Complex clocks

Wingate, David

doi:10.1007/bf01295814

Cited by 29 publications

(7 citation statements)

References 25 publications

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“…This can also be correlated with results obtained in other studies [21,29,32], demonstrating the important role of the ileum in the motility of the whole intestine.…”

Section: Discussionsupporting

confidence: 80%

“…In this particu lar case, the proximal segments seem to im pose their electromyographic characteristics on the more distal segments [21,29]. This does not seem to be the case in the present study since only the remaining jejunum changes its cyclic pattern after jejunal resec tion.…”

Section: Discussioncontrasting

confidence: 37%

“…It has been shown that various factors may influence the characteristics of MMC: hormonal and humoral factors [25][26][27], in trinsic nervous system [21][22][23]28], So far, studies have only shown that cyclic motor activity returns to its control pattern after intestinal transection [21,29]. In this particu lar case, the proximal segments seem to im pose their electromyographic characteristics on the more distal segments [21,29].…”

Section: Discussionmentioning

confidence: 99%

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Changes in Motility after Jejunal and Heal Resection: Electromyographic Study in Rats

Wittmann¹,

Crenner²,

Pousse³

et al. 1985

Digestion

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The aim of this work was to compare the effects of massive jejunal and ileal resections on intestinal motility using an electromyographic technique. Male Wistar rats were used: in the first group a massive jejunal resection was performed, conserving a 7-cm segment after the ligament of Treitz; the rats of the second group underwent an ileal resection, preserving 7 cm of the terminal ileum. Motility was studied at the 10th and 30th postoperative days by means of electrodes implanted throughout the remaining bowel and was expressed by the pattern of recurrence of the migrating myoelectric complex (MMC). In a fasting state, in both transected and resected animals at the 10th postoperative day, the gradient in the duration of MMC along the intestine still existed. However, on the 30th postoperative day, in animals with jejunal resection only, there was an adaptive process: the duration of MMC in the remaining jejunum was significantly increased to the duration in the ileum. After the end of the postprandial inhibition of the appearance of the MMC, on the 10th postoperative day there was a significant decrease in the duration of MMC in the ileum in both types of resection, compared to the controls. However, on the 30th postoperative day, the duration of MMC returned to its control value. In conclusion, jejunal resection seems to induce more important adaptive processes in intestinal motility than does ileal resection. The different results are discussed.

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“…This can also be correlated with results obtained in other studies [21,29,32], demonstrating the important role of the ileum in the motility of the whole intestine.…”

Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 37%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in Motility after Jejunal and Heal Resection: Electromyographic Study in Rats

Wittmann¹,

Crenner²,

Pousse³

et al. 1985

Digestion

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show abstract

“…Although the motility pattern is quite different during the fed state, it has been demonstrated that MMC organization persists [11]. In the present study, the time of injection, 40 min after the end of spontaneous P3, avoided the absolute refractory period described in the fasting state [6,12].…”

Section: Discussionmentioning

confidence: 59%

Induction of phase 3 of the migrating motor complex in human small intestine by trimebutine

Chaussade

Grandjouan

Couturier

et al. 1987

Eur J Clin Pharmacol

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The effects of trimebutine, a drug used in the treatment of various gastrointestinal motility disorders, have been investigated fed and fasted healthy subjects. Duodenojejunal motility was recorded manometrically with a 4-lumen probe. Trimebutine 50 or 100 mg was injected i.v. 3 or 25 min after observing a spontaneous Phase 3 complex in the fasted state. Other experiments were done in the postprandial state and after intravenous naloxone 0.8 mg. In the fasted state, trimebutine 100 mg, injected 25 min after a spontaneous Phase 3 complex consistently induced a premature Phase 3 complex. The mean duration of the migrating motor complex cycle decreased from 86.4 +/- 10.8 min to 32.5 +/- 1.0 min. Trimebutine 50 mg injected 3 and 25 min after a spontaneous Phase 3 complex did not significantly modify the periodicity of the migrating motor complex. Trimebutine 100 mg initiated Phase 3-like activity in the post-prandial state. Previous intravenous administration of naloxone 0.8 mg (Narcan) suppressed the stimulatory action of TMB. Thus, trimebutine is able to modify the motility pattern in the small intestine of man, possibly by acting at opioid receptors.

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“…5 When the head of the pancreas is resected, the surgical procedure interrupts the intrinsic circuitry and removes the duodenum where the pacemaker controlling the motor activity of the bowel is located. 44 This surgical procedure also disturbs circulating hormones. Tanaka et al 45 reported that resection of the canine duodenum, which is known to be the principal region for motilin secretion, impaired the cyclic increase in plasma motilin concentrations and abolished the occurrence of gastric phase III activity.…”

Section: Biliary Tract and Pancreatic Surgerymentioning

confidence: 99%

Gastrointestinal Motility After Digestive Surgery

2007

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Gastrointestinal (GI) motility dysfunction is a common complication of any abdominal surgical procedure. During fasting, the upper GI tract undergoes a cyclic change in motor activity, called the interdigestive migrating motor contraction (IMC). The IMC is divided into four phases, with phase III having the most characteristic activity. After digestive surgery, GI motility dysfunction shows a lack of a fed response, less phase II activity, more frequent phase III activity of the IMC, and some phase III activity migrating orally. Postoperative symptoms have been related to motor disturbances, such as interrupted or retrograde phase III or low postprandial activity. The causes of GI disorder are autonomic nervous dysfunction and GI hormone disruptions. The administration of a motilin agonist can induce earlier phase III contractions in the stomach after pancreatoduodenectomy. For nervous dysfunction, an inhibitory sympathetic reflux is likely to be important in postoperative motility disorders. Until recently, treatment for gut dysmotility has consisted of nasogastric suction, intravenous fluids, and observation; however, more effective treatment methods are being reported. Recent discoveries have the potential to decrease postoperative gut dysmotility remarkably after surgery.

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Complex clocks

Cited by 29 publications

References 25 publications

Changes in Motility after Jejunal and Heal Resection: Electromyographic Study in Rats

Changes in Motility after Jejunal and Heal Resection: Electromyographic Study in Rats

Induction of phase 3 of the migrating motor complex in human small intestine by trimebutine

Gastrointestinal Motility After Digestive Surgery

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