to dashboard Cite

Introduction: The aim of this research was to study the impact of various doxorubicin (Dox)-containing nanofluids, e.g. singlewalled carbon nanotube (SWCNT)+Dox, graphene oxide (GO)+Dox and DextranPNIPAM (copolymer)+Dox mixtures on HeLa cells (human transformed cervix epithelial cells, as a model for cancer cells) depending on their concentration. Methods: Structural analysis of GO+Dox complex was accomplished using Hartree-Fock level of theory in 6-31G** basis set in Gaussian. Dynamic light scattering (DLS), zeta-potential, scanning electron microscopy and confocal laser scanning microscopy were used. The cell viability was analyzed by the MTT assay. Results: The viability of HeLa cells was studied with the MTT assay after the incubation with various Dox-containing dispersions depending on their concentration. The size of the particles was determined by DLS. The morphology of the nanoparticles (NPs) was studied by scanning electron microscopy and their uptake into cells was visualized by confocal laser scanning microscopy. It was found that the Dextran-PNIPAM+Dox nanofluid in contrast to Dox alone showed higher toxicity towards HeLa cells up to 80% after 24 hours of incubation, whereas the SWCNT+Dox and GO+Dox nanofluids at the same concentrations protected cells from Dox. Conclusion: The importance of Dextran-PNIPAM copolymer as a universal platform for drug delivery was established, and the huge potential of Dextran-PNIPAM+Dox NPs as novel anticancer agents was noted. Based on the in vitro study of the SWCNT+Dox and GO+Dox nanofluids, it was concluded that SWCNT and GO NPs can be effective cytoprotectors against the highly toxic drugs.

show abstract

Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

In vitro study of the anticancer activity of various doxorubicin-containing dispersions

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Despite the fact that CNTs are used in biomedicine for cell visualization, drug delivery and bone tissue engineering, there are contradictory views on their toxicity (Kurantowicz et al 2017;Minchenko et al 2018;Prylutska et al 2008;Singla et al 2019). It has been shown that in blood stream, some types of CNTs do not cause negative effects, consequently they are potentially suitable for delivery of drugs or biologically active compounds (Buchelnikov et al 2014;Liu et al 2009;Raphey et al 2019). Low doses of CNTs doped HA nanocrystalline powders do not significantly decrease G-292 cell viability and do not induce oxidative stress after 2 days of exposure (Constanda et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Single-walled carbon nanotubes loaded hydroxyapatite–alginate beads with enhanced mechanical properties and sustained drug release ability

et al. 2020

View full text Add to dashboard Cite

Single-walled carbon nanotubes (SWCNTs) containing biomaterial with enhanced mechanical properties for the potential orthopedic application were synthesized and investigated. X-ray diffraction and X-ray fluorescence analysis were indications of the formation of calcium-deficient (Ca/P = 1.65) hydroxyapatite (HA) with a small carbonate content under influence of microwave irradiation. The investigated mechanical properties (maximal relative deformation, compressive strength and Young's modulus) of SWCNT loaded HA-alginate composites confirm their dependence on SWCNTs content. The compressive strength of HA-alginate-SWCNT and the HA-alginate control (202 and 159 MPa, respectively) lies within the values characteristic for the cortical bone. The addition of 0.5% SWCNT, in relation to the content of HA, increases the Young's modulus of the HA-alginate-SWCNT (645 MPa) compared to the SWCNT-free HA-alginate sample (563 MPa), and enhances the material shape stability in simulated physiological conditions. Structural modeling of HA-alginate-SWCNT system showed, that physical adsorption of SWCNT into HA-alginate occurs by forming triple complexes stabilized by solvophobic/van der Waals interactions and H-bonds. The high-performance liquid chromatography demonstrated the influence of SWCNTs on the sustained anaesthesinum drug (used as a model drug) release (456 h against 408 h for SWCNTfree sample). Cell culture assay confirmed biocompatibility and stimulation of osteoblast proliferation of 0.05% and 0.5% SWCNT-containing composites during a 3-day cultivation. All these facts may suggest the potential possibility of using the SWCNT-containing materials, based on HA and alginate, for bone tissue engineering.

show abstract

“…Single‐walled carbon nanotubes are supposed to be the promising pharmacological compounds of a new class with the wide spectrum of therapeutic action . At in vitro studies, it has been shown that single‐walled carbon nanotubes can be adsorbed on the membrane surface, form the transmembrane pores, block the voltage‐gated potassium channels, penetrate into cells, act as neuroprotectors and effective substrates for cultivation of neurons .…”

Section: Introductionmentioning

confidence: 99%

Single‐walled carbon nanotubes modulate cardiovascular control in rats

Shapoval

Prylutska

Kotsyuruba

et al. 2016

Materialwissenschaft Werkst

View full text Add to dashboard Cite

Effect of water dispersible single-walled carbon nanotubes on the medullary cardiovascular control was studied in normotensive (control) and spontaneously hypertensive rats using physiological and biochemical approaches. We have shown for the first time the possible contribution of nitric oxide (NO) to single-walled carbon nanotube-induced effects in the cardiovascular nuclei of the medulla oblongata (the lateral reticular nucleus and nucleus ambiguous). The data of biochemical experiments indicate that single-walled carbon nanotubes added to the medulla oblongata homogenates induce an enhancement of constitutive nitric oxide-synthase (cNOS) activity, which is mostly neuronal nitric oxide-synthase (nNOS) in the brain, and an increase in the level of nitrite (NO -2 ), a stable nitric oxide metabolite which serves nitric oxide bioavailability marker. In physiological experiments, it has been revealed that effects of single-walled carbon nanotube injection in the cardiovascular nuclei under study are attenuated after preliminary nNOS inhibiting. An analysis of single-walled carbon nanotube-induced changes in the levels of malonic dialdehyde, an oxidative stress marker, as well as the levels of reactive nitrogen species (pools of nitrate anions), and the activity of Ca 2+ -independent inducible nitric oxide synthase (iNOS) has indicated that single-walled carbon nanotubes used in the study do not promote oxidative and nitrosative stress in control and spontaneously hypertensive rats.

show abstract

Complexation of aromatic drugs with single-walled carbon nanotubes

Cited by 14 publications

References 53 publications

In vitro study of the anticancer activity of various doxorubicin-containing dispersions

In vitro study of the anticancer activity of various doxorubicin-containing dispersions

Single-walled carbon nanotubes loaded hydroxyapatite–alginate beads with enhanced mechanical properties and sustained drug release ability

Single‐walled carbon nanotubes modulate cardiovascular control in rats

Contact Info

Product

Resources

About