Case Report of Cerebellar Endometriosis

Meggyesy, Michael; Friese, Michael; Gottschalk, Jack A.; Kehler, Uwe

doi:10.1055/s-0040-1701622

Cited by 8 publications

(10 citation statements)

References 23 publications

(22 reference statements)

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“…All the cases collected, including our case, concerned women who showed an onset of neurological or psychiatric symptoms during the childbearing age (20–44 years). All cases found in the literature review were described by specialists in the neurological or gynecological field, including four clinical cases described by neurologists [ 40 , 41 , 42 , 45 ], two provided by gynecologists [ 44 , 46 ], and one by a gynecologist together with a neurologist [ 43 ]. While neurological symptoms dominated the clinical picture in most cases, psychiatric disorders were never reported.…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral endometriosis has been identified with certainty in four woman via the histological analysis of the lesions after surgical removal [ 40 , 41 , 42 , 45 ]. In two of these cases, brain MRI findings that were suggestive of cerebral endometriosis had been previously discovered.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Meggyesy et al described the case of a 39-year-old woman that had undergone multiple operations due to infratentorial brain cysts with consecutive chronic hydrocephalus [ 45 ]. She had never experienced neurologic symptoms during her menses.…”

Section: Literature Reviewmentioning

confidence: 99%

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Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review

Elefante

Brancati

Oragvelidze

et al. 2022

JCM

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Endometriosis is a systemic medical condition characterized by endometrial tissue that is abnormally implanted in extrauterine sites, including the central nervous system. In this article, we reported the case of a patient with presumed cerebral endometriosis who was diagnosed with bipolar disorder and panic disorder and systematically reviewed the literature for previously reported neuropsychiatric symptoms in patients with cerebral and cerebellar endometriosis. The PubMed, Scopus, and Web of Science bibliographic databases were searched according to the PRISMA guidelines. Seven previous case reports were found and described. While neurological disturbances dominated the clinical picture in the cases retrieved from the literature, our patient represented the first case to show both neurological and psychiatric manifestations. Atypical features of bipolar disorder including chronic mood instability, mixed episodes, and excitatory interepisodic symptoms were highlighted. During the neuropsychological evaluation, a dysexecutive profile consistent with frontal lobe pathology was evidenced. We hypothesized that the course and features of the illness were largely influenced by the presence of documented brain lesions compatible with endometrial implants, especially in the frontal region. Accordingly, patients with endometriosis who exhibit neurological as well as mental symptoms should be investigated for cerebral lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review

Elefante

Brancati

Oragvelidze

et al. 2022

JCM

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“…EMS can be traditionally divided into three types, i.e., peritoneal, ovarian EMS and deep invasive EMS. Rare EMS cases of distal organs, such as thoracic EMS and cerebellar EMS, have been reported in case reports (Meggyesy et al, 2020;Chen and Li, 2021). However, the pathophysiology of EMS is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives

Li¹,

Wang²,

Ding³

et al. 2022

Front. Pharmacol.

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The gut microbiota (GM) has received extensive attention in recent years, and its key role in the establishment and maintenance of health and in the development of diseases has been confirmed. A strong correlation between the GM and the progression of endometriosis (EMS) has been observed in emerging research. Alterations in the composition and function of the GM have been described in many studies on EMS. In contrast, the GM in the environment of EMS, especially the GM metabolites, such as bile acids and short-chain fatty acids that are related to the pathogenesis of EMS, can promote disease progression. Chenodeoxycholic acid (CDCA), as one of the primary bile acids produced in the liver, is metabolized by various enzymes derived from the GM and is critically important in maintaining intestinal homeostasis and regulating lipid and carbohydrate metabolism and innate immunity. Given that the complexity of CDCA as a signalling molecule and the interaction between the GM and EMS have not been clarified, the role of the CDCA and GM in EMS should be understood from a novel perspective. However, few articles on the relationship between CDCA and EMS have been reviewed. Therefore, we review the available and possible potential links between CDCA, the GM and EMS and put forward the hypothesis that CDCA and its derivative obeticholic acid can improve the symptoms of EMS through the GM.

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“…The estimated prevalence of endometriosis in the female population is about 1-10% depending on sampling and diagnostic methods [2,3]. Extragenital endometriosis usually occurs in the pelvic organs, but like cancer, it can spread seeding into the brain [4], lungs [5], or other sites. Circulating endometrial cells capable of disseminating were found in about 80% of patients with endometriosis [6].…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stromal Cells Isolated from Ectopic but Not Eutopic Endometrium Display Pronounced Immunomodulatory Activity In Vitro

et al. 2021

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A comparative analysis of the cell surface markers and immunological properties of cell cultures originating from normal endometrium and endometrioid heterotopias of women with extragenital endometriosis was carried out. Both types of cell cultures expressed surface molecules typical of mesenchymal stromal cells and did not express hematopoietic and epithelial markers. Despite similar phenotype, the mesenchymal stromal cells derived from the two sources had different immunomodulation capacities: the cells of endometrioid heterotopias but not eutopic endometrium could suppress dendritic cell differentiation from monocytes as well as lymphocyte proliferation in allogeneic co-cultures. A comparative multiplex analysis of the secretomes revealed a significant increase in the secretion of pro-inflammatory mediators, including IL6, IFN-γ, and several chemokines associated with inflammation by the stromal cells of ectopic lesions. The results demonstrate that the stromal cells of endometrioid heterotopias display enhanced pro-inflammatory and immunosuppressive activities, which most likely impact the pathogenesis and progression of the disease.

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Case Report of Cerebellar Endometriosis

Cited by 8 publications

References 23 publications

Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review

Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review

Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives

Mesenchymal Stromal Cells Isolated from Ectopic but Not Eutopic Endometrium Display Pronounced Immunomodulatory Activity In Vitro

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