2021
DOI: 10.1097/tp.0000000000003272
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Abstract: Background. HLA molecular mismatch (MM) is a risk factor for de novo donor-specific antibody (dnDSA) development in solid organ transplantation. HLA expression differences have also been associated with adverse outcomes in hematopoietic cell transplantation. We sought to study both MM and expression in assessing dnDSA risk. Methods. One hundred three HLA-DP-mismatched solid organ transplantation pairs were retrospectively analyzed. MM was computed using… Show more

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Cited by 7 publications
(12 citation statements)
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“…Receptor genes, cell surface, signaling, and immune genes—especially HLA genes— are all categories of genes expected to be likely candidates for balancing or positive selection because their functionality is directly tied to environmental interactions, such as response to pathogens and sense of smell or taste, and hence they are subject to evolutionary pressures. The HLA genes are known to be difficult to properly sequence because they are highly polymorphic and contain large LD blocks; however, they are of vital importance to the immune system and detailed typing of solely the HLAs is performed in settings like transplantation where matching between patient and donors is critical to avoid organ rejection (Wiebe et al 2018; Petersdorf et al 2014; Shieh et al 2020). Dramatic signatures of selection in chromosome 6, in and around the MHC which contains HLA genes, were observed, including several of the top ten LD-ABF selection peaks across all populations and around 40% of the GWAS significantly associated variants occurring in the MHC.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…Receptor genes, cell surface, signaling, and immune genes—especially HLA genes— are all categories of genes expected to be likely candidates for balancing or positive selection because their functionality is directly tied to environmental interactions, such as response to pathogens and sense of smell or taste, and hence they are subject to evolutionary pressures. The HLA genes are known to be difficult to properly sequence because they are highly polymorphic and contain large LD blocks; however, they are of vital importance to the immune system and detailed typing of solely the HLAs is performed in settings like transplantation where matching between patient and donors is critical to avoid organ rejection (Wiebe et al 2018; Petersdorf et al 2014; Shieh et al 2020). Dramatic signatures of selection in chromosome 6, in and around the MHC which contains HLA genes, were observed, including several of the top ten LD-ABF selection peaks across all populations and around 40% of the GWAS significantly associated variants occurring in the MHC.…”
Section: Resultsmentioning
confidence: 99%
“…The HLA genes are known to be difficult to properly sequence because they are highly polymorphic and contain large LD blocks; however, they are of vital importance to the immune system and detailed typing of solely the HLAs is performed in settings like transplantation where matching between patient and donors is critical to avoid organ rejection (Wiebe et al 2018;Petersdorf et al 2014;Shieh et al 2020 Analysis was run on genes containing at least 100 haplotypes for a given population.…”
Section: Genome Wide Scan For Balancing Selection Of Clinical Triosmentioning
confidence: 99%
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“…It has been reported that mismatching between a high‐expression HLA‐DPB1 alleles in the recipient and a low‐expression HLA‐DPB1 allele in the donor is associated with a high risk of graft‐versus‐host disease in recipients of hematopoietic cell transplantation (HCT), 1 and as such, HLA‐DPB1 allele compatibility is gradually being introduced for donor selection in HCT in some countries 2 . Currently, more than 1909 HLA‐DPB1 alleles have been identified around the world according to the IPD‐IMGT/HLA database release 3.47 version 3 .…”
Section: Figurementioning
confidence: 99%