Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent

Толстикова, Т. Г.; Хвостов, Михаил В.; Bryzgalov, A. O.; Душкин, А. В.; Метелева, Е. С.

doi:10.2174/157018009787582688

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…On the other hand, a strong dependence of the rate constants on the concentration of GA was detected for carotenoid complexes. This fact is in accordance with earlier established changes of the structure of glycyrrhizin self-associates at the concentration range above 1 mM [46], and preclinical studies with the rat models [55][56].…”

Section: Activity Of Carotenoid-glycyrrhizin Complexessupporting

confidence: 92%

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Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Polyakov

Leshina²

2011

TOPROCJ

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Supramolecular drug delivery systems (DDS) are widely used in pharmacology during last decades for designing new preparations with improved properties. Most of fundamental and applied research in this field has been devoted to the inclusion complexes with cyclodextrins (CD), which are assumed to possess protective properties and to decrease the hydrophobic behavior of the included molecules. At present a new generation of DDS has been developing. Novel DDS are focused simultaneously on several purposes, including improved bioavailability and stability of drugs, targeted drug delivery, and enhanced activity. One of the compounds that appear to be promising is glycyrrhizic acid (or glycyrrhizin). A number of experimental facts of high therapeutic activity of glycyrrhizin conjugates have been published, but no understanding "how it works" was presented. This manuscript will highlight our attempts to answer this question using physicochemical approach, and also outline the challenges and future opportunities for medical applications of glycyrrhizin conjugates.

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Section: Activity Of Carotenoid-glycyrrhizin Complexessupporting

confidence: 92%

“…This effect might be the reason of several surprising observations of decreasing the therapeutic effect of GA complexes with some drugs with increasing GA concentration [55][56]. …”

Section: Stoichiometry and Stability Of Carotenoidglycyrrhizin Complexesmentioning

confidence: 95%

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Polyakov

Leshina²

2011

TOPROCJ

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“…Analyses of GD antiarrhythmic properties following intravenous administration to Wistar rats in the model of calcium chloride-induced arrhythmia showed that GD administered in a dose of 0.12 mg/kg before arrhythmogen injection ensured 80% animal survival, while its administration after arrhythmogen injection resulted in 90% animal survival. NF exhibited no anti arrhythmic activity at the dose of 0.12 mg/kg [14]. In the analogous experiment on ISIAH rats animal survival was 60%, which was apparently determined by higher sensitivity of these rats to calcium chloride.…”

Section: Resultsmentioning

confidence: 82%

Glycidipine, a Promising Hypotensive and Cardioprotective Agent

et al. 2011

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“…The first clathrate to be synthesized and examined was WF: GA 1:10. This component ratio had been previously selected in our other works and determined to be optimal for clathrates with GA [5,23].…”

Section: Resultsmentioning

confidence: 99%

Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

Tolstikov¹,

Хвостов²,

Лифшиц³

et al. 2011

LDDD

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The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacon's anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).

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Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent

Cited by 12 publications

References 12 publications

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Glycidipine, a Promising Hypotensive and Cardioprotective Agent

Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

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