Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under Viscum album Extracts After Resistance to R-CHOP: A Case Report

Gutsch, J.; Werthmann, Paul G.; Rosenwald, Andreas; Kienle, Gunver S.

doi:10.21873/anticanres.12865

Cited by 12 publications

(5 citation statements)

References 32 publications

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“…album has been the subject of numerous studies exploring its antitumour effects in various forms of extract. Aqueous extracts of V. album have been shown to have cytotoxic effects on a variety of cell lines, including lymphoma and squamous carcinoma of the tongue [27,28]. Furthermore, the alcoholic extract from V. album showed antiproliferative effects in HeLa cells, without showing cytotoxic effects in healthy fibroblasts [29].…”

Section: Resultsmentioning

confidence: 99%

Polyphenols Content and in Vitro Antitumour Activity of Hydroalcoholic Extract of Viscum Album in Two Pigmented and Unpigmented Skin Cancer Cell Lines

SALAVAT¹

2022

FARMACIA

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Malignant melanoma is the most aggressive type of skin cancer, with an increasing annual incidence. In addition to cutaneous melanoma, another form of melanoma with an increased death rate is uveal melanoma. With both types of melanomas, there is a risk that the malignant cells will become resistant to conventional antitumour therapy. Thus, the present study aimed to evaluate the antitumour effect of a hydroalcoholic extract of Viscum album (VAex) on a pigmented cell line (B164A15) as well as unpigmented (A431). The cytotoxic effect was also followed in the case of a healthy human keratinocyte cell line. The results showed that at low concentrations (< 500 μg/mL), VAex has a selective cytotoxic effect, with healthy cells not being affected. In addition, in the case of tumour cells, VAex exerted a concentration-dependent cytotoxic effect, causing morphological and structural changes in the nucleus, with an apoptotic-like effect. The most affected cells were the unpigmented ones (A431), requiring additional studies to elucidate the mechanism of antitumour action, but also to determine the influence of melanin on the biological action of VAex. RezumatMelanomul malign este cel mai agresiv tip de cancer de piele, cu o incidență anuală în creștere. Pe lângă melanomul cutanat, o altă formă de melanom cu o rată crescută a mortalității este melanomul uveal. În cazul ambelor tipuri de melanoame, există riscul ca celulele maligne să devină rezistente la terapia antitumorală convențională. Astfel, studiul de față a avut ca scop evaluarea efectului antitumoral al unui extract hidroalcoolic de Viscum album (VAex) asupra unei linii celulare pigmentate (B164A15), precum și asupra unei linii celulare nepigmentate (A431). Efectul citotoxic a fost urmărit, de asemenea, în cazul unei linii celulare de keratinocite umane sănătoase. Rezultatele au arătat că, la concentrații mici (< 500 μg/mL), VAex are un efect citotoxic selectiv, celulele sănătoase nefiind afectate. În plus, în cazul celulelor tumorale, VAex a exercitat un efect citotoxic dependent de concentrație, provocând modificări morfologice și structurale în nucleu, cu un efect de tip apoptotic. Cele mai afectate au fost celulele nepigmentate (A431), fiind necesare studii suplimentare pentru elucidarea mecanismului de acțiune antitumorală, dar și pentru a determina influența melaninei asupra acțiunii biologice a VAex.

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Section: Resultsmentioning

confidence: 99%

Polyphenols Content and in Vitro Antitumour Activity of Hydroalcoholic Extract of Viscum Album in Two Pigmented and Unpigmented Skin Cancer Cell Lines

SALAVAT¹

2022

FARMACIA

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“…Gastrointestinal lymphoma is the most common lymphatic neoplasm in cats, and the reported incidence is higher than in any other species [127]. Only a small number of case reports on VAE treatment in human lymphoma patients is available, reporting tumor reduction and even complete remission with VAE treatment [128][129][130][131].…”

Section: Leukemiamentioning

confidence: 99%

Viscum album L., a Therapeutic Option for Neoplastic Diseases in Companion Animals? A Systematic Review

Biegel¹,

Mevissen²,

Schüller³

et al. 2022

Complement Med Res

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Cancer is a common disease in humans and in companion animals and treatment is challenging. The aim of this systematic review was to identify and assess the potential use of Viscum album L. extracts (VAE) for treatment of neoplastic diseases in companion animals. Peer-reviewed animal, in vivo and in vitro studies were included, considering the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and a measurement tool to assess systematic reviews (AMSTAR). Overall, 6,148 references were identified. Following a predefined protocol, 114 full-text references were assessed. Ultimately, 61 references were included for further assessment, 25 references included in vitro experiments, 26 included in vivo and clinical experiments and 10 references included both in vitro and in vivo experiments. These 61 references comprised data of 193 in vitro and 67 in vivo and clinical experiments. Most of the 67 in vivo and clinical experiments were conducted with mice (59), followed by rats (4), dogs (3) and horses (1). So far, oral melanomas, mammary tumors and sticker sarcomas in dogs, as well as sarcoids in horses, have been investigated in controlled clinical trials. A scoring system was established to evaluate the outcomes of each study based on defined effect levels. The efficacy of VAE treatment was most pronounced for melanomas, sarcomas, mammary carcinoma and equine sarcoids. The limited number and quality of published studies on VAE treatment in companion animals impedes to draw definitive conclusions regarding the efficacy of VAE in the treatment of cancer. Thus, further research is needed to elucidate the impact of VAE on the treatment of cancer in companion animals and possible underlying mechanisms.

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“…Unfortunately, about 50% of such patients will relapse, and the 3-year overall survival rate after recurrence is about 30% [3]. Recurrent patients have serious side effects due to the use of high-dose chemotherapy drugs, and recurrent lymphoma is insensitive to follow-up treatment using the initial chemotherapy regimen and displays cross-resistance for a variety of anticancer drugs [4]. Therefore, identifying novel anticancer drugs with high efficiency and low toxicity in the treatment of NHL is a vital topic in research.…”

Section: Introductionmentioning

confidence: 99%

Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

Zhao

Sun²,

et al. 2020

Preprint

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Background Non-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibod y targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Results Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, pH response, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.Conclusions Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

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Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under Viscum album Extracts After Resistance to R-CHOP: A Case Report

Abstract: As complete remission of lymphoproliferative disorders after VAE treatment has been previously reported, further investigations of VAE in lymphoma seem highly worthwhile.

Cited by 12 publications

References 32 publications

Polyphenols Content and in Vitro Antitumour Activity of Hydroalcoholic Extract of Viscum Album in Two Pigmented and Unpigmented Skin Cancer Cell Lines

Polyphenols Content and in Vitro Antitumour Activity of Hydroalcoholic Extract of Viscum Album in Two Pigmented and Unpigmented Skin Cancer Cell Lines

<b><i>Viscum album</i></b> L., a Therapeutic Option for Neoplastic Diseases in Companion Animals? A Systematic Review

Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

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