Changes in Motility after Jejunal and Heal Resection: Electromyographic Study in Rats

Wittmann, Tibor; Crenner, F.; Pousse, A.; Grenier, J F

doi:10.1159/000199227

Cited by 13 publications

(3 citation statements)

References 15 publications

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“…Intestinal motility after massive bowel resection has mainly been analyzed by absorption studies and the transit time demonstrated with radiopaque medium (6‐9). The somewhat limited studies of intestinal motility by myoelectric activity measurement (16,17) have not clarified the progressive postoperative changes of motility in conscious humans or experimental animals.…”

Section: Discussionmentioning

confidence: 99%

“…Gut absorption, and hormonal and morphologic changes after MSBR have been studied, and bowel motility has been measured by barium meals to evaluate postoperative bowel function (6‐15). However, reports of intestinal motility after MSBR using myoelectric or strain gauge transducers have been limited (16,17), and continuous recording in conscious dogs is rare (17).…”

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confidence: 99%

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Intestinal Motility after Massive Small Bowel Resection in Conscious Canines: Comparison of Acute and Chronic Phases

Uchiyama,

Iwafuchi,

Matsuda

et al. 1996

J. pediatr. gastroenterol. nutr.

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SummaryTo evaluate intestinal function after 80% massive distal small bowel resection (MSBR), we continuously monitored interdigestive and postprandial bowel motility using bipolar electrodes and/or contractile strain gauge force transducers in conscious beagle dogs before and at 2‐4 weeks (acute postoperative phase; acute phase) and 8‐13 months (chronic postoperative phase; chronic phase) after the surgery. Fasting duodenal migrating myoelectric (or motor) complexes (MMC) occurred at longer intervals in the acute phase after 80% MSBR than in control beagles. Intervals between duodenal MMC in the chronic phase were similar to those found in control beagles. MMC arising from the duodenum were often interrupted before the jejunum above the anastomosis in the acute phase, and a slight recovery of propagation frequency to the jejunum above the anastomosis was observed in the chronic phase. However, duodenal MMC did not migrate smoothly to the terminal ileum in both groups. In the acute phase, the velocity of duodenal MMC propagation was slowed in every intestinal segment, including the duodenum and the jejunum above the anastomosis, and had not recovered even long after the operation. The duration of the postprandial period without duodenal MMC was prolonged significantly in the acute phase postoperatively. Although it shortened in the chronic phase, it still remained significantly longer than in controls. These findings suggest that changes in gut motility after MSBR tend to compensate for the shorter intestine and maintain small bowel absorption early postoperatively. However, these compensatory changes decrease over the long term, and their adaptive contributions to increased intestinal absorption may decrease as well.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Intestinal Motility after Massive Small Bowel Resection in Conscious Canines: Comparison of Acute and Chronic Phases

Uchiyama,

Iwafuchi,

Matsuda

et al. 1996

J. pediatr. gastroenterol. nutr.

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“…Many investigators have confirmed the development of anatomical and functional adaptations (Grey & Morin, 1985;Hazel et al 1986;Wilson et al 1986;Kwan et al 1987) in the remaining segment. Experiments in laboratory animals have tried to enhance this response by varying the amount of bowel removed (Hanson et al 1977a), the site of resection (Antonson & Vanderhoof, 1982;Wittmann et al 1985), the postoperative time interval (Hanson et al 19773) or the diet (Biasco et al 1984;Ford et al 1985). In humans the management of these factors is limited and depends on the patient's state (Devine & Kelly, 1989).…”

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confidence: 99%

Effects of intestinal resection, cholecalciferol and ascorbic acid on iron metabolism in rats

et al. 1995

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The effect of dietary supplementation with ascorbic acid or cholecalciferol on Fe utilization was studied using the metabolic balance technique, in rats in which 50 % of the distal small intestine was removed, or in which the mid small intestine was transected and reanastomosed (controls). Three different diets were used. The first (basal diet) contained (g/kg dry wt): protein (casein + 50 mg D,L-methionine/g) 120 and fat (medium-chain triacylglycerols, olive oil and sunflower oil, in equal parts) 40. The other diets were obtained by adding ascorbic acid (150 mg/kg diet) or cholecaiciferol(O.4 mg/kg diet) to the basal diet. Apparent digestibility coefficient (ADC) and Fe retention were significantly lower in resected animals than in their respective control groups (transected rats).

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Adaptive changes in postprandial motility after intestinal resection and bypass

et al. 1988

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An electromyographic technique was used to study the changes in postprandial motility induced by jejunal and ileal resection and jejunal bypass (50% reduction of total length of small bowel). Electrodes were implanted in rats throughout the intestine. Compared to control animals, the duration of postprandial interruption of the myoelectric complex (DIMC) was rapidly increased after jejunal resection, more gradually augmented after jejunal bypass, and remained constant after ileal resection. The frequency of occurrence of spike bursts during the postprandial period was significantly decreased in the short remaining proximal segment after jejunal resection and was not changed in the ileum. The jejunal bypass induced no change in the frequency throughout the remaining bowel. Ileal resection was followed by a decrease on the jejunum. The percentage of slow waves superimposed by a spike burst remained constant after jejunal resection and bypass but was significantly decreased after ileal resection on the whole remaining intestine. These results show important modifications in postprandial motor activity of the small bowel, which appear rapidly after jejunal resection, more gradually after jejunal bypass, and which are less pronounced after ileal resection. This electromyographic study emphasizes the role of intestinal motility in the development of adaptation after small bowel resection or bypass.

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Changes in Motility after Jejunal and Heal Resection: Electromyographic Study in Rats

Cited by 13 publications

References 15 publications

Intestinal Motility after Massive Small Bowel Resection in Conscious Canines: Comparison of Acute and Chronic Phases

Intestinal Motility after Massive Small Bowel Resection in Conscious Canines: Comparison of Acute and Chronic Phases

Effects of intestinal resection, cholecalciferol and ascorbic acid on iron metabolism in rats

Adaptive changes in postprandial motility after intestinal resection and bypass

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