Complete spontaneous regression of congenital epulis in a baby by 8 months of age

Sakai, Vivien Thiemy; Oliveira, Thaís Marchini de; Silva, Thiago Cruvinel da; Moretti, Aníbal de Sant’Anna; Santos, Carlos; Machado, Maria Aparecida de Andrade Moreira

doi:10.1111/j.1365-263x.2006.00795.x

Cited by 16 publications

(8 citation statements)

References 12 publications

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“…This can be supported by the clinical observations that the lesion has no growth potential after birth, its ability to regress spontaneously (when small lesions are involved), and the lack of recurrence even after incomplete excision [4,36,37,39]. In light of these features, it has been assumed that a CGCE is either reactive in nature [12-14, 49, 50] or that it is a manifestation of a degenerative process [4,11,12,49].…”

Section: Discussionmentioning

confidence: 49%

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Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

2009

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Congenital granular cell epulis (CGCE), a rare benign lesion arising from the mucosa of the alveolar ridges of the jaws in newborns, has a clinical course characterized by lack of further growth after birth. Histomorphologically, it resembles a granular cell tumor (GCT) of the adult. The histogenesis of this lesion is unclear. We submitted a series of five CGCEs to a large panel of antibodies in order to trace the origin of the constituent granular cells. The resultant immunohistochemical profile showed positivity of these cells to vimentin, NKI/C3, and PGP9.5. This does not confirm any particular cell type for the histogenetic origin of CGCE but may rather reflect a local metabolic or reactive change, providing supporting evidence that the lesion is of a non-neoplastic nature. In addition, the granular cells were non-reactive for S-100, NGFR/p75, and inhibin-alpha, which further contributes to the distinction between a CGCE and the adult GCT.

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Section: Discussionmentioning

confidence: 49%

“…There are no reports in the literature to suggest that CGCEs increase in size after birth [2,36]. Furthermore, there is reported evidence that small lesions regressed during the first year of life [36][37][38][39]. Another point of interest is that there are no reports of recurrence of a CGCE in spite of an incomplete excision [4,36].…”

Section: Discussionmentioning

confidence: 83%

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

2009

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“…Recurrence has not been reported, even after non-radical excision, and malignant transformation did not occur. [5,11,16] Involution after birth, as in case 5, has been described in literature, but is rare [13,14].…”

Section: Discussionmentioning

confidence: 86%

“…Since female preponderance, growth of the tumour ceasing after birth and even spontaneous regression after birth have been reported, the development of the tumour might be influenced by endogenous maternal or foetal hormonal factors during pregnancy [5,9,14]. However, estrogen-and progesterone receptors have not been detected.…”

Section: Discussionmentioning

confidence: 99%

Congenital epulis of the jaw: a series of five cases and review of literature

et al. 2008

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This article describes five cases of congenital epulis, a rare and benign swelling in the mouth of a newborn, which is not widely known. We present five cases: four cases presented as single pedunculated nodules of the gingiva and in one case two nodules were present. Of all, 50% were located at the maxilla. Excision was performed in four of the five cases and in one case, spontaneous regression was awaited. No recurrence was reported. The characteristic features of congenital epulis are a pedunculated, flesh-pink coloured tumour with a predominant occurrence on the anterior maxillary alveolar ridge in a female newborn. Although the aetiology is unknown, most authors suggest a mesenchymal, rather than an odontogenic, origin. Endogenous hormonal factors might influence growth prenatally. Histological findings include granular cells with eosinophilic cytoplasm and small, eccentric nuclei. Despite the fact that the lesion can be a striking sight, spontaneous regression is possible and can be awaited. Indications for non-radical excision under local anaesthesia are severe upper airway obstruction and interference with feeding technique. In conclusion, we provide clinical and histological information about congenital epulis, so that this entity will be more easily recognised and relevant information given to parents.

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“…[13] Spontaneous regression has been reported in isolated few cases and may occur even in case of incomplete resection. [14] Immunohistochemically, CGCT shows a negative staining for S-100, CD31, CD68, chromogranin, desmin, keratins, and smooth muscle actin. Moreover, a positive staining result is seen for vimentin and neuron-specific enolase.…”

Section: Discussionmentioning

confidence: 99%

Multiple Congenital Granular Cell Tumor in a Neonate - A Rare Case

et al. 2018

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Congenital granular cell tumor (CGCT) is an uncommon congenital benign epulis in neonates. A preliminary diagnosis is usually put forth clinically but may be confused with other anomalies. Herein, we report an unusual case of intra-oral congenital granular cell tumor in a 4-day-old female newborn. The tumor was excised completely. At 3-month follow-up, the baby is doing fine without any recurrence.

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Complete spontaneous regression of congenital epulis in a baby by 8 months of age

Abstract: After 8 months, the lesion had completely regressed, meaning that the girl did not have to be exposed to unnecessary surgical procedures in her first few days of life. The eruption of the upper anterior teeth was not affected.

Cited by 16 publications

References 12 publications

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

Congenital epulis of the jaw: a series of five cases and review of literature

Multiple Congenital Granular Cell Tumor in a Neonate - A Rare Case

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