Complex Copper Compounds with Pentaaminotetrazole Are the New Challenge in Treatment and Prevention of Free-Radical Conditions

Abstract

Abstract:The present article provides route of synthesis of complex copper compounds with 1.5-pentamethyltetrazole as a ligand. These compounds are considered promising antioxidants that can fi nd application in treatment and prevention of "free radical" conditions caused by a variety of reasons, e.g. harmful environmental factors. The obtained compounds were rated by their antioxidant potential; the ability to inhibit lipid peroxidation and SOD-like activity thereof were assessed by independent experimental techniques.Keywords: complex compounds with 1.5-pentamethyltetrazole as a ligand, antioxidants, lipid peroxidation, SOD-like activity IntroductionHuman body needs oxygen to enable active performance of its organs and systems. All major metabolic processes are based on oxidation-reduction reactions. In the mitochondria molecules of oxygen are not converted to water completely, up to 5% form highly reactive free radicals [1]. The products of free radical reactions are highly toxic oxygen containing radicals and peroxidates known as reactive oxygen species, hereinafter referred to as ROS [2]. These highly reactive ROS interact with a wide range of biomolecules [3][4][5][6]. To maintain desired level of free radical pool at the adverse environment is the critical issue of the day [7][8][9][10].Non-specifi c immunity comes from the mechanism of free radical formation [11, 12]. Phagocytosis causes multiple increase of free radical amount in the phagocytizing cells and 20-fold oxygen uptake boost [13].However, overactivation of free radical oxidation reactions presents typical pathological process that occurs during various medical conditions [14] and damaging infl uences. It is proved that various disease processes have free radical mechanism, e.g. shocks, atherosclerosis, brain circulation failure, peripheral circulation failure, coronary circulation failure [15], diabetes mellitis and diabetic angiopathy [16], rheumatoid, infl ammatory and degenerative diseases of locomotor system, eye lesions, pneumopathy, oncopathology, thermal injuries, various toxicoses, oncological diseases [17, 18], reperfusion injuries [19][20][21][22]. Overproduction of free radicals induced by harmful factors is the general reason of premature aging [23,24].Human body has natural protective mechanisms from free radical loads. Multi-component antioxidant defense system includes enzymes, vitamins, low molecular weight species [25][26][27].Huge loads of xenobiotics drop upon human bodies in our anthropogenic age. The body can not clear the whole amount of extra free radicals, which results in mismatch between the substances inducing free radical formation(prooxidants) and substances lowering the level of radical metabolites -antioxidants (AOs). This mistmatch leads to oxidative stress [28][29][30]. Hence, natural antioxidant defense system requires continuous supply of specifi c compounds to maintain its effectiveness [31].These substances vary over a wide range; they have different structures and derive from different origin. Their class...

Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones

“…ISSN 2306-4145 №1 (94) 2016 sulfanyl}-1,3-benzimidazoles, steroidal tetrazoles and 5-phenyl-1-(5-phenyl)-isoxazol-3-yl)-1H-tetrazoles also have demonstrated antioxidant activity [4][5][6][7][8][9]. It is very important, because processes of lipid peroxidation are of a great value for energy processes, cell division and the synthesis of actoprotectors.…”