Complex-forming properties of peat humic acids from a raised bog profiles

Dudare, Diana; Kļaviņš, Māris

doi:10.1016/j.gexplo.2012.12.001

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…Humic substances are heterogeneous mixtures originating from the decay or biological activities of living organisms and are composed of C, H, O, N, and S atoms, which are essential elements for the human body. Depending on their source and extraction methods, the molecular weight of humic substances may vary from several hundred to several thousand with sizes ranging from 1 nm to hundreds of nanometers . The tunable size could favor the precise regulation of pharmacokinetics, biodistribution and intratumoral bioavailability for applications in cancer therapy .…”

Section: Resultsmentioning

confidence: 99%

“…Depending on their source and extraction methods, the molecular weight of humic substances may vary from several hundred to several thousand with sizes ranging from 1 nm to hundreds of nanometers. 49 The tunable size could favor the precise regulation of pharmacokinetics, biodistribution and intratumoral bioavailability for applications in cancer therapy. 50 More importantly, the application of humic materials is quite attractive considering their extremely low cost.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Injectable and Natural Humic Acid/Agarose Hybrid Hydrogel for Localized Light-Driven Photothermal Ablation and Chemotherapy of Cancer

Hou

Yang

Zhang

et al. 2018

ACS Biomater. Sci. Eng.

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The injection of theranostic drug-laden hydrogels into subcutaneous tumors has proven to be a promising strategy to achieve precise local tumor eradication. Humic acid, a natural product of biochemical decomposition of animal and plant residues, abundantly exists in soils, peats, oceans, etc. In this study, a robust injectable thermoresponsive agarose hydrogel incorporating sodium humate (SH) and doxorubicin (DOX) was constructed as a unique agent for tumor management based on the combined chemo-photothermal therapeutic effect. SH, which strongly absorbs near-infrared (NIR) light, can efficiently convert light energy into thermal energy, induce local hyperthermia and subsequently trigger sustained drug release from the complex of the SH/DOX@hydrogel through a typical gel–sol transition, resulting in enhanced cellular uptake of therapeutic drugs. Moreover, intratumoral injection of the SH/DOX@hydrogel resulted in a simultaneous chemo-photothermal therapeutic effect against solid tumors under NIR laser irradiation, which may collectively prevent tumor recurrence. In addition, the SH/DOX@hydrogel exhibited ultralow systemic toxicity as demonstrated using an animal model. This work provides a promising attempt to develop a low-cost, light-responsive hydrogel for precise tumor therapy, which may also incorporate extra theranostic modules as an advanced platform for the treatment of cancer or other critical diseases.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Injectable and Natural Humic Acid/Agarose Hybrid Hydrogel for Localized Light-Driven Photothermal Ablation and Chemotherapy of Cancer

Hou

Yang

Zhang

et al. 2018

ACS Biomater. Sci. Eng.

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“…The humification of OM during composting is demonstrated by humic acid formation with increasing molecular weight, aromatic features, concentrations of oxygen and nitrogen and functional groups in line with the generally accepted humification process Soil OM Theories (Bernal et al, 2009). Dudare and Klavins (2013) focused on the interaction of metal ions with humic substances using different methods and comparing humic substances from different sources. But the impact of humification degree on the formation of humic-metal complexes has not received much attention until now.…”

Section: Introductionmentioning

confidence: 72%

“…In the micellar aggregates, the hydrophilic part of the molecule including carboxyl groups and phenolic hydroxyl groups apprehends the aromatic structure. Complexation with the hydrophilic part of HAs has been formed due to the interaction with metal ions, also increasing the ratio of aromatic structure (Dudare & Klavins, 2013). (Mohamed et al, 2010) Humic substances complexing capacity varies as a function of pH.…”

Section: Introductionmentioning

confidence: 99%

Characterization and metal loading capacity of humic acids derived from composted rice straw and olive pomace affected by the humification degree

Mostafa

Hegazy

El-Sedfy

et al. 2021

Sains Tanah J. Soil Sci. Agroclimatology

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Laboratory study was performed to assess the impact of humification degree of humic acids isolated from composted rice straw (RS) and olive pomace (OP) on the metal loading capacity of extracted humic acids with Fe, Mn and Zn at different pH values (4, 5 and 6). The results revealed that the highest values of total acidity, carboxyl and phenolic-OH groups were achieved by HA-c extracted from compost C. Both HA-c and FA-c realized more pronounced values of total carbon and nitrogen content. Adversely, HA-c and FA-c achieved less pronounced values of oxygen and hydrogen as well as H/C, O/C and C/N atomic ratios. The loading capacity of Fe+2 reached to optimum values at pH 5 for all studied humic acids. While the maximum loading capacity of Mn+2 or Zn+2 was achieved at pH 6. In this respect, the maximum loading capacity of Fe+2, Mn+2 and Zn+2 were obtained for HA-c followed by HA-d.

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“…Some functional groups including −COOH, −OH, and −O– are contained, which endows HS with a heterogeneous mixture. Depending on their source, extraction, and analysis method, the typical molecular mass of HS is from a few hundred to several thousands, and the size range is from 1 nm to several hundred nanometers. − …”

Section: Introductionmentioning

confidence: 99%

Treatment of Waste Gases by Humic Acid

Sun

Xie

2015

Energy Fuels

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Humic acid (HA) is a natural adsorbent and has special physical and chemical characteristics that form the foundation for disposal of pollutants from a combustor flue gas. HA, which occurs widely in soil, water, and low-rank coals, has already been proposed as a candidate that can be used as a sorbent for air pollution control. A flue gas desulfurization and denitrification (FGDD) process employing HA seems like a promising approach. It is a better choice using HA−Na as a desulfurization additive to improve wet limestone scrubbers or other FGDD processes. This paper reviews the recent development of waste gas treatment by HA with special reference to HA for removal of SO 2 , NO x , CO 2 , H 2 S, and heavy metals.

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Complex-forming properties of peat humic acids from a raised bog profiles

Cited by 11 publications

References 14 publications

Injectable and Natural Humic Acid/Agarose Hybrid Hydrogel for Localized Light-Driven Photothermal Ablation and Chemotherapy of Cancer

Injectable and Natural Humic Acid/Agarose Hybrid Hydrogel for Localized Light-Driven Photothermal Ablation and Chemotherapy of Cancer

Characterization and metal loading capacity of humic acids derived from composted rice straw and olive pomace affected by the humification degree

Treatment of Waste Gases by Humic Acid

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