Complete remission of cerebral endometriosis with dienogest: a case report

Maniglio, Paolo; Ricciardi, Enzo; Meli, Federica; Tomao, Federica; Peiretti, Michele; Caserta, Donatella

doi:10.1080/09513590.2018.1463362

Cited by 12 publications

(15 citation statements)

References 23 publications

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“…18,19 Two histologically confirmed cases of cerebral endometriosis have been reported: one in 1987 by Thibodeau et al 19 and one in 1993 by Ichida et al 17 There is a third case of catamenial epilepsy with presumed cerebral endometriosis. 20 A fourth case was published in 2018 by Maniglio et al 21 The correct treatment for cerebral endometriosis is unknown. The only published case of cerebellar endometriosis is from 2004.…”

Section: Discussionmentioning

confidence: 99%

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Case Report of Cerebellar Endometriosis

Meggyesy

Friese

Gottschalk

et al. 2020

J Neurol Surg A Cent Eur Neurosurg

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Endometriosis is a disorder in women which is characterized by extrauterine manifestations. We describe a case of cerebellar endometriosis in a 39-year-old woman who underwent posterior fossa decompression multiple times without establishing a correct diagnosis. Her neurologic status progressively worsened due to chronic hydrocephalus and brainstem compression by cysts. Late in the clinical course, histology from the cyst wall was taken that revealed endometriosis with clear cells and positive immunohistology for progesterone and estrogen receptors. Treatment with gestagens was started but did not improve the patient's status. In patients with chronic recurring intracranial cysts and hydrocephalus, cerebral endometriosis should be considered.

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Section: Discussionmentioning

confidence: 99%

“…26 A case report published by Maniglio et al in 2018 showed remission of cerebral endometriosis after Dienogest treatment. 21 Dienogest is currently the only drug showing documented improvement of central nervous system endometriosis without surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

Case Report of Cerebellar Endometriosis

Meggyesy

Friese

Gottschalk

et al. 2020

J Neurol Surg A Cent Eur Neurosurg

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“…So, we believe COCs could be the first choice for long term use in these patients. Recently, there were reports of Dienogest in the TES patient recurrent after surgery [4] and the patient with cerebral endometriosis [15].…”

Section: Discussionmentioning

confidence: 99%

“…The most common anatomical location of endometriosis is pelvic cavity, and it is rarely found in extra pelvic cavity [13]. The extragenital endometriosis represents 5-12% of endometriosis [1,2] and has been reported in multiple organ and systems, such as urinary tract [14], brain [15], gastrointestinal tract [16] and lungs. Though the prevalence of endometriosis is around 15% [17], the extragenital endometriosis represents 5% of the localizations [1], and the TES is very rare [13], and it is even rarer to have TES with catamental hemoptysis as the main clinical manifestation, so the prevalence and etiology of thoracic endometriosis is unknown as most data comes from simple case reports or short series [13].…”

Section: Introductionmentioning

confidence: 99%

Thoracic Endometriosis presented as catamental hemoptysis: Fourteen Cases of a Rare Disease and the hormonal treatment management

Dai

Liu

et al. 2020

Preprint

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Background: Thoracic endometriosis syndrome (TES) is a rare disease in which a functioning endometrial tissue is observed in the pleura, lung parenchyma, airways, or diaphragm. The optimal management of this disease remains a matter of debate Methods: Retrospective study in one university based tertiary care hospital between 1997 to 2017. 14 women presented as CH diagnosed with thoracic endometriosis were included. The main outcome of measure was cessation or recurrence of the clinical manifestations of thoracic endometriosis. Baseline parameters were presented using descriptive statistics. For categorical variables, Pearson’s chi-square tests or Fisher’s exact tests was used as appropriate to describe the characteristic of thoracic endometriosis presented as CH, and the long-term prognosis after hormonal treatment. Results : The mean onset age of the 14 patients was 30.21±5.40 years. Catamenial hemoptysis (CH) was characteristic symptom of these patients, and most of patients (13/14, 92.9%) had regular menstruation and only 42.9% (6/14) of the patients complained of different degrees of dysmenorrhea. All patients underwent chest computed tomography (CT) scan during menstruation and 2 or 3 weeks after menstruation, which showed the obvious shrinking or disappearance of the lesions. No active bleeding on bronchial mucosa were observed in patients with CH, and the bronchoalveolar lavage (BAL) did not find the typical abnormality. All of patients were given GnRH-a for 3 to 6 months, eleven of them were administered with COCs cyclically after GnRH-a. All patients were followed up and the median follow-up duration was 24 months. Hemoptysis recurrence was observed in one patient. Conclusion: CH is a rare clinical entity of thoracic endometriosis, which has the typical cyclic manifestation with menstruation. The change of CT images during and after menstruation or the response to GnRHa were helpful for accurate diagnosis. Hormonal treatment with GnRH-a followed by COCs cyclically could be employed as a choice of therapy for efficient management of thoracic endometriosis.

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“…However, data research of medical literature supporting this diagnosis shows a small number of studies and the specific research on medline led to the finding of only four case reports. 1–4…”

Section: Introductionmentioning

confidence: 99%

A surgical solution for a catamenial epilepsy medical therapy-resistant: A presumed case of cerebral endometriosis?

Maiorana

Alio

Giorgia

et al. 2020

Journal of Endometriosis and Pelvic Pain Disorders

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The presence of catamenial epilepsy in patients diagnosed with endometriosis is the symptom that would direct towards a suspected cerebral endometriotic localization. However, data research of medical literature supporting this diagnosis shows a small number of studies and the specific research on medline led to the finding of only four case reports. Hence forward, we will report a case of a patient with the surgical diagnosis of ovarian endometriosis, whom had signs of catamenial epilepsy resistant to medical therapy, and with contraindication to hormone therapy because of cerebral ischemic episodes, subjected to laparoscopic bilateral ovarosalpingectomy.

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Complete remission of cerebral endometriosis with dienogest: a case report

Cited by 12 publications

References 23 publications

Case Report of Cerebellar Endometriosis

Case Report of Cerebellar Endometriosis

Thoracic Endometriosis presented as catamental hemoptysis: Fourteen Cases of a Rare Disease and the hormonal treatment management

A surgical solution for a catamenial epilepsy medical therapy-resistant: A presumed case of cerebral endometriosis?

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